Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

Otto, F., Thornell, A., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G., Beddington, R. S. P., Mundlos, S., Olsen, B. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80259-7 · Cited by 2,813 · see citing works

Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein

Luo, G., Ducy, P. F., McKee, M. D., Pinero, G. J., Loyer, E. M., Behringer, R. R., & Karsenty, G. (1997) · Nature · doi:10.1038/386078a0 · Cited by 2,118 · see citing works

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.Preprint

Hogan, B. L. M. (1996) · Genes & Development · doi:10.1101/gad.10.13.1580 · Cited by 1,964 · see citing works

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.Preprint

Kingsley, D. M. (1994) · Genes & Development · doi:10.1101/gad.8.2.133 · Cited by 1,920 · see citing works

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.

Okuda, T., van Deursen, J., Hiebert, S. W., Grosveld, G., & Downing, J. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80986-1 · Cited by 1,856 · see citing works

The Atlas of Mouse Development

Kaufman, M. H. (1992) · Medical Entomology and Zoology · Cited by 1,749 · see citing works

Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

Mundlos, S., Otto, F., Mundlos, C., Mulliken, J. B., Aylsworth, A. S., Albright, S. G., Lindhout, D., Cole, W. G., Henn, W., Knoll, J. H. M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80260-3 · Cited by 1,502 · see citing works

Adipogenesis and Obesity: Rounding Out the Big Picture

Spiegelman, B. M., & Flier, J. S. (1996) · Cell · doi:10.1016/s0092-8674(00)81359-8 · Cited by 1,254 · see citing works

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.Preprint

Karaplis, A. C., Luz, A., Glowacki, J., Bronson, R. T., Tybulewicz, V. L. J., Kronenberg, H. M., & Mulligan, R. C. (1994) · Genes & Development · doi:10.1101/gad.8.3.277 · Cited by 1,151 · see citing works

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

Piccolo, S., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Cell · doi:10.1016/s0092-8674(00)80132-4 · Cited by 1,127 · see citing works

Connective Tissue and Its Heritable Disorders

Heinegård, D., Aspberg, A., Franzén, A., & Lorenzo, P. (2002) · Wiley eBooks · doi:10.1002/0471221929 · Cited by 946 · see citing works

Bone and haematopoietic defects in mice lacking c-fos

Wang, Z., Ovitt, C. E., Grigoriadis, A. E., Möhle-Steinlein, U., Rüther, U., & Wagner, E. F. (1992) · Nature · doi:10.1038/360741a0 · Cited by 932 · see citing works

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

Johnson, R. S., Spiegelman, B. M., & Papaioannou, V. E. (1992) · Cell · doi:10.1016/0092-8674(92)90592-z · Cited by 630 · see citing works

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

Ogawa, E., Maruyama, M., Kagoshima, H., Inuzuka, M., Lu, J., Satake, M., Shigesada, K., & Ito, Y. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6859 · Cited by 608 · see citing works

Two Distinct Osteoblast-Specific cis-Acting Elements Control Expression of a Mouse Osteocalcin Gene

Ducy, P. F., & Karsenty, G. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.1858 · Cited by 570 · see citing works

Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors.

Molkentin, J. D., & Olson, E. N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9366 · Cited by 420 · see citing works

A transcriptional hierarchy involved in mammalian cell-type specification

Kuo, C. J., Conley, P. B., Chen, L., Sladek, F. M., Darnell, J. E., Jr., & Crabtree, G. R. (1992) · Nature · doi:10.1038/355457a0 · Cited by 413 · see citing works

The runt domain identifies a new family of heterometric transcriptional regulators

Kagoshima, H., Shigesada, K., Satake, M., Ito, Y., Miyoshi, H., Ohki, M., Pepling, M., & Gergen, P. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90026-e · Cited by 326 · see citing works

Development of adynamic bone in patients with secondary hyperparathyroidism after intermittent calcitriol therapy

Goodman, W. G., Ramirez, J. A., Belin, T. R., Chon, Y., Gales, B., Segre, G. V., & Salusky, I. B. (1994) · Kidney International · doi:10.1038/ki.1994.380 · Cited by 318 · see citing works

The Tissue-Specific Nuclear Matrix Protein, NMP-2, Is a Member of the AML/PEBP2/Runt Domain Transcription Factor Family: Interactions with the Osteocalcin Gene Promoter

Merriman, H. L., van Wijnen, A. J., Hiebert, S. W., Bidwell, J. P., Fey, E. G., Lian, J. B., Stein, J. L., & Stein, G. S. (1995) · Biochemistry · doi:10.1021/bi00040a025 · Cited by 247 · see citing works

Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1.

