Cited by 334Oral microbiology and periodontitis researchPsoriasis: Treatment and PathogenesisPeriodontal Regeneration and Treatments

The DOI matches its Crossref record; 171 of the 171 references it cites were found in a registry or an index.

A New Inflammatory Cytokine on the Block: Re-thinking Periodontal Disease and the Th1/Th2 Paradigm in the Context of Th17 Cells and IL-17

Open access

Gaffen, S.L., Hajishengallis, G.·2008·Journal of Dental Research

DOI 10.1177/154405910808700908PMC PMC2692983

Open this paper in CoChat — free account

Abstract

For almost two decades, the Th1/Th2 paradigm has offered a productive conceptual framework for investigating the pathogenesis of periodontitis. However, as with many other inflammatory diseases, the observed role of T-cell-mediated immunity in periodontitis did not readily fit this model. A new subset of CD4+ T-cells was recently discovered that explains many of the discrepancies in the classic Th1/Th2 model, and has been termed “Th17” based on its secretion of the novel pro-inflammatory cytokine IL-17. The identification of Th17 cells as a novel effector T-cell population compels re-examination of periodontitis in the context of the new subset and its signature cytokines. This review aims to offer a clarifying insight into periodontal pathogenesis under the extended Th1/Th2/Th17 paradigm, and is predicated on the principle that periodontal disease activity is determined by a complex interplay between the immune system and periodontal pathogens. The re-examination of existing periodontal literature and further studies in the light of these new discoveries may help explain how the inflammatory response results in damage to the periodontium while generally failing to control the pathogens. This knowledge is essential for the development of immunomodulatory intervention strategies for fine-tuning the host response to maximize the protective and minimize the destructive aspects of the periodontal host response. Moreover, with the advent of anti-cytokine biologic drugs that target the Th1 and Th17 pathways in autoimmunity, the potential consequences to periodontal disease susceptibility in humans need to be understood.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1177/154405910808700908

Cites

171 of 171 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,553
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
Toll-like receptor control of the adaptive immune responses
Iwasaki, A., & Medzhitov, R. M. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,166
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
Periodontal diseases
Pihlstrom, B. L., Michalowicz, B. S., & Johnson, N. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67728-8 · Cited by 3,718
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087

