Magnesium Status in Alzheimer’s Disease: A Systematic Review
Open accessAbstract
The interest in poor magnesium (Mg) status as risk factor for Alzheimer's disease (AD) is increasing due to its antioxidant and neuroprotective properties. A systematic PubMed literature search of studies investigating Mg status was undertaken comparing AD to healthy controls (HCs) or patients with medical illness (medical controls [MCs]). Standardized mean differences (SMDs) ± 95% confidence intervals (CIs) were calculated for all outcomes. Of 192 potentially eligible studies, 13 were included (559 patients with AD, 381 HCs, and 126 MCs). Compared to HCs, patients with AD had significantly lower Mg in cerebrospinal fluid (2 studies; SMD = -0.35;P= .02) and in hair (2 studies; SMD = -0.75;P= .0001). No differences between AD and controls were evident for serum Mg. In conclusion, AD seems to be associated with a lower Mg status when compared to HCs, while the scarcity of studies limited the findings about MCs.
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In a review of observational studies comparing 559 subjects with Alzheimer disease with 381 healthy matched controls, lower magnesium concentration in cerebrospinal fluid was found in Alzheimer disease.
“In a review of observational studies comparing magnesium status in a total of 559 subjects suffering from Alzheimer disease, a lower magnesium concentration in the cerebrospinal fluid was found, when compared with 381 healthy matched controls [186].”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [186]
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References 48 · Cited by 64
Research works printed but not linked: 2
- Lemke MR. Plasma magnesium decrease and altered calcium/ magnesium ratio in severe dementia of the Alzheimer type. Biol Psychiatry. 1993;37(5):341-343.
- Barbagallo M, Belvedere M, Dominguez LJ. Magnesium home- ostasis and aging. Magnes Res. 2009;22(4):235-246.
- Authors
- Veronese, N., Zurlo, A., Solmi, M., Luchini, C., Trevisan, C., Bano, G., Manzato, E., Sergi, G., & Rylander, R.
- Affiliations
- University of Padua (IT)
- University of Verona (IT)
- BioFact Environmental Health Research Center (SE)
- ORCID
- Venue
- American Journal of Alzheimer's Disease & Other Dementias®
- Publisher
- SAGE Publications
- Published
- 2015-09-07
- Volume
- 31
- Issue
- 3
- Pages
- 208-213
- ISSN
- 0888-4897 (ISSN-L)
- 1533-3175
- 1938-2731
- PMC
- PMC10852887
- OpenAlex
- W2143858230
- Cited by
- 64
- References
- 48
- Citations by year
- 2026: 2 · 2024: 12 · 2023: 4 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 9 · 2017: 5 · 2016: 1 · 2015: 1
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Alzheimer s Disease & Other Dementias® (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- magnesium status, Alzheimer's disease, cerebrospinal fluid magnesium, serum magnesium, hypomagnesemia, antioxidant activity, neuroprotection, biomarkers
- MeSH terms
- Alzheimer Disease, Humans, Magnesium
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