The DOI matches its Crossref record; 189 of the 189 references it cites were found in a registry or an index.
Mechanisms of liver fibrosis and its role in liver cancer
Open accessAbstract
Hepatic fibrogenesis is a pathophysiological outcome of chronic liver injury hallmarked by excessive accumulation of extracellular matrix proteins. Fibrosis is a dynamic process that involves cross-talk between parenchymal cells (hepatocytes), hepatic stellate cells, sinusoidal endothelial cells and both resident and infiltrating immune cells. In this review, we focus on key cell-types that contribute to liver fibrosis, cytokines, and chemokines influencing this process and what it takes for fibrosis to regress. We discuss how mitochondria and metabolic changes in hepatic stellate cells modulate the fibrogenic process. We also briefly review how the presence of fibrosis affects development of hepatocellular carcinoma. Impact statement: Advanced liver fibrosis results in cirrhosis, portal hypertension, and liver failure and often requires liver transplantation. Advanced liver fibrosis and cirrhosis are also major risk factors for hepatocellular carcinoma (HCC). Hepatic stellate cells (HSCs) play a pivotal role in the pathogenesis of liver fibrosis. In this review, we summarize the basic mechanisms that influence liver fibrosis development and how oxidative stress, mitochondrial dysfunction, and metabolic remodeling modulate HSC activation and indicate areas of potential therapeutic intervention.
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Cited by
The immunological and metabolic landscape in primary and metastatic liver cancer
Li, X., Ramadori, P., Pfister, D., Seehawer, M., Zender, L., & Heikenwalder, M. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-021-00383-9 · Cited by 616
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Metadata
- Authors
- Dhar, D., Baglieri, J., Kisseleva, T., & Brenner, D. A.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 2020-01
- Volume
- 245
- Issue
- 2
- Pages
- 96-108
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W3000585291
- Cited by
- 429
- References
- 189
- FWCI
- 23.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Licence
- journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
- Funders
- NIH/UCSD (1KL2TR001444)
- NIH/NIEHS Superfund core (P42ES010337)
- NIH/NIAAA/USC (P50AA011999)
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- Dhar, D., Baglieri, J., Kisseleva, T., & Brenner, D. A. (2020). Mechanisms of liver fibrosis and its role in liver cancer. Experimental Biology and Medicine. https://doi.org/10.1177/1535370219898141
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
