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The Dentin Matrix Protein 1 (Dmp1) is Specifically Expressed in Mineralized, but not Soft, Tissues during Development
Abstract
Dentin Matrix Protein 1 ( Dmp1) was originally identified from dentin. However, its expression and function in vivo are not clear. To clarify these two issues, we have generated mice carrying a truncated Dmp1 gene by using gene targeting to replace exon 6 with a lacZ gene. Northern blot analysis shows the expected 5.8-kb Dmp1-lacZ fusion transcript and loss of the wild-type 2.8-kb Dmp1 transcript, confirmed by a lack of immunostaining for the protein. Using heterozygous animals, we demonstrate that Dmp1 is specific for mineralized tissues. Not previously shown, Dmp1 is also expressed in pulp cells. Dmp1-deficient embryos and newborns display no apparent gross abnormal phenotype, although there are a modest expansion of the hypertrophic chondrocyte zone and a modest increase in the long bone diameter. This suggests that DMP1 is not essential for early mouse skeletal or dental development.
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Citations
Cited by
BIOMECHANICAL AND MOLECULAR REGULATION OF BONE REMODELING
Robling, A. G., Castillo, A. B., & Turner, C. H. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095721 · Cited by 1,343
Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S. I., Zhang, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1905 · Cited by 1,199
Self-citationThe Osteocyte: An Endocrine Cell … and More
Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042
Self-citationPhosphorylated Proteins and Control over Apatite Nucleation, Crystal Growth, and Inhibition
George, A., & Veis, A. (2008) · Chemical Reviews · doi:10.1021/cr0782729 · Cited by 745
Structure of periodontal tissues in health and disease*
Nanci, A., & Bosshardt, D. D. (2006) · Periodontology 2000 · doi:10.1111/j.1600-0757.2005.00141.x · Cited by 677
Metadata
- Authors
- Feng, J. Q., Huang, H., Lu, Y., Ye, L., Xie, Y., Tsutsui, T. W., Kunieda, T., Castranio, T., Scott, G., Bonewald, L. B., & Mishina, Y.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2003-10
- Volume
- 82
- Issue
- 10
- Pages
- 776-780
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2129904461
- Cited by
- 239
- References
- 0
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Feng, J. Q., Huang, H., Lu, Y., Ye, L., Xie, Y., Tsutsui, T. W., Kunieda, T., Castranio, T., Scott, G., Bonewald, L. B., & Mishina, Y. (2003). The Dentin Matrix Protein 1 (Dmp1) is Specifically Expressed in Mineralized, but not Soft, Tissues during Development. Journal of Dental Research. https://doi.org/10.1177/154405910308201003
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