BIOMECHANICAL AND MOLECULAR REGULATION OF BONE REMODELING

Robling, Alexander G.; Castillo, Alesha B.; Turner, Charles H.

doi:10.1146/annurev.bioeng.8.061505.095721

Cited by 1,343Bone Metabolism and DiseasesBone health and osteoporosis researchSpaceflight effects on biology

BIOMECHANICAL AND MOLECULAR REGULATION OF BONE REMODELING

Robling, Alexander G., Castillo, Alesha B., Turner, Charles H.·2006·Annual Review of Biomedical Engineering

DOI 10.1146/annurev.bioeng.8.061505.095721

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Abstract

Bone is a dynamic tissue that is constantly renewed. The cell populations that participate in this process—the osteoblasts and osteoclasts—are derived from different progenitor pools that are under distinct molecular control mechanisms. Together, these cells form temporary anatomical structures, called basic multicellular units, that execute bone remodeling. A number of stimuli affect bone turnover, including hormones, cytokines, and mechanical stimuli. All of these factors affect the amount and quality of the tissue produced. Mechanical loading is a particularly potent stimulus for bone cells, which improves bone strength and inhibits bone loss with age. Like other materials, bone accumulates damage from loading, but, unlike engineering materials, bone is capable of self-repair. The molecular mechanisms by which bone adapts to loading and repairs damage are starting to become clear. Many of these processes have implications for bone health, disease, and the feasibility of living in weightless environments (e.g., spaceflight).

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From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [3]

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Authors: Robling, A. G., Castillo, A. B., & Turner, C. H.
Affiliations: Indiana University Indianapolis (US)
ORCID: Robling, Alexander G.
Castillo, Alesha B.
Venue: Annual Review of Biomedical Engineering
Publisher: Annual Reviews
Published: 2006-08-01
Volume: 8
Issue: 1
Pages: 455-498
ISSN: 1523-9829 (ISSN-L)
1545-4274
DOI: 10.1146/annurev.bioeng.8.061505.095721
OpenAlex: W2103378167
Cited by: 1,343
References: 151
Citations by year: 2026: 72 · 2025: 64 · 2024: 68 · 2023: 67 · 2022: 63 · 2021: 55 · 2020: 98 · 2019: 68 · 2018: 90 · 2017: 80 · 2016: 55 · 2015: 68 · 2014: 54 · 2013: 86 · 2012: 79
FWCI: 2.92
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Physiology › Spaceflight effects on biology
Keywords: bone remodeling, osteoblasts, osteoclasts, basic multicellular unit, bone turnover, mechanical loading, bone adaptation, bone injuries, bone loss, bone health, bone disease, microgravity, spaceflight, hormones, cytokines
MeSH terms: Animals, Biomechanical Phenomena, Bone and Bones, Feedback, Humans, Models, Biological, Osteoblasts, Osteoclasts, Osteogenesis, Bone Density, Weight-Bearing, Bone Remodeling, Mechanotransduction, Cellular

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BIOMECHANICAL AND MOLECULAR REGULATION OF BONE REMODELING

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