Show all 171 references

Sorted by citations

Items 101–200 of 334

Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg–Th17 Plasticity in Periodontitis
Rajendran, M., Looney, S. W., Singh, N., Elashiry, M., Meghil, M. M., El‐Awady, A., Tawfik, O. K., Susin, C., Arce, R. M., & Cutler, C. W. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900046 · Cited by 63
Association study between salivary levels of interferon (IFN)-gamma, interleukin (IL)-17, IL-21, and IL-22 with chronic periodontitis
Isaza‐Guzmán, D. M., Cardona-Vélez, N., Gaviria-Correa, D. E., Pabón, M. C. M., Castaño-Granada, M. C., & Tobón‐Arroyave, S. I. (2014) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2014.09.002 · Cited by 58
Periodontal Regeneration by Allogeneic Transplantation of Adipose Tissue Derived Multi-Lineage Progenitor Stem Cells in vivo
Venkataiah, V. S., Handa, K., Njuguna, M. M., Hasegawa, T., Maruyama, K., Nemoto, E., Yamada, S., Sugawara, S., Lu, L., Takedachi, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-37528-0 · Cited by 58
The osteoimmunology of alveolar bone loss
Tompkins, K. A. (2016) · Connective Tissue Research · doi:10.3109/03008207.2016.1140152 · Cited by 57
Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction
Tan, J., Dai, A., Pan, L., Zhang, L., Wang, Z., Ke, T., Sun, W., Wu, Y., Ding, P., & Chen, L. (2021) · Journal of Immunology Research · doi:10.1155/2021/9919024 · Cited by 56
IL ‐17 stimulates the production of the inflammatory chemokines IL ‐6 and IL ‐8 in human dental pulp fibroblasts
Xiong, H., Wei, L., & Peng, B. (2014) · International Endodontic Journal · doi:10.1111/iej.12339 · Cited by 55
A Controversial Role for IL‐12 in Immune Response and Bone Resorption at Apical Periodontal Sites
Queiroz‐Junior, C. M., Silva, M. J. B., Corrêa, J. D., Madeira, M. F. M., Garlet, T. P., Garlet, G. P., Cunha, F. Q., Teixeira, M. M., & Silva, T. A. (2010) · Journal of Immunology Research · doi:10.1155/2010/327417 · Cited by 55
A Systematic Review and Meta-Analysis on Multiple Cytokine Gene Polymorphisms in the Pathogenesis of Periodontitis
Liu, X. Z., & Li, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.713198 · Cited by 54
TLR2 Signaling and Th2 Responses Drive Tannerella forsythia-Induced Periodontal Bone Loss
Myneni, S. R., Settem, R. P., Connell, T. D., Keegan, A. D., Gaffen, S. L., & Sharma, A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100683 · Cited by 56
Self-citation
Heat-Labile Enterotoxins as Adjuvants or Anti-Inflammatory Agents
Liang, S., & Hajishengallis, G. (2010) · Immunological Investigations · doi:10.3109/08820130903563998 · Cited by 54
Self-citation
Porphyromonas gingivalis lipopolysaccharides regulate functions of bone marrow mesenchymal stem cells
Tang, J., Wu, T., Xiong, J., Su, Y., Zhang, C., Wang, S., Tang, Z., & Liu, Y. (2015) · Cell Proliferation · doi:10.1111/cpr.12173 · Cited by 54
Shared microbiological and immunological patterns in periodontitis and IBD: A scoping review
Baima, G., Massano, A., Squillace, E., Caviglia, G. P., Buduneli, N., Ribaldone, D. G., & Aimetti, M. (2021) · Oral Diseases · doi:10.1111/odi.13843 · Cited by 55
Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response
Hatasa, M., Yoshida, S., Takahashi, H., Tanaka, K., Kubotsu, Y., Ohsugi, Y., Katagiri, T., Iwata, T., & Katagiri, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073728 · Cited by 57
Association between Polymorphisms in Interleukin-17A and -17F Genes and Chronic Periodontal Disease
Corrêa, J. D., Madeira, M. F. M., Resende, R. G., Correia‐Silva, J. D. F., Gomez, R. S., de Souza, D. D. G., Teixeira, M. M., Queiroz‐Junior, C. M., & Silva, T. A. (2012) · Mediators of Inflammation · doi:10.1155/2012/846052 · Cited by 55
Interaction Between Oral Lichen Planus and Chronic Periodontitis with Th17-Associated Cytokines in Serum
Wang, H., Luo, Z., Lei, L., Sun, Z., Zhou, M., Dan, H., Zeng, X. Y., & Chen, Q. (2013) · Inflammation · doi:10.1007/s10753-013-9594-2 · Cited by 53
Transcriptome sequencing of gingival biopsies from chronic periodontitis patients reveals novel gene expression and splicing patterns
Kim, Y., Kim, M.-J., Kang, J. H., Kim, H. J., Park, J.-W., Lee, J., Suh, J., Kim, J., Lee, J., & Lee, Y. (2016) · Human Genomics · doi:10.1186/s40246-016-0084-0 · Cited by 55