Bae, S. C., Yamaguchi‐Iwai, Y., Ogawa, E., Maruyama, M., Inuzuka, M., Kagoshima, H., Shigesada, K., Satake, M., & Ito, Y. (1993) · PubMed · Cited by 228 · see citing works

A PEBP2α/AML-1-related Factor Increases Osteocalcin Promoter Activity through Its Binding to an Osteoblast-specific cis-Acting Element

Geoffroy, V., Ducy, P. F., & Karsenty, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.52.30973 · Cited by 169 · see citing works

A New Transcription Factor Family Associated with Human Leukemias

Speck, N. A., & Stacy, T. (1995) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v5.i3-4.60 · Cited by 163 · see citing works

Expression of the Runt Domain-Encoding PEBP2 α Genes in T cells during Thymic Development

Satake, M., Nomura, S., Yamaguchi‐Iwai, Y., Takahama, Y., Hashimoto, Y., Niki, M., Kitamura, Y., & Ito, Y. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.3.1662 · Cited by 157 · see citing works

Limbs: a model for pattern formation within the vertebrate body plan

Cohn, M. J., & Tickle, C. A. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)10030-5 · Cited by 151 · see citing works

Genetic mapping of cleidocranial dysplasia and evidence of a microdeletion in one family

Mundlos, S., Mulliken, J. B., Abramsom, D. L., Warman, M. L., Knoll, J. H. M., & Olsen, B. R. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.1.71 · Cited by 117 · see citing works

The evolution of genomic imprinting

Chandra, H. S., & Nanjundiah, V. (1990) · Development · doi:10.1242/dev.108.supplement.47 · Cited by 115 · see citing works

1,25-Dihydroxyvitamin D3 Inhibits Osteocalcin Expression in Mouse through an Indirect Mechanism

Zhang, R., Ducy, P. F., & Karsenty, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.110 · Cited by 112 · see citing works

The localized requirements for a gene affecting segmentation in Drosophila: Analysis of larvae mosaic for runt

Gergen, J. P., & Wieschaus, E. F. (1985) · Developmental Biology · doi:10.1016/0012-1606(85)90459-2 · Cited by 108 · see citing works

Upstream regulatory elements necessary for expression of the rat COL1A1 promoter in transgenic mice

Bogdanovic, Z., Bedalov, A., Krebsbach, P. H., Pavlin, D., Woody, C. O., Clark, S. H., Thomas, H. F., Rowe, D. W., Kream, B. E., & Lichtler, A. C. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090218 · Cited by 103 · see citing works

Identification of a minimal sequence of the mouse pro-alpha 1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts.

Rossert, J., Chen, S. S., Eberspaecher, H., Smith, C. N., & Crombrugghe, B. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1027 · Cited by 102 · see citing works

Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs.

Towler, D. A., Bennett, C. D., & Rodan, G. A. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.5.7914673 · Cited by 98 · see citing works

Expression of runt in the mouse embryo

Simeone, A., Daga, A., & Calabi, F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030107 · Cited by 73 · see citing works

Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter

Wijmenga, C., Speck, N. A., Dracopoli, N. C., Hofker, M. H., Liu, P., & Collins, F. S. (1995) · Genomics · doi:10.1016/0888-7543(95)80185-o · Cited by 47 · see citing works

Regulation of COL1A1 expression in type I collagen producing tissues: Identification of a 49 base pair region which is required for transgene expression in bone of transgenic mice

Bedalov, A., Salvatori, R., Dodig, M., Kronenberg, M. S., Kapural, B., Bogdanovic, Z., Kream, B. E., Woody, C. O., Clark, S. H., Mack, K., et al. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650101004 · Cited by 46 · see citing works

A ubiquitous repressor interacting with an F9 cell-specific silencer and its functional suppression by differentiated cell-specific positive factors.

