The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Collagen Degradation by Host-derived Enzymes during Aging
Abstract
Incompletely infiltrated collagen fibrils in acid-etched dentin are susceptible to degradation. We hypothesize that degradation can occur in the absence of bacteria. Partially demineralized collagen matrices (DCMs) prepared from human dentin were stored in artificial saliva. Control specimens were stored in artificial saliva containing proteolytic enzyme inhibitors, or pure mineral oil. We retrieved them at 24 hrs, 90 and 250 days to examine the extent of degradation of DCM. In the 24-hour experimental and 90- and 250-day control specimens, we observed 5- to 6-μm-thick layers of DCM containing banded collagen fibrils. DCMs were almost completely destroyed in the 250-day experimental specimens, but not when incubated with enzyme inhibitors or mineral oil. Functional enzyme analysis of dentin powder revealed low levels of collagenolytic activity that was inhibited by protease inhibitors or 0.2% chlorhexidine. We hypothesize that collagen degradation occurred over time, via host-derived matrix metalloproteinases that are released slowly over time.
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Cites
Tjäderhane, L., Larjava, H., Sorsa, T., Uitto, V.-J., Larmas, M., & Salo, T. (1998) · Journal of Dental Research · doi:10.1177/00220345980770081001 · Cited by 672
Four-year Water Degradation of Total-etch Adhesives Bonded to Dentin
De Munck, J., Van Meerbeek, B., Yoshida, Y., Inoue, S., Vargas, M., Suzuki, K., Lambrechts, P., & Vanherle, G. (2003) · Journal of Dental Research · doi:10.1177/154405910308200212 · Cited by 652
In vivo Degradation of Resin-Dentin Bonds in Humans Over 1 to 3 Years
Hashimoto, M., Ohno, H., Kaga, M., Endo, K., Sano, H., & Oguchi, H. (2000) · Journal of Dental Research · doi:10.1177/00220345000790060601 · Cited by 651
Self-citationInhibition of the Activities of Matrix Metalloproteinases 2, 8, and 9 by Chlorhexidine
Gendron, R., Grenier, D., Sorsa, T., & Mayrand, D. (1999) · Clinical Diagnostic Laboratory Immunology · doi:10.1128/cdli.6.3.437-439.1999 · Cited by 540
Long-term Durability of Dentin Bonds Made with a Self-etching Primer, in vivo
Sano, H., Yoshikawa, T., Pereira, P. N. R., Kanemura, N., Morigamui, M., Tagami, J., & Pashley, D. H. (1999) · Journal of Dental Research · doi:10.1177/00220345990780041101 · Cited by 506
Self-citationHybridization Efficiency of the Adhesive/Dentin Interface with Wet Bonding
Wang, Y., & Spencer, P. (2003) · Journal of Dental Research · doi:10.1177/154405910308200213 · Cited by 374
Hierarchical structures in fibrillar collagens
Ottani, V, Martini, D., Franchi, M., Ruggeri, A., & Raspanti, M. (2002) · Micron · doi:10.1016/s0968-4328(02)00033-1 · Cited by 306
The matrix metalloproteinase gelatinase A in human dentine
Martin-De Las Heras, S., Valenzuela, A., & Overall, C. M. (2000) · Archives of Oral Biology · doi:10.1016/s0003-9969(00)00052-2 · Cited by 287
Lee, W., Aitken, S., Sodek, J., & McCulloch, C. A. G. (1995) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1995.tb01249.x · Cited by 281
The Localization of Matrix Metalloproteinase-20 (MMP-20, Enamelysin) in Mature Human Teeth
Sulkala, M., Larmas, M., Sorsa, T., Salo, T., & Tjäderhane, L. (2002) · Journal of Dental Research · doi:10.1177/154405910208100905 · Cited by 214
Cited by
Tjäderhane, L., Buzalaf, M. A. R., Carrilho, M., & Chaussain, C. (2015) · Caries Research · doi:10.1159/000363582 · Cited by 2,306
Limitations in bonding to dentin and experimental strategies to prevent bond degradation
Liu, Y., Tjäderhane, L., Breschi, L., Mazzoni, A., Li, N., Mao, J., Pashley, D. H., & Tay, F. R. (2011) · Journal of Dental Research · doi:10.1177/0022034510391799 · Cited by 665
Self-citationAdhesive/Dentin Interface: The Weak Link in the Composite Restoration
Spencer, P., Ye, Q., Park, J., Topp, E. M., Misra, A., Marangos, O., Wang, Y., Bohaty, B. S., Singh, V., Sene, F., et al. (2010) · Annals of Biomedical Engineering · doi:10.1007/s10439-010-9969-6 · Cited by 470
Matrix metalloproteinase-8 (MMP-8) is the major collagenase in human dentin
Sulkala, M., Tervahartiala, T., Sorsa, T., Larmas, M., Salo, T., & Tjäderhane, L. (2007) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2006.08.009 · Cited by 342
Zymographic Analysis and Characterization of MMP-2 and -9 Forms in Human Sound Dentin
Mazzoni, A., Mannello, F., Tay, F. R., Tonti, G. A. M., Papa, S., Mazzotti, G., Di Lenarda, R., Pashley, D. H., & Breschi, L. (2007) · Journal of Dental Research · doi:10.1177/154405910708600509 · Cited by 329
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Metadata
- Authors
- Pashley, D. H., Tay, F. R., Yiu, C., Hashimoto, M., Breschi, L., Carvalho, R. M., & Ito, S.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2004-03
- Volume
- 83
- Issue
- 3
- Pages
- 216-221
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2168373863
- Cited by
- 1,123
- References
- 19
- FWCI
- 36.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pashley, D. H., Tay, F. R., Yiu, C., Hashimoto, M., Breschi, L., Carvalho, R. M., & Ito, S. (2004). Collagen Degradation by Host-derived Enzymes during Aging. Journal of Dental Research. https://doi.org/10.1177/154405910408300306
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