Discriminative Analysis of Mild Alzheimer’s Disease and Normal Aging Using Volume of Hippocampal Subfields and Hippocampal Mean Diffusivity: An In Vivo Magnetic Resonance Imaging Study
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Background: Studies discovered that the hippocampal subfields are differentially affected by pathological damage, and magnetic resonance (MR) diffusion tensor imaging parameters might be more sensitive measures of early degeneration in Alzheimer’s disease (AD) than conventional MR imaging techniques. The purpose of this study was to evaluate the significance of the volume of hippocampal subfields and the mean diffusivity (MD) value of hippocampus in discrimination between mild AD and normal aging. Methods: A total of 29 patients with mild AD and 30 normal aging were scanned. Binary logistic regression analysis was applied to assess the diagnostic significance of the volumes of hippocampal subfields and the MD value of hippocampus. Results: All hippocampal subfields except right tail atrophied significantly in the mild AD group ( P < .05). The relative volumes of right CA1 and subiculum subfields entered the binary logistic regression model. The accuracy was 91.8%, which was improved to 93.9% as the MD value of right hippocampus entered the model. Conclusion: Atrophy was present in almost all hippocampal subfields at mild AD stage. The volumes of CA1 and subiculum were of the most diagnostic significance in discrimination of mild AD, which can be improved by the combination of volume and diffusivity analysis.
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The subiculum is one of the earliest affected regions in AD or prodromal AD patients.
“pathological studies have also indicated that the subiculum is one of the earliest affected regions in AD or prodromal AD patients [4, 15, 44, 73].”
From Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology (2023) · cites this paper as [73]
In fully developed AD, all studies agree that the subiculum and the presubiculum show atrophic changes.
“all studies agree that the subiculum and the presubiculum show atrophic changes”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [33]
In fully developed AD, studies differ as to the pattern of volume reduction in Ammon's horn subfields.
“differ as to the pattern of the volume reduction in Ammon's horn subfields”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [33]
Previous neuroimaging studies obtained contrasting data regarding the pattern of hippocampal subfield atrophy in AD patients.
“Previous neuroimaging studies obtained contrasting data regarding the pattern of hippocampal subfield atrophy in AD patients.”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [33]
The CA1 subfield was found significantly atrophic in a study using the same automated method as ours and in studies using manual segmentation or 3D surface reconstruction, irrespective of dementia severity.
“the CA1 subfield was found significantly atrophic in a study that used the same automated method as ours and included patients with similar dementia severity [33] and in studies that used a procedure involving manual segmentation of hippocampal subfields [34], [35] or based on 3D surface reconstruction and shape analysis of the hippocampi [36], [37]”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [33]
Controversial data were obtained particularly in studies that relied on manual versus automated segmentation methods.
“As for the second point of concern, controversial data were obtained particularly in studies that relied on manual versus automated segmentation methods.”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [33]
The most critical issues explaining contrasting data regard the diagnostic criteria adopted in sample selection and the reliability of segmentation techniques for discriminating between individual hippocampal subfields.
“Probably, the most critical issues regard the diagnostic criteria adopted in sample selection and the reliability of the segmentation techniques used for discriminating between individual hippocampal subfields.”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [33]
The volume of the CA3 and CA4 subfields was found in the normal range in most studies using manual segmentation and 3D surface reconstruction but was invariably atrophic in studies based on automated segmentation procedures.
“Conversely, the volume of the CA3 and CA4 subfields was found in the normal range in most of the studies that used manual segmentation [34], [35] and 3D surface reconstruction and shape analysis [36] but was invariably atrophic in studies based on automated segmentation procedures [31], [33].”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [33]
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References 45 · Cited by 42
- Authors
- Li, Y.-D., Dong, H.-B., Xie, G.-M., & Zhang, L.-J.
- Affiliations
- Ningbo University (CN)
- Department of Radiology, Lihuili Hospital of Ningbo Medical Center, Ningbo University, Ningbo, Zhejiang, China
- College of Science & Technology, Ningbo University, Ninbo, Zhejiang, China
- Venue
- American Journal of Alzheimer's Disease & Other Dementias®
- Publisher
- SAGE Publications
- Published
- 2013-06-29
- Volume
- 28
- Issue
- 6
- Pages
- 627-633
- ISSN
- 0888-4897 (ISSN-L)
- 1533-3175
- 1938-2731
- PMC
- PMC10852725
- OpenAlex
- W2121935833
- Cited by
- 42
- References
- 45
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 5
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Alzheimer s Disease & Other Dementias® (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- mild Alzheimer's disease, normal aging, hippocampal subfields, CA1, subiculum, hippocampal atrophy, diffusion tensor imaging, differential diagnosis, early detection of Alzheimer's disease
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Atrophy, Cognition Disorders, Female, Hippocampus, Humans, Male, Middle Aged, ROC Curve, Severity of Illness Index, Diffusion Tensor Imaging, CA1 Region, Hippocampal
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