The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Multiple sclerosis in childhood: clinical features of 149 cases
Abstract
From the retrospective study of 3375 patients affected by clinically definite or probable multiple sclerosis (MS), 149 patients were collected with onset of the disease before the age of 16 years (4.4%). Female/male ratio was higher than that of the adult onset MS (AOMS) population (2.2 vs 1.6) particularly at ages of onset after 12 years (3.0, P=0.007 vs AOMS). Among initial symptoms, those suggesting brainstem dysfunction (25%) were more frequent compared to other systems and compared to AOMs symptoms; motor and sensory disturbances were slightly less frequent (respectively 17.5% and 18.3%). Optic neuritis appeared in 16.5% of cases with onset in childhood and in 16.2% of cases with AOMS, cerebellar disturbances respectively in 9.1 % and 7.7%. The first interattack interval and the clinical course of early onset MS did not differ significantly from AOMS. In early onset MS patients with disease duration < 8 years, cases with EDSS > 6 were slightly more frequent than in the AOMS group (P=0.04). The frequency of cases for different levels of disability was similar for disease duration > 8 years.
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Citations
Cites
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011
Cited by
Gender differences in autoimmune disease
Ngo, S. T., Steyn, F. J., & McCombe, P. A. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.04.004 · Cited by 1,074
Early onset multiple sclerosis: A longitudinal study
Boiko, A., Vorobeychik, G., Paty, D., Devonshire, V., Sadovnick, D., & Neurologists*, T. U. M. C. (2002) · Neurology · doi:10.1212/wnl.59.7.1006 · Cited by 417
Banwell, B., Krupp, L., Kennedy, J., Tellier, R., Tenembaum, S., Ness, J., Belman, A., Boiko, A., Bykova, O., Waubant, E., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70196-5 · Cited by 344
An overall view of the most common experimental models for multiple sclerosis
Dedoni, S., Scherma, M., Camoglio, C., Siddi, C., Dazzi, L., Puliga, R., Frau, J., Cocco, E., & Fadda, P. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106230 · Cited by 79
Interferon-β1bin multiple sclerosis
Buttmann, M., & Rieckmann, P. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.3.227 · Cited by 43
Metadata
- Authors
- Ghezzi, A., Deplano, V., Faroni, J., Grasso, M., Liguori, M., Marrosu, G., Pozzilli, C., Simone, I., & Zaffaroni, M.
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 1997-02
- Volume
- 3
- Issue
- 1
- Pages
- 43-46
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W2021506523
- Cited by
- 309
- References
- 1
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Multiple sclerosis in childhood: clinical features of 149 cases. https://app.cochat.ai/papers/10.1177/135245859700300105
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- Ghezzi, A., Deplano, V., Faroni, J., Grasso, M., Liguori, M., Marrosu, G., Pozzilli, C., Simone, I., & Zaffaroni, M. (1997). Multiple sclerosis in childhood: clinical features of 149 cases. Multiple Sclerosis Journal. https://doi.org/10.1177/135245859700300105
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
