The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Oligodendrocyte and axon pathology in clinically silent multiple sclerosis lesions
Abstract
Oligodendrocyte and axon pathology was studied in 11 autopsy cases of clinically silent multiple sclerosis. A total of 54 lesions, either demyelinated or late remyelinated, were distributed through the whole brain and spinal cord with 39% of the lesions located in periventricular areas. Determination of axon density revealed an average reduction of 64% and 59% in demyelinated and remyelinated lesions with an extreme variation between different plaques and cases. Oligodendrocytes were identified by immunocytochemistry for myelin oligodendrocyte glycoprotein (MOG) and in situ hybridization for proteolipid protein (PLP) mRNA. Oligodendrocytes were almost completely lost in demyelinated lesions; remyelinated lesions revealed preservation of a considerable number of oligodendrocytes within the lesions. At the border between plaques and the periplaque white matter, similar oligodendrocyte numbers as in remyelinated lesions were found. Different factors including lesion site, axonal preservation and remyelination may thus contribute to the clinical nonappearance of multiple sclerosis lesions.
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Cites
Multiple sclerosis: Remyelination of nascent lesions: Remyelination of nascent lesions
Prineas, J. W., Barnard, R. O., Kwon, E. E., Sharer, L. R., & Cho, E. ‐. (1993) · Annals of Neurology · doi:10.1002/ana.410330203 · Cited by 574
Cited by
Linker, R. A., Lee, D.-H., Ryan, S., van Dam, A. M., Conrad, R., Bista, P., Zeng, W., Hronowsky, X., Buko, A., Chollate, S., et al. (2011) · Brain · doi:10.1093/brain/awq386 · Cited by 1,155
Self-citationAn updated histological classification system for multiple sclerosis lesions
Kuhlmann, T., Ludwin, S., Prat, A., Antel, J., Brück, W., & Lassmann, H. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1653-y · Cited by 692
Self-citationIron and neurodegeneration in the multiple sclerosis brain
Hametner, S., Wimmer, I., Haider, L., Pfeifenbring, S., Brück, W., & Lassmann, H. (2013) · Annals of Neurology · doi:10.1002/ana.23974 · Cited by 519
Self-citationA quantitative analysis of oligodendrocytes in multiple sclerosis lesions
Lucchinetti, C., Brück, W., Parisi, J., Scheithauer, B., Rodriguez, M., & Lassmann, H. (1999) · Brain · doi:10.1093/brain/122.12.2279 · Cited by 464
Self-citationProgressive multiple sclerosis: from pathophysiology to therapeutic strategies
Faissner, S., Plemel, J. R., Gold, R., & Yong, V. W. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0035-2 · Cited by 459
Metadata
- Authors
- Mews, I., Bergmann, M., Bunkowski, S., Gullotta, F., & Brück, W.
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 1998-04
- Volume
- 4
- Issue
- 2
- Pages
- 55-62
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W2158424311
- Cited by
- 160
- References
- 1
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Oligodendrocyte and axon pathology in clinically silent multiple sclerosis lesions. https://app.cochat.ai/papers/10.1177/135245859800400203
- The paper
- Mews, I., Bergmann, M., Bunkowski, S., Gullotta, F., & Brück, W. (1998). Oligodendrocyte and axon pathology in clinically silent multiple sclerosis lesions. Multiple Sclerosis Journal. https://doi.org/10.1177/135245859800400203
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
