The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Implant Surface Roughness Affects Osteoblast Gene Expression
Abstract
The transcription factor Cbfa1 regulates osteoblast differentiation and expression of genes necessary for the development of a mineralized phenotype. The purpose of this study was to determine if Cbfa1 and BSPII gene expression are influenced by implant surface microtopography. Osteoblasts were cultured on 600-grit (grooved) or sandblasted (roughened) cpTi implant discs. Mineralization was evaluated by Alizarin-Red-S staining. Real Time PCR was used for quantitative analysis of Cbfa1 and BSPII gene expression. Enhanced mineralization was seen in osteoblasts grown on roughened implant surfaces relative to tissue culture plastic. Real Time PCR showed significant (P < 0.05) increases in Cbfa1 gene expression in cells grown on roughened, as compared with grooved, implant surfaces. BSPII gene expression was also increased on rough surfaces in the UMR cells, but was reduced in the rat calvarial osteoblast cultures. These results suggest that osteoblast gene expression and mineralization are affected by roughened implant surface microtopographies during osseointegration of dental implants.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246
Cited by
Advancing dental implant surface technology – From micron- to nanotopography
Mendonça, G., Mendonça, D. B. S., Aragão, F. J. L., & Cooper, L. F. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.05.012 · Cited by 990
Zirconia dental implants: where are we now, and where are we heading?
Cionca, N., Hashim, D., & Mombelli, A. (2017) · Periodontology 2000 · doi:10.1111/prd.12180 · Cited by 300
The development and future of dental implants
ALGHAMDI, H. S., & JANSEN, J. A. (2020) · Dental Materials Journal · doi:10.4012/dmj.2019-140 · Cited by 253
Metadata
- Authors
- Schneider, G. B., Perinpanayagam, H., Clegg, M., Zaharias, R., Seabold, D., Keller, J., & Stanford, C.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2003-05
- Volume
- 82
- Issue
- 5
- Pages
- 372-376
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2030347996
- Cited by
- 209
- References
- 1
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Implant Surface Roughness Affects Osteoblast Gene Expression. https://app.cochat.ai/papers/10.1177/154405910308200509
- The paper
- Schneider, G. B., Perinpanayagam, H., Clegg, M., Zaharias, R., Seabold, D., Keller, J., & Stanford, C. (2003). Implant Surface Roughness Affects Osteoblast Gene Expression. Journal of Dental Research. https://doi.org/10.1177/154405910308200509
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
