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Cited by 11Regulation of Appetite and ObesityGrowth Hormone and Insulin-like Growth FactorsBirth, Development, and Health

Leptin Predicts Bone and Fat Mass after Accounting for the Effects of Diet and Glucocorticoid Treatment in Piglets 1

Weiler, Hope A., Kovacs, Heather, Murdock, Christine, Adolphe, Jennifer, Wong, Shirley Fitzpatrick·2002·Experimental Biology and Medicine
DOI 10.1177/153537020222700813
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Abstract

The role of leptin in neonatal growth and bone metabolism has been investigated, but not simultaneously. The objectives of this study were to determine if leptin relates to bone mass during rapid growth; if consumption of maternal milk is related to elevated circulating concentrations of leptin resulting in higher fat mass; and if glucocorticoids result in higher fat mass and reduced bone mass due to elevated leptin. Thirty-two piglets were randomized to either a suckling or milk substitute plus either dexamethasone (DEX) or placebo injection for 15 days beginning at 5 days of age. Milk and blood samples were obtained at baseline, and after 15 days, blood was sampled again for measurement of leptin and bone biochemistry. Weight at baseline plus weight and length after 15 days were recorded, followed by measurement of whole body bone mineral content, bone area, and fat mass using dual energy x-ray absorptiometry. At baseline, plasma leptin was elevated in suckled piglets. Piglets that suckled had elevated fat mass as did those who received DEX. However, DEX resulted in suppressed weight and length, bone mass, and bone metabolism. Leptin was similar among groups after the 15 days. After accounting for body size and treatment effects, piglet plasma leptin was predictive of bone and fat mass. Leptin circulating early postnatally is linked to body composition, specifically fat and bone mass. Elevations in fat mass and reductions in bone mass observed after 15 days of DEX treatment are not related to leptin metabolism. Both human and porcine neonates share similar characteristics with respect to relationships of leptin with fat and bone mass.

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Crossref · 10.1177/153537020222700813

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  • In animal studies, excess glucocorticoid exposure in utero consistently programmes the offspring for increased adiposity.

    “In animal studies, excess glucocorticoid exposure in utero was consistently shown to programme the offspring for increased adiposity (Table 6 and [119–123]).”

    From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [123]

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Authors
Weiler, H. A., Kovacs, H., Murdock, C., Adolphe, J., & Wong, S. F.
Affiliations
University of Manitoba (CA)
Corresponding author
Weiler, Hope A.
ORCID
Venue
Experimental Biology and Medicine
Publisher
Frontiers Media SA
Published
2002-09
Volume
227
Issue
8
Pages
639-644
ISSN
  • 0071-3384 (ISSN-L)
  • 1535-3702
  • 1535-3699
DOI
10.1177/153537020222700813
OpenAlex
W2166042314
Cited by
11
References
38
Citations by year
2023: 1 · 2021: 1 · 2012: 2
FWCI
0.21
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Experimental Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
leptin, bone mass, fat mass, neonatal growth, piglets, dexamethasone, glucocorticoids, suckling, dairy alternatives, bone mineral content, body composition, bone metabolism
MeSH terms
Adipose Tissue, Animals, Animal Feed, Body Composition, Body Weight, Bone and Bones, Dexamethasone, Male, Milk, Minerals, Organ Size, Random Allocation, Species Specificity, Swine, Weight Gain, Bone Density, Leptin, Models, Animal

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