The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Alcohol Consumption Increases Periodontitis Risk
Abstract
Alcohol consumption impairs neutrophil, macrophage, and T-cell functions, increasing the likelihood of infections. We examined the association between alcohol consumption and periodontitis, prospectively, among 39,461 male health professionals aged 40 to 75 years and free of periodontitis at the start of follow-up. Alcohol intake was assessed at baseline and updated every 4 years by a food-frequency questionnaire. Periodontal disease status was self-reported and validated against radiographs. Multivariate analysis was adjusted for age, smoking, diabetes, body-mass index, physical activity, time period, and caloric intake. During 406,160 person-years of follow-up, there were 2125 cases of periodontitis. Compared with non-drinkers, the relative risk (95% confidence interval) among men reporting usual alcohol intake of 0.1-4.9 g/day was 1.24 (1.09, 1.42); 5.0 to 14.9 g/day, 1.18 (1.04, 1.35); 15 to 29.9 g/day, 1.18 (1.01, 1.38); and > 30 g/day, 1.27 (1.08, 1.49). The results suggest that alcohol consumption is an independent modifiable risk factor for periodontitis.
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“Such dysbiosis is prompted by various factors, including host diet, inflammatory responses, systemic disruptions, and habits such as alcohol intake, smoking tobacco and consuming alcohol.50, 180, 181, 182, 183, 184, 185, 186”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [186]
Citations
Cites
Periodontal Diseases: Pathogenesis
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Self-citationCONSEQUENCES OF ALCOHOL CONSUMPTION ON HOST DEFENCE
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Prospective Study of Moderate Alcohol Consumption and Mortality in US Male Physicians
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The Effect of Alcohol Consumption on Periodontal Disease
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Association of lifestyle with periodontal health
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Petersen, P., & Ogawa, H. (2012) · Periodontology 2000 · doi:10.1111/j.1600-0757.2011.00425.x · Cited by 815
The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755
Strengthening the Prevention of Periodontal Disease: The WHO Approach
Petersen, P. E., & Ogawa, H. (2005) · Journal of Periodontology · doi:10.1902/jop.2005.76.12.2187 · Cited by 537
Association Between Chronic Periodontal Disease and Obesity: A Systematic Review and Meta‐Analysis
Chaffee, B. W., & Weston, S. J. (2010) · Journal of Periodontology · doi:10.1902/jop.2010.100321 · Cited by 524
Fan, X., Peters, B. A., Jacobs, E. J., Gapstur, S. M., Purdue, M. P., Freedman, N. D., Alekseyenko, A. V., Wu, J., Yang, L., Pei, Z., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0448-x · Cited by 240
“Large population-based studies have consistently demonstrated that alcohol consumption is associated with increased risk of periodontal disease in a dose-dependent fashion [24, 26].”
BackgroundInfluential
Metadata
- Authors
- Pitiphat, W., Merchant, A. T., Rimm, E. B., & Joshipura, K. J.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2003-07
- Volume
- 82
- Issue
- 7
- Pages
- 509-513
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2076305238
- Cited by
- 155
- References
- 30
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 13 · 2020: 10 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 8 · 2013: 8 · 2012: 7
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (AA-11181, R01AA011181)
- National Heart, Lung, and Blood Institute (R01HL035464, HL35464)
- National Cancer Institute (CA-55075)
- National Institute of Dental and Craniofacial Research (DE-12102, R01DE012102)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
- Keywords
- alcohol consumption, periodontitis, periodontal risk factors, modifiable risk factors, immune function, prospective cohort
- MeSH terms
- Adult, Aged, Alcohol Drinking, Humans, Male, Middle Aged, Periodontitis, Prospective Studies, Surveys and Questionnaires, Risk, Risk Factors, Smoking, Logistic Models, Proportional Hazards Models
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