Furukawa, K., Yamaguchi, Y., Ogawa, E., Shigesada, K., Satake, M., & Ito, Y. (1990) · PubMed · Cited by 43 · see citing works

Animal model: Skeletal anomalies in mice with cleidocranial dysplasia

Sillence, D. O., Ritchie, H. E., Selby, P. B., & Prieur, D. J. (1987) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320270109 · Cited by 42 · see citing works

Identification of the mouse pro-α1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts

Rossert, J. (1996) · Medical Entomology and Zoology · Cited by 34 · see citing works

Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs

Towler, D. A. (1994) · Molecular Endocrinology · doi:10.1210/me.8.5.614 · Cited by 33 · see citing works

Identification of a minimal sequence of the mouse Pro-α1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts

Rossert, J., Chen, S. S., Nakashima, K., Eberspaecher, H., Smith, C. N., & Crombrugghe, B. D. (1996) · Matrix Biology · doi:10.1016/s0945-053x(96)90093-1 · Cited by 9 · see citing works

Human Adipose Tissue Is a Source of Multipotent Stem Cells

Zuk, P. A., Zhu, M., Ashjian, P. H., Ugarte, D. A. D., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,669 · see citing works

Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)

Stöckl, S., Göttl, C., Grifka, J. K., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,670 · see citing works

The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation

Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608 · see citing works

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis

Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0395 · Cited by 2,575 · see citing works

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044 · see citing works

Bone Marrow Stromal Stem Cells: Nature, Biology, and Potential Applications

Bianco, P., Riminucci, M., Gronthos, S., & Robey, P. G. (2001) · Stem Cells · doi:10.1634/stemcells.19-3-180 · Cited by 1,944 · see citing works

Functions of RANKL/RANK/OPG in bone modeling and remodeling

Boyce, B. F., & Xing, L. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.018 · Cited by 1,844 · see citing works

Pathogenesis of osteoporosis: concepts, conflicts, and prospects

Raisz, L. G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci27071 · Cited by 1,779 · see citing works

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

Vu, T. H., Shipley, J. M., Bergers, G., Berger, J. E., Helms, J. A., Hanahan, D., Shapiro, S. D., Senior, R. M., & Werb, Z. (1998) · Cell · doi:10.1016/s0092-8674(00)81169-1 · Cited by 1,737 · see citing works

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formationPreprint

St‐Jacques, B., Hammerschmidt, M., & McMahon, A. P. (1999) · Genes & Development · doi:10.1101/gad.13.16.2072 · Cited by 1,742 · see citing works

Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis

Day, T. F., Guo, X., Garrett-Beal, L., & Yang, Y. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.016 · Cited by 1,616 · see citing works

Reaching a Genetic and Molecular Understanding of Skeletal Development

Karsenty, G., & Wagner, E. F. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00157-0 · Cited by 1,594 · see citing works

Mutations in NOTCH1 cause aortic valve disease

Garg, V., Muth, A. N., Ransom, J. F., Schluterman, M. K., Barnes, R., King, I. N., Grossfeld, P. D., & Srivastava, D. (2005) · Nature · doi:10.1038/nature03940 · Cited by 1,509 · see citing works

Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

Mundlos, S., Otto, F., Mundlos, C., Mulliken, J. B., Aylsworth, A. S., Albright, S. G., Lindhout, D., Cole, W. G., Henn, W., Knoll, J. H. M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80260-3 · Cited by 1,502 · see citing works

Perivascular Niche of Postnatal Mesenchymal Stem Cells in Human Bone Marrow and Dental Pulp

Shi, S., & Gronthos, S. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.4.696 · Cited by 1,479 · see citing works

Control of osteoblast function and regulation of bone mass

Harada, S.-I., & Rodan, G. A. (2003) · Nature · doi:10.1038/nature01660 · Cited by 1,451 · see citing works

