The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Periodontitis and Systemic Inflammation: Control of the Local Infection is Associated with a Reduction in Serum Inflammatory Markers
Abstract
Severe periodontitis is associated with elevated inflammatory markers in otherwise healthy populations. However, the nature of this association has not been determined. Our aim was to assess whether the degree of response to periodontal therapy was associated with changes in serological markers of systemic inflammation. Ninety-four systemically healthy subjects with severe generalized periodontitis participated in a prospective six-month blind intervention trial. Periodontal parameters and inflammatory markers [C-reactive Protein (CRP) and Interleukin-6 (IL-6)] were evaluated prior to and 2 and 6 mos after delivery of standard non-surgical periodontal therapy. Six months after treatment, significant reductions in serum IL-6 (p < 0.001, median decrease 0.2 ng/L, 95% CI 0.1–0.4 ng/L) and CRP (p < 0.0001, median decrease 0.5 mg/L, 95% CI 0.4–0.7) were observed. Decreases in inflammatory markers were significant in subjects with above average clinical response to periodontal therapy after correction for possible confounders. Periodontitis may add to the systemic inflammatory burden of affected individuals.
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Cites
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Cited by
Treatment of periodontitis and endothelial function
Tonetti, M. S., D'Aiuto, F., Nibali, L., Donald, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A. D., Vallance, P., & Deanfield, J. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063186 · Cited by 1,326
Self-citationLockhart, P. B., Bolger, A. F., Papapanou, P. N., Osinbowale, O., Trevisan, M., Levison, M. E., Taubert, K. A., Newburger, J. W., Gornik, H. L., Gewitz, M. H., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31825719f3 · Cited by 1,038
A systematic review and meta‐analyses on C‐reactive protein in relation to periodontitis
Paraskevas, S., Huizinga, J. D., & Loos, B. G. (2008) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2007.01173.x · Cited by 757
Kebschull, M., Demmer, R. T., & Papapanou, P. N. (2010) · Journal of Dental Research · doi:10.1177/0022034510375281 · Cited by 429
D'Aiuto, F., Parkar, M., Nibali, L., Suvan, J., Lessem, J., & Tonetti, M. S. (2006) · American Heart Journal · doi:10.1016/j.ahj.2005.06.018 · Cited by 332
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Metadata
- Authors
- D’Aiuto, F., Parkar, M., Andreou, G., Suvan, J., Brett, P. M., Ready, D., & Tonetti, M. S.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2004-02
- Volume
- 83
- Issue
- 2
- Pages
- 156-160
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2108042204
- Cited by
- 746
- References
- 30
- FWCI
- 34.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- D’Aiuto, F., Parkar, M., Andreou, G., Suvan, J., Brett, P. M., Ready, D., & Tonetti, M. S. (2004). Periodontitis and Systemic Inflammation: Control of the Local Infection is Associated with a Reduction in Serum Inflammatory Markers. Journal of Dental Research. https://doi.org/10.1177/154405910408300214
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
