Paediatric multiple sclerosis: examining utility of the McDonald 2010 criteria
Abstract
The new McDonald 2010 criteria have been recommended in paediatric multiple sclerosis (PMS). We aimed to assess the utility of McDonald 2010 criteria in comparison with 2007 International Paediatric Multiple Sclerosis Study Group (IPMSSG)-recommended criteria for PMS diagnosis. Retrospective analysis of 38 PMS cases from three UK demyelination clinics was conducted. Dissemination in space (DIS) and time (DIT) for both McDonald and IPMSSG criteria were noted on initial and follow-up magnetic resonance imaging (MRI). At first MRI scan, IPMSSG DIS criteria were fulfilled in 68% of scans and McDonald DIS criteria in 84%. In total, 11/18 children given gadolinium contrast fulfilled both McDonald DIS and DIT criteria on initial scan. The 2010 McDonald criteria appear more sensitive than IPMSSG and may allow PMS diagnosis at first presentation of CIS in at least a half of cases.
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Several studies support the applicability of the 2010 McDonald Criteria in children.
“Several studies support the applicability of the 2010 McDonald Criteria in children. 29-36”
From Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria (2018) · cites this paper as [36]
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- Authors
- Sedani, S., Lim, M., Hemingway, C., Wassmer, E., & Absoud, M.
- Affiliations
- Birmingham Children's Hospital (GB)
- Department of Paediatric Neurology, Evelina Children’s Hospital, Guy’s and St Thomas’ NHS Trust, London, UK
- Great Ormond Street Hospital (GB)
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2011-10-19
- Volume
- 18
- Issue
- 5
- Pages
- 679-682
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W2036805502
- Cited by
- 28
- References
- 9
- Citations by year
- 2024: 2 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 7 · 2012: 3
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Multiple Sclerosis Journal (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Action Medical Research
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Family Practice › Clinical Reasoning and Diagnostic Skills
- Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
- Keywords
- pediatric multiple sclerosis, diagnostic criteria, dissemination in space, dissemination in time, gadolinium-enhancing lesions, clinically isolated syndrome, demyelination, magnetic resonance imaging
- MeSH terms
- Adolescent, Age Factors, Brain, Child, Contrast Media, England, Female, Humans, Magnetic Resonance Imaging, Male, Multiple Sclerosis, Predictive Value of Tests, Prognosis, Retrospective Studies, Sensitivity and Specificity, Severity of Illness Index, Time Factors
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