Phosphate Regulation of Vascular Smooth Muscle Cell Calcification

Jono, S., McKee, M. D., Murry, C. E., Shioi, A., Nishizawà, Y., Mori, K., Morii, H., & Giachelli, C. M. (2000) · Circulation Research · doi:10.1161/01.res.87.7.e10 · Cited by 1,425 · see citing works

Minireview: The OPG/RANKL/RANK System

Khosla, S. (2001) · Endocrinology · doi:10.1210/endo.142.12.8536 · Cited by 1,515 · see citing works

Bone Remodeling

Hadjidakis, D., & Androulakis, I. I. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1365.035 · Cited by 1,408 · see citing works

BIOMECHANICAL AND MOLECULAR REGULATION OF BONE REMODELING

Robling, A. G., Castillo, A. B., & Turner, C. H. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095721 · Cited by 1,343 · see citing works

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

Holmbeck, K., Bianco, P., Caterina, J., Yamada, S., Kromer, M., Kuznetsov, S. A., Mankani, M., Gehron Robey, P., Poole, A. R., Pidoux, I., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80064-1 · Cited by 1,298 · see citing works

Mechanisms of bone development and repair

Salhotra, A., Shah, H. N., Lévi, B., & Longaker, M. T. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00279-w · Cited by 1,243 · see citing works

Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression

Gaur, T., Lengner, C. J., Hovhannisyan, H., Bhat, R. A., Bodine, P. V. N., Komm, B. S., Javed, A., van Wijnen, A. J., Stein, J. L., Stein, G. S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500608200 · Cited by 1,170 · see citing works

Mesenchymal stem cells: building blocks for molecular medicine in the 21st century

Caplan, A. I., & Bruder, S. P. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02016-0 · Cited by 1,138 · see citing works

The Osteoblast: A Sophisticated Fibroblast under Central Surveillance

Ducy, P. F., Schinke, T., & Karsenty, G. (2000) · Science · doi:10.1126/science.289.5484.1501 · Cited by 1,121 · see citing works

Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism

Ferron, M., Wei, J., Yoshizawa, T., Del Fattore, A., DePinho, R. A., Teti, A., Ducy, P., & Karsenty, G. (2010) · Cell · doi:10.1016/j.cell.2010.06.003 · Cited by 1,123 · see citing works

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099 · see citing works

The control of chondrogenesis

Goldring, M. B., Tsuchimochi, K., & Ijiri, K. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20652 · Cited by 1,062 · see citing works

Regulation of osteoblast differentiation by transcription factors

Komori, T. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20958 · Cited by 1,027 · see citing works

Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow

Gronthos, S., Zannettino, A. C. W., Hay, S. J., Shi, S., Graves, S. E., Kortesidis, A., & Simmons, P. J. (2003) · Journal of Cell Science · doi:10.1242/jcs.00369 · Cited by 1,025 · see citing works

Distinct roles for Hedgehog and canonical Wnt signaling in specification,differentiation and maintenance of osteoblast progenitors

Rodda, S. J., & McMahon, A. P. (2006) · Development · doi:10.1242/dev.02480 · Cited by 1,011 · see citing works

TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation

Hong, J.-H., Hwang, E. S., McManus, M. T., Amsterdam, A., Tian, Y., Kalmukova, R., Mueller, E., Benjamin, T., Spiegelman, B. M., Sharp, P. A., et al. (2005) · Science · doi:10.1126/science.1110955 · Cited by 1,009 · see citing works

Identification and Characterization of a Novel Protein, Periostin, with Restricted Expression to Periosteum and Periodontal Ligament and Increased Expression by Transforming Growth Factor β

Horiuchi, K., Amizuka, N., Takeshita, S., Takamatsu, H., Katsuura, M., Ozawa, H., Toyama, Y., Bonewald, L. F., & Kudō, A. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.7.1239 · Cited by 975 · see citing works

Vascular Calcification

Johnson, R. C., Leopold, J. A., & Loscalzo, J. (2006) · Circulation Research · doi:10.1161/01.res.0000249379.55535.21 · Cited by 940 · see citing works

