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Expression of SIBLINGs and Their Partner MMPs in Salivary Glands
Abstract
Three members of the SIBLING family of integrin-binding phosphoglycoproteins (bone sialoprotein, BSP; osteopontin, OPN; and dentin matrix protein-1, DMP1) were recently shown to bind with high affinity (nM) and to activate 3 different matrix metalloproteinases (MMP-2, MMP-3, and MMP-9, respectively) in vitro. The current study was designed to document the possible biological relevance of the SIBLING-MMP activation pathway in vivo by showing that these 3 SIBLINGs and their known MMP partners are co-expressed in normal adult tissue. BSP, OPN, and DMP1 were invariably co-expressed with their partner MMPs in salivary glands of humans and mice. The 2 SIBLING proteins without known MMP partners, dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE), were also expressed in salivary glands. Expression of all SIBLINGs in this normal, non-mineralizing epithelial tissue suggests that they serve at least one function in vivo other than directly promoting matrix mineralization—a function we hypothesize involves local activation of MMPs.
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Cited by
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Martin, A., David, V., & Quarles, L. D. (2012) · Physiological Reviews · doi:10.1152/physrev.00002.2011 · Cited by 594
The role of matrix metalloproteinases (MMPs) in human caries
Chaussain-Miller, C., Fioretti, F., Goldberg, M., & Menashi, S. (2006) · Journal of Dental Research · doi:10.1177/154405910608500104 · Cited by 481
Endocrine functions of bone in mineral metabolism regulation
Quarles, L. D. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36479 · Cited by 459
DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis
Ling, Y., Rios, H. F., Myers, E. R., Lu, Y., Feng, J. Q., & Boskey, A. L. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050815 · Cited by 216
Metadata
- Authors
- Ogbureke, K. U. E., & Fisher, L. W.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2004-09
- Volume
- 83
- Issue
- 9
- Pages
- 664-670
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2127592468
- Cited by
- 177
- References
- 0
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ogbureke, K. U. E., & Fisher, L. W. (2004). Expression of SIBLINGs and Their Partner MMPs in Salivary Glands. Journal of Dental Research. https://doi.org/10.1177/154405910408300902
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