The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Hypoxia and the Tumor Microenvironment
Open accessAbstract
Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis. In this review, these effects of hypoxia on tumor biology will be discussed, along with their significance for tumor detection and treatment.
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Cites
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Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
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“Like increased angiogenesis, these changes are mediated by hypoxia-inducible factor 1a (HIF-1a) driven transcription, which leads to upregulation of both glucose transporters and genes involved in glycolysis.(44) Li et al have observed a strong association between hypoxia, glucose Figure 3.”
BackgroundNormalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
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Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
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Fundamentals of Cancer Metabolism
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Exploiting tumour hypoxia in cancer treatment
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Cited by
Tumor hypoxia: From basic knowledge to therapeutic implications
Liao, C., Liu, X., Zhang, C., & Zhang, Q. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.12.011 · Cited by 223
Shah, S., & D’Souza, G. G. M. (2025) · Cells · doi:10.3390/cells14100732 · Cited by 83
“This spatial limitation is primarily attributed to architectural and vascular irregularities that create steep gradients in oxygen, nutrient availability, and pH [102].”
Xu, M., Fei, J., Xiao, Z.-X., & Yi, Y. (2026) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025106 · Cited by 2
Metadata
- Authors
- Li, Y., Zhao, L., & Li, X.-F.
- Venue
- Technology in Cancer Research & Treatment
- Publisher
- SAGE Publications
- Published
- 2021-01-01
- Volume
- 20
- Pages
- 15330338211036304-15330338211036304
- ISSN
- 1533-0338 (ISSN-L)
- 1533-0346
- OpenAlex
- W3187751359
- Cited by
- 394
- References
- 86
- FWCI
- 18.23
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
