The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Zymographic Analysis and Characterization of MMP-2 and -9 Forms in Human Sound Dentin
Abstract
The role and function of dentin matrix metalloproteinases (MMPs) are not well-understood, but they may play a key role in dentinal caries and the degradation of resin-bonded dentin matrices. To test the null hypothesis that MMP-9 is not found in dentin matrix, we used gelatin zymography to extract and isolate all molecular forms of gelatinolytic MMPs in demineralized mature sound dentin powder obtained from extracted human molars, characterizing and identifying the enzymes by Western blotting. Gelatinolytic MMPs were detected in extracts of demineralized dentin matrix and identified as MMP-2 and MMP-9. Acidic extracts (pH 2.3) yielded 3–8 times more MMP activity than did EDTA (pH 7.4). Their activation may contribute to dentin matrix degradation, which occurs during caries progression and following resin bonding. Inhibition of MMP-2 and -9 proteolytic activity may slow caries progression and increase the durability of resin-dentin bonds.
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Citations
Cites
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
Visse, R., & Nagase, H. (2003) · Circulation Research · doi:10.1161/01.res.0000070112.80711.3d · Cited by 4,575
Collagen Degradation by Host-derived Enzymes during Aging
Pashley, D. H., Tay, F. R., Yiu, C., Hashimoto, M., Breschi, L., Carvalho, R. M., & Ito, S. (2004) · Journal of Dental Research · doi:10.1177/154405910408300306 · Cited by 1,123
Self-citationBiochemistry and Molecular Biology of Gelatinase B or Matrix Metalloproteinase-9 (MMP-9)
Van den Steen, P. E., Dubois, B., Nelissen, I., Rudd, P. M., Dwek, R. A., & Opdenakker, G. (2002) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230290771546 · Cited by 946
The dentin substrate: structure and properties related to bonding
Marshall, G. W., Marshall, S. J., Kinney, J. H., & Balooch, M. (1997) · Journal of Dentistry · doi:10.1016/s0300-5712(96)00065-6 · Cited by 886
Tjäderhane, L., Larjava, H., Sorsa, T., Uitto, V.-J., Larmas, M., & Salo, T. (1998) · Journal of Dental Research · doi:10.1177/00220345980770081001 · Cited by 672
Chlorhexidine Arrests Subclinical Degradation of Dentin Hybrid Layers in vivo
Hebling, J., Pashley, D. H., Tjäderhane, L., & Tay, F. R. (2005) · Journal of Dental Research · doi:10.1177/154405910508400811 · Cited by 537
Self-citationGoldberg, M., & Smith, A. J. (2004) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130401500103 · Cited by 535
The role of matrix metalloproteinases (MMPs) in human caries
Chaussain-Miller, C., Fioretti, F., Goldberg, M., & Menashi, S. (2006) · Journal of Dental Research · doi:10.1177/154405910608500104 · Cited by 481
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Cited by
Tjäderhane, L., Buzalaf, M. A. R., Carrilho, M., & Chaussain, C. (2015) · Caries Research · doi:10.1159/000363582 · Cited by 2,306
Limitations in bonding to dentin and experimental strategies to prevent bond degradation
Liu, Y., Tjäderhane, L., Breschi, L., Mazzoni, A., Li, N., Mao, J., Pashley, D. H., & Tay, F. R. (2011) · Journal of Dental Research · doi:10.1177/0022034510391799 · Cited by 665
Self-citationRole of dentin MMPs in caries progression and bond stability
Mazzoni, A., Tjäderhane, L., Checchi, V., Di Lenarda, R., Salo, T., Tay, F. R., Pashley, D. H., & Breschi, L. (2015) · Journal of Dental Research · doi:10.1177/0022034514562833 · Cited by 429
Self-citationCan quaternary ammonium methacrylates inhibit matrix MMPs and cathepsins
Tezvergil-Mutluay, A., Agee, K. A., Mazzoni, A., Carvalho, R. M., Carrilho, M., Tersariol, I. L., Nascimento, F. D., Imazato, S., Tjäderhane, L., Breschi, L., et al. (2015) · Dental Materials · doi:10.1016/j.dental.2014.10.006 · Cited by 73
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Metadata
- Authors
- Mazzoni, A., Mannello, F., Tay, F. R., Tonti, G. A. M., Papa, S., Mazzotti, G., Di Lenarda, R., Pashley, D. H., & Breschi, L.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2007-05
- Volume
- 86
- Issue
- 5
- Pages
- 436-440
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W1993281392
- Cited by
- 329
- References
- 28
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mazzoni, A., Mannello, F., Tay, F. R., Tonti, G. A. M., Papa, S., Mazzotti, G., Di Lenarda, R., Pashley, D. H., & Breschi, L. (2007). Zymographic Analysis and Characterization of MMP-2 and -9 Forms in Human Sound Dentin. Journal of Dental Research. https://doi.org/10.1177/154405910708600509
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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