Mesenchymal Stem Cells

Ding, D., Shyu, W., & Lin, S. (2011) · Cell Transplantation · doi:10.3727/096368910x · Cited by 915 · see citing works

Age-Related Osteogenic Potential of Mesenchymal Stromal Stem Cells from Human Vertebral Bone Marrow

D’Ippolito, G., Schiller, P. C., Ricordi, C., Roos, B. A., & Howard, G. A. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.7.1115 · Cited by 906 · see citing works

FGF signaling pathways in endochondral and intramembranous bone development and human genetic diseasePreprint

Ornitz, D. M., & Marie, P. J. (2002) · Genes & Development · doi:10.1101/gad.990702 · Cited by 902 · see citing works

How the ageing microenvironment influences tumour progression

Fane, M., & Weeraratna, A. T. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0222-9 · Cited by 849 · see citing works

Mesenchymal Stem Cells

Minguell, J. J., Erices, A. A., & Conget, P. A. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122600603 · Cited by 876 · see citing works

Runx2 Is a Common Target of Transforming Growth Factor β1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12

Lee, K., Kim, H., Li, Q., Chi, X., Ueta, C., Komori, T., Wozney, J. M., Kim, E., Choi, J.-Y., Ryoo, H., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8783-8792.2000 · Cited by 867 · see citing works

Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton

CANALIS, E. M., Economides, A. N., & Gazzerro, E. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0023 · Cited by 861 · see citing works

Muscle satellite cells are multipotential stem cells that exhibit myogenic, osteogenic, and adipogenic differentiation

Asakura, A., Rudnicki, M. A., & Komaki, M. (2001) · Differentiation · doi:10.1046/j.1432-0436.2001.680412.x · Cited by 839 · see citing works

Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis

Justesen, J., Stenderup, K., Ebbesen, E., Mosekilde, L., Steiniche, T., & Kassem, M. (2004) · Biogerontology (Dordrecht) · doi:10.1023/a:1011513223894 · Cited by 847 · see citing works

Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR‐γ2 transcription factor and TGF‐β/BMP signaling pathways

Moerman, E., Teng, K., Lipschitz, D., & Lecka-Czernik, B. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00127.x · Cited by 840 · see citing works

Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2

Komori, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071694 · Cited by 829 · see citing works

Bone Development

Olsen, B. R., Reginato, A. M., & Wang, W. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.191 · Cited by 828 · see citing works

Smooth Muscle Cell Phenotypic Transition Associated With Calcification

Steitz, S. A., Speer, M. Y., Curinga, G., Yang, H.-Y. L., Haynes, P. A., Aebersold, R. H., Schinke, T., Karsenty, G., & Giachelli, C. M. (2001) · Circulation Research · doi:10.1161/hh2401.101070 · Cited by 823 · see citing works

ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology

Yang, X., Matsuda, K., Bialek, P., Jacquot, S., Masuoka, H. C., Schinke, T., Li, L., Brancorsini, S., Sassone‐Corsi, P., Townes, T. M., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00344-7 · Cited by 822 · see citing works

Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets

Hideshima, T., Mitsiades, C., Tonon, G., Richardson, P. G., & Anderson, K. C. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2189 · Cited by 932 · see citing works

Regulation of bone development and extracellular matrix protein genes by RUNX2

Komori, T. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0832-8 · Cited by 806 · see citing works

Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis

Vega, R. B., Matsuda, K., Oh, J., Barbosa, A. C. C., Yang, X., Meadows, E., McAnally, J., Pomajzl, C., Shelton, J. M., Richardson, J. A., et al. (2004) · Cell · doi:10.1016/j.cell.2004.10.024 · Cited by 805 · see citing works

Buried alive: How osteoblasts become osteocytes

Franz‐Odendaal, T. A., Hall, B. K., & Witten, P. E. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20603 · Cited by 795 · see citing works

Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors

Vincenti, M. P., & Brinckerhoff, C. E. (2002) · Arthritis Research & Therapy · doi:10.1186/ar401 · Cited by 796 · see citing works

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

McMurray, R. J., Gadegaard, N., Tsimbouri, P. M., Burgess, K., McNamara, L. E., Tare, R. S., Murawski, K., Kingham, E., Oreffo, R. O. C., & Dalby, M. J. (2011) · Nature Materials · doi:10.1038/nmat3058 · Cited by 779 · see citing works

Adult mesenchymal stem cells and cell-based tissue engineering.

