Neurofilament levels are associated with blood–brain barrier integrity, lymphocyte extravasation, and risk factors following the first demyelinating event in multiple sclerosis

Uher, Tomas; McComb, Mason; Galkin, Shery; Srpova, Barbora; Oechtering, Johanna; Barro, Christian; Tyblova, Michaela; Bergsland, Niels; Krasensky, Jan; Dwyer, Michael; Havrdova, Eva Kubala; Posova, Helena; Vaneckova, Manuela; Zivadinov, Robert; Horakova, Dana; Kuhle, Jens; Ramanathan, Murali

doi:10.1177/1352458520912379

Neurofilament levels are associated with blood–brain barrier integrity, lymphocyte extravasation, and risk factors following the first demyelinating event in multiple sclerosis

Background: Increased blood brain barrier (BBB) permeability, CNS inflammation and neuroaxonal damage are pathological hallmarks in early multiple sclerosis (MS). Objective: To investigate the associations of neurofilament light chain (NfL) levels with measures of BBB integrity and central nervou…