“ Gum Bug, Leave My Heart Alone !”—Epidemiologic and Mechanistic Evidence Linking Periodontal Infections and Atherosclerosis

Kebschull, M.; Demmer, R.T.; Papapanou, P.N.

doi:10.1177/0022034510375281

Cited by 429Oral microbiology and periodontitis researchDental Research and COVID-19Periodontal Regeneration and Treatments

“ Gum Bug, Leave My Heart Alone !”—Epidemiologic and Mechanistic Evidence Linking Periodontal Infections and Atherosclerosis

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Kebschull, M., Demmer, R.T., Papapanou, P.N.·2010·Journal of Dental Research

DOI 10.1177/0022034510375281PMC PMC3318075

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Abstract

Evidence from epidemiologic studies suggests that periodontal infections are independently associated with subclinical and clinical atherosclerotic vascular disease. Although the strength of the reported associations is modest, the consistency of the data across diverse populations and a variety of exposure and outcome variables suggests that the findings are not spurious or attributable only to the effects of confounders. Analysis of limited data from interventional studies suggests that periodontal treatment generally results in favorable effects on subclinical markers of atherosclerosis, although such analysis also indicates considerable heterogeneity in responses. Experimental mechanistic in vitro and in vivo studies have established the plausibility of a link between periodontal infections and atherogenesis, and have identified biological pathways by which these effects may be mediated. However, the utilized models are mostly mono-infections of host cells by a limited number of ‘model’ periodontal pathogens, and therefore may not adequately portray human periodontitis as a polymicrobial, biofilm-mediated disease. Future research must identify in vivo pathways in humans that may (i) lead to periodontitis-induced atherogenesis, or (ii) result in treatment-induced reduction of atherosclerosis risk. Data from these studies will be essential for determining whether periodontal interventions have a role in the primary or secondary prevention of atherosclerosis.

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Periodontitis is a source of low-grade chronic systemic inflammation via haematogenous dissemination of periodontal bacteria or spillover of inflammatory mediators, contributing to systemic inflammatory burden and increasing risk of chronic diseases like CVD.
“Periodontitis is a local inflammation and a source of low-grade chronic inflammation, which results from haematogenous dissemination of periodontal bacteria or spillover of inflammatory mediators from periodontal tissues to the bloodstream [4, 9], thus contributing to the systemic inflammatory burden, increasing the risk of several chronic diseases like CVD, type II diabetes mellitus (T2DM), renal”
From Effect of non-surgical periodontal therapy on risk markers of cardiovascular disease: a systematic review and meta-analysis (2024) · cites this paper as [9]
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Background

Porphyromonas gulae Has Virulence and Immunological Characteristics Similar to Those of the Human Periodontal Pathogen Porphyromonas gingivalis
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Authors: Kebschull, M., Demmer, R. T., & Papapanou, P. N.
Affiliations: University of Bonn (DE)
Columbia University (US)
Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, 630 W 168th Street, PH-7-E-110
Corresponding author: Papapanou, P.N.
ORCID: Kebschull, M.
Demmer, R.T.
Papapanou, P.N.
Venue: Journal of Dental Research
Publisher: SAGE Publications
Published: 2010-07-16
Volume: 89
Issue: 9
Pages: 879-902
ISSN: 0022-0345 (ISSN-L)
1544-0591
DOI: 10.1177/0022034510375281
PMC: PMC3318075
OpenAlex: W2095060158
Cited by: 429
References: 292
Citations by year: 2026: 8 · 2025: 25 · 2024: 27 · 2023: 27 · 2022: 26 · 2021: 35 · 2020: 26 · 2019: 24 · 2018: 28 · 2017: 28 · 2016: 21 · 2015: 30 · 2014: 30 · 2013: 40 · 2012: 26
FWCI: 4.75
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Dental Research (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Dental and Craniofacial Research (DE-015649, R01DE015649, K99DE018739, R00DE018739)
National Center for Research Resources (RR025158)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords: periodontal infection, periodontitis, atherosclerosis, atherogenesis, subclinical atherosclerosis, periodontal treatment, polymicrobial biofilms, periodontal pathogens, vascular risk
MeSH terms: Animals, Brain Ischemia, Coronary Disease, Disease Models, Animal, Endothelium, Vascular, Humans, Monocytes, Periodontitis, Platelet Aggregation, Smoking, Lipid Peroxidation, Autoimmunity, Confounding Factors, Epidemiologic, Effect Modifier, Epidemiologic, Bacteremia, Oxidative Stress, Stroke, Atherosclerosis, Toll-Like Receptors

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“ Gum Bug, Leave My Heart Alone !”—Epidemiologic and Mechanistic Evidence Linking Periodontal Infections and Atherosclerosis

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