Tuan, R. S., Boland, G. M., & Tuli, R. (2003) · Arthritis Research · doi:10.1186/ar614 · Cited by 780 · see citing works

Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T., & Matsuo, K. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.012 · Cited by 777 · see citing works

A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic developmentPreprint

Ducy, P. F., Starbuck, M., Priemel, M., Shen, J., Pinero, G. J., Geoffroy, V., Amling, M., & Karsenty, G. (1999) · Genes & Development · doi:10.1101/gad.13.8.1025 · Cited by 772 · see citing works

OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism

Walsh, M. C., Kim, N., Kadono, Y., Rho, J., Lee, S. Y., Lorenzo, J., & Choi, Y. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090646 · Cited by 724 · see citing works

Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

Taniuchi, I., Osato, M., Egawa, T., Sunshine, M. J., Bae, S., Komori, T., Ito, Y., & Littman, D. R. (2002) · Cell · doi:10.1016/s0092-8674(02)01111-x · Cited by 732 · see citing works

Leptin Acts on Human Marrow Stromal Cells to Enhance Differentiation to Osteoblasts and to Inhibit Differentiation to Adipocytes1

Thomas, T., Gori, F., Khosla, S., Jensen, M. D., Burguera, B. G., & Riggs, B. L. (1999) · Endocrinology · doi:10.1210/endo.140.4.6637 · Cited by 725 · see citing works

Transforming Growth Factor-β1 to the Bone

Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0001 · Cited by 710 · see citing works

The bone remodelling cycle

Kenkre, J. E., & Bassett, J. H. D. (2018) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563218759371 · Cited by 719 · see citing works

Regulation of Osteoblast Differentiation Mediated by Bone Morphogenetic Proteins, Hedgehogs, and Cbfa1

Yamaguchi, A., Komori, T., & Suda, T. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.4.0403 · Cited by 688 · see citing works

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

Hu, H., Hilton, M. J., Tu, X., Yu, K., Ornitz, D. M., & Long, F. (2005) · Development · doi:10.1242/dev.01564 · Cited by 682 · see citing works

A Twist Code Determines the Onset of Osteoblast Differentiation

Bialek, P., Kern, B., Yang, X., Schrock, M., Šošić, D., Hong, N. A., Wu, H., Yu, K., Ornitz, D. M., Olson, E. N., et al. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00058-9 · Cited by 674 · see citing works

Genetic Control of Bone Formation

Karsenty, G., Kronenberg, H. M., & Settembre, C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113308 · Cited by 667 · see citing works

Isolation and Characterization of MC3T3-E1 Preosteoblast Subclones with Distinct In Vitro and In Vivo Differentiation/Mineralization Potential

Wang, D., Christensen, K., Chawla, K., Xiao, G., Krebsbach, P. H., & Franceschi, R. T. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.6.893 · Cited by 666 · see citing works

Signaling and transcriptional regulation in osteoblast commitment and differentiation

Huang, W. (2007) · Frontiers in bioscience · doi:10.2741/2296 · Cited by 649 · see citing works

Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

Worthley, D. L., Churchill, M., Compton, J. T., Tailor, Y. H., Rao, M., Si, Y., Levin, D. E., Schwartz, M. G., Uygur, A., Hayakawa, Y., et al. (2015) · Cell · doi:10.1016/j.cell.2014.11.042 · Cited by 635 · see citing works

Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche

Taichman, R. S. (2004) · Blood · doi:10.1182/blood-2004-06-2480 · Cited by 648 · see citing works

Making or Breaking the Heart: From Lineage Determination to Morphogenesis

Srivastava, D. (2006) · Cell · doi:10.1016/j.cell.2006.09.003 · Cited by 641 · see citing works

Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair

Zhang, X., Schwarz, E. M., Young, D. A., Puzas, J. E., Rosier, R. N., & O’Keefe, R. J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15681 · Cited by 641 · see citing works

Chronic Elevation of Parathyroid Hormone in Mice Reduces Expression of Sclerostin by Osteocytes: A Novel Mechanism for Hormonal Control of Osteoblastogenesis

Bellido, T., Ali, A., Gubrij, I. B., Plotkin, L. I., Fu, Q., O’Brien, C. A., Manolagas, S. C., & Jilka, R. L. (2005) · Endocrinology · doi:10.1210/en.2005-0239 · Cited by 640 · see citing works

Oxidative Stress Induces Vascular Calcification through Modulation of the Osteogenic Transcription Factor Runx2 by AKT Signaling

Byon, C. H., Javed, A., Dai, Q., Kappes, J. C., Clemens, T. L., Darley-Usmar, V. M., McDonald, J. M., & Chen, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800021200 · Cited by 639 · see citing works

Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis

Bandyopadhyay, A., Tsuji, K., Cox, K. A., Harfe, B. D., Rosen, V., & Tabin, C. J. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020216 · Cited by 625 · see citing works

The cell biology of bone metabolism

Datta, H. K., Ng, W. F., Walker, J. A., Tuck, S. P., & Varanasi, S. S. (2008) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.048868 · Cited by 614 · see citing works

Osteoblasts in prostate cancer metastasis to bone

Logothetis, C. J., & Lin, S.-H. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1528 · Cited by 613 · see citing works

Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors

Akiyama, H., Kim, J., Nakashima, K., Balmes, G. C., Iwai, N., Deng, J. M., Zhang, Z., Martin, J. F., Behringer, R. R., Nakamura, T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504750102 · Cited by 607 · see citing works

Mitotic Misregulation and Human Aging

Ly, D. H., Lockhart, D. J., Lerner, R. A., & Schultz, P. G. (2000) · Science · doi:10.1126/science.287.5462.2486 · Cited by 599 · see citing works

MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells

Ivey, K. N., Muth, A. N., Arnold, J., King, F. W., Yeh, R.-F., Fish, J. E., Hsiao, E. C., Schwartz, R. J., Conklin, B. R., Bernstein, H. S., et al. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.01.016 · Cited by 601 · see citing works

The Transcription Factors L-Sox5 and Sox6 Are Essential for Cartilage Formation

Smits, P. J., Li, P., Mandel, J., Zhang, Z., Deng, J. M., Behringer, R. R., Crombrugghe, B. D., & Lefèbvre, V. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00003-x · Cited by 600 · see citing works

Regulatory mechanisms of osteoblast and osteoclast differentiation.

Katagiri, T., & Takahashi, N. (2002) · Oral Diseases · doi:10.1034/j.1601-0825.2002.01829.x · Cited by 640 · see citing works

Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation

Li, Z., Hassan, M. Q., Jafferji, M., Aqeilan, R. I., Garzon, R., Croce, C. M., van Wijnen, A. J., Stein, J. L., Stein, G. S., & Lian, J. B. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809787200 · Cited by 589 · see citing works

Cellular biology of fracture healing

Bahney, C. S., Zondervan, R. L., Allison, P., Theologis, A., Ashley, J. W., Ahn, J., Miclau, T., Marcucio, R. S., & Hankenson, K. D. (2019) · Journal of Orthopaedic Research · doi:10.1002/jor.24170 · Cited by 577 · see citing works

Marrow stromal stem cells.

