The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Resolution of Inflammation: A New Paradigm for the Pathogenesis of Periodontal Diseases
Abstract
The periodontal diseases are infectious diseases caused by predominantly Gram-negative bacteria. However, as our understanding of the pathogenesis of the periodontal diseases grows, it is becoming clear that most of the tissue damage that characterizes periodontal disease is caused by the host response to infection, not by the infectious agent directly. Investigation into the mechanism of action of host-mediated tissue injury has revealed that the neutrophil plays an important role in destruction of host tissues. In this paper, we review the biochemical pathways and molecular mediators that are responsible for regulation of the inflammatory response in diseases such as periodontitis, with a focus on lipid mediators of inflammation. Pro-inflammatory mediators, such as prostaglandins and leukotrienes, are balanced by counter-regulatory signals provided by a class of molecules called lipoxins. The role of lipoxins in the control and resolution of inflammation is discussed, as is the possibility of the development of new therapeutic strategies for the control and prevention of neutrophil-mediated tissue injury in inflammatory diseases like periodontitis.
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Citations
Cites
Tissue Destruction by Neutrophils
Epstein, F. H., & Weiss, S. J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902093200606 · Cited by 3,950
Lipid mediator class switching during acute inflammation: signals in resolution
Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001) · Nature Immunology · doi:10.1038/89759 · Cited by 1,453
Self-citation
Cited by
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932
Self-citationKinane, D. F., Stathopoulou, P. G., & Papapanou, P. N. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.38 · Cited by 2,724
Inflammatory and immune pathways in the pathogenesis of periodontal disease
Cekici, A., Kantarci, A., Hasturk, H., & Van Dyke, T. E. (2014) · Periodontology 2000 · doi:10.1111/prd.12002 · Cited by 1,415
“A 5-, 12- or 15-S-hydroxy-(p)-eicosatetraenoic acid intermediate is produced, which is then further acted on by 15-lipoxygenase to induce the synthesis of doubly substituted intermediates (5, 15 hydroxy-(p)eicosatetraenoic acids, for example) that are further metabolized into lipoxins, such as lipoxins A4 and B4 (109,…”
BackgroundInflammatory Resolution: new opportunities for drug discovery
Gilroy, D. W., Lawrence, T., Perretti, M., & Rossi, A. G. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1383 · Cited by 772
The role of the microbiota in periodontal disease
Curtis, M. A., Diaz, P. I., & Van Dyke, T. E. (2020) · Periodontology 2000 · doi:10.1111/prd.12296 · Cited by 698
Metadata
- Authors
- Van Dyke, T. E., & Serhan, C. N.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2003-02
- Volume
- 82
- Issue
- 2
- Pages
- 82-90
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2013144840
- Cited by
- 513
- References
- 2
- FWCI
- 26.09
- Type
- journal article
- Language
- en
- Open access
- closed
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