Bianco, P., & Robey, P. G. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10413 · Cited by 908 · see citing works

Role and regulation of RUNX2 in osteogenesis

Bruderer, M., Richards, R. G., Alini, M., & Stoddart, M. J. (2014) · European Cells and Materials · doi:10.22203/ecm.v028a19 · Cited by 577 · see citing works

Targeting the Wnt/β-Catenin Pathway to Regulate Bone Formation in the Adult Skeleton

Baron, R., & Rawadi, G. (2007) · Endocrinology · doi:10.1210/en.2007-0270 · Cited by 584 · see citing works

Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair

Zhang, X., Schwarz, E. M., Young, D. A., Puzas, J. E., Rosier, R. N., & O’Keefe, R. J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215681 · Cited by 576 · see citing works

Murine Gcm1 gene is expressed in a subset of placental trophoblast cells

Basyuk, E. I., Cross, J. C., Corbin, J., Nakayama, H., Hunter, P., Nait‐Oumesmar, B., & Lazzarini, R. A. (1999) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199904)214:4 · Cited by 148 · see citing works

Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia

Lee, B., Thirunavukkarasu, K., Zhou, L., Pastore, L., Baldini, A., Hecht, J. T., Geoffrey, V., Ducy, P. F., & Karsenty, G. (1997) · Nature Genetics · doi:10.1038/ng0797-307 · Cited by 567 · see citing works

Osteoimmunology: Interactions of the Bone and Immune System

Lorenzo, J., Horowitz, M. C., & Choi, Y. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0038 · Cited by 566 · see citing works

Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-κB

Bai, X., Lu, D., Bai, J., Zheng, H., Ke, Z.-Y., Li, X., & Luo, S.-Q. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.073 · Cited by 561 · see citing works

A WW domain‐containing Yes‐associated protein (YAP) is a novel transcriptional co‐activator

Yagi, R., Chen, L. F., Shigesada, K., Murakami, Y., & Ito, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.9.2551 · Cited by 553 · see citing works

Inhibition of Osteoblast Differentiation by Tumor Necrosis Factor-α*

Gilbert, L., He, X., Farmer, P., Boden, S., Kozlowski, M., Rubin, J., & Nanes, M. S. (2000) · Endocrinology · doi:10.1210/endo.141.11.7739 · Cited by 555 · see citing works

MAPK Pathways Activate and Phosphorylate the Osteoblast-specific Transcription Factor, Cbfa1

Xiao, G., Jiang, D., Thomas, P. E., Benson, M. D., Guan, K., Karsenty, G., & Franceschi, R. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4453 · Cited by 547 · see citing works

Regulation of the osteoblast‐specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways

Franceschi, R. T., & Xiao, G. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10369 · Cited by 540 · see citing works

Does adult fracture repair recapitulate embryonic skeletal formation?

Ferguson, C. M., Alpern, E., Miclau, T., & Helms, J. A. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00142-2 · Cited by 540 · see citing works

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

Stein, G. S., Lian, J. B., van Wijnen, A. J., Stein, J. L., Montecino, M. A., Javed, A., Zaidi, S. K., Young, D. W., Choi, J., & Pockwinse, S. M. (2004) · Oncogene · doi:10.1038/sj.onc.1207676 · Cited by 536 · see citing works

Bone Growth Factors

Mohan, S., & Baylink, D. J. (1991) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199102000-00004 · Cited by 533 · see citing works

TGF‐β‐induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

Alliston, T., Choy, L., Ducy, P., Karsenty, G., & Derynck, R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.9.2254 · Cited by 526 · see citing works

Transcriptional regulation of osteoblast differentiation during development

Karsenty, G. (1998) · Frontiers in bioscience · doi:10.2741/a326 · Cited by 39 · see citing works

Placental defects in ARNT-knockout conceptus correlate with localized decreases in VEGF-R2, Ang-1, and Tie-2

Abbott, B. D., & Buckalew, A. R. (2000) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999 · Cited by 69 · see citing works

Characterization of Osf1, an Osteoblast-specific Transcription Factor Binding to a Critical cis-acting Element in the MouseOsteocalcin Promoters

Schinke, T., & Karsenty, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30182 · Cited by 73 · see citing works

Mesenchymal Stem Cells and Osteoblast Differentiation

Aubin, J. E., & Triffitt, J. T. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50106-2 · Cited by 160 · see citing works

The Developmental Control of Osteoblast-Specific Gene Expression: Role of Specific Transcription Factors and the Extracellular Matrix Environment

Franceschi, R. T. (1999) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411990100010201 · Cited by 274 · see citing works