Association of the invasion ability of Porphyromonas gingivalis with the severity of periodontitis
Baek, K. J., Ji, S., Kim, Y. C., & Choi, Y. (2015) · Virulence · doi:10.1080/21505594.2014.1000764 · Cited by 51
General Immune Status and Oral Microbiology in Patients with Different Forms of Periodontitis and Healthy Control Subjects
Schmidt, J., Jentsch, H. F. R., Stîngu, C.-S., & Sack, U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109187 · Cited by 50
Association of a genetic polymorphism (-44 C/G SNP) in the human DEFB1 gene with expression and inducibility of multiple β-defensins in gingival keratinocytes
Kalus, A., Fredericks, L. P., Hacker, B. M., Dommisch, H., Presland, R. B., Kimball, J. R., & Dale, B. A. (2009) · BMC Oral Health · doi:10.1186/1472-6831-9-21 · Cited by 50
Increased levels of the T‐helper 22‐associated cytokine (interleukin‐22) and transcription factor (aryl hydrocarbon receptor) in patients with periodontitis are associated with osteoclast resorptive activity and severity of the disease
Díaz-Zúñiga, J. A., Melgar-Rodríguez, S. A., Rojas, L., Álvarez, C., Monasterio, G., Carvajal, P., & Vernal, R. (2017) · Journal of Periodontal Research · doi:10.1111/jre.12461 · Cited by 48
Immune‐mediated diseases: what can be found in the oral cavity?
Martínez, A. B., García‐García, V., Meurman, J. H., & Requena‐Caballero, L. (2014) · International Journal of Dermatology · doi:10.1111/ijd.12681 · Cited by 46
Pathogenic Microbes and Community Service Through Manipulation of Innate Immunity
Hajishengallis, G., Krauss, J. L., Liang, S., McIntosh, M. L., & Lambris, J. D. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0106-3_5 · Cited by 47
Self-citation
IL ‐22–expressing CD 4+AhR+ T lymphocytes are associated with RANKL ‐mediated alveolar bone resorption during experimental periodontitis
Monasterio, G., Budini, V., Fernández, B., Castillo, F. A., Rojas, C., Álvarez, C., Cafferata, E. A., Vicencio, E., Cortés, B. I., Cortéz, C., et al. (2019) · Journal of Periodontal Research · doi:10.1111/jre.12654 · Cited by 45
Inflammatory and Immunological Basis of Periodontal Diseases
Baima, G., Arce, M., Romandini, M., & Dyke, T. E. V. (2025) · Journal of Periodontal Research · doi:10.1111/jre.70040 · Cited by 53
Sequential IL‐23 and IL‐17 and increased Mmp8 and Mmp14 expression characterize the progression of an experimental model of periodontal disease in type 1 diabetes
Silva, J. A. F., Ferrucci, D. L., Peroni, L. A., Abrahão, P. G. S., Salamene, A. F., Rossa, C., Carvalho, H. F., & Stach‐Machado, D. R. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22979 · Cited by 44
Effects of Edible Treats Containing Ascophyllum nodosum on the Oral Health of Dogs: A Double-Blind, Randomized, Placebo-Controlled Single-Center Study
Gawor, J. P., Jank, M., Jodkowska, K., Klim, E. B., & Svensson, U. (2018) · Frontiers in Veterinary Science · doi:10.3389/fvets.2018.00168 · Cited by 42
Association of interleukin‐10 gene promoter polymorphisms with chronic and aggressive periodontitis
Jaradat, S., Ababneh, K. T., Jaradat, S. A., Abbadi, M., Taha, A., Karasneh, J., & Haddad, H. I. (2011) · Oral Diseases · doi:10.1111/j.1601-0825.2011.01872.x · Cited by 42
Dental Caries and Head and Neck Cancers
Tezal, M., Scannapieco, F. A., Wactawski‐Wende, J., Meurman, J. H., Marshall, J. R., Rojas, I. G., Stoler, D. L., & Genco, R. J. (2013) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2013.4569 · Cited by 42
Neutrophil Dysfunction and Host Susceptibility to Periodontal Inflammation: Current State of Knowledge
Sima, C., & Glogauer, M. (2014) · Current Oral Health Reports · doi:10.1007/s40496-014-0015-x · Cited by 44
Calcitriol Suppressed Inflammatory Reactions in IL-1β-Stimulated Human Periodontal Ligament Cells
Hosokawa, Y., Hosokawa, I., Shindo, S., Ozaki, K., & Matsuo, T. (2015) · Inflammation · doi:10.1007/s10753-015-0209-y · Cited by 41
Up‐regulation of IL ‐23 expression in human dental pulp fibroblasts by IL ‐17 via activation of the NF ‐κB and MAPK pathways
Wei, L., Liu, M., Xiong, H., & Peng, B. (2017) · International Endodontic Journal · doi:10.1111/iej.12871 · Cited by 39
Etiology of leukocyte adhesion deficiency-associated periodontitis revisited: not a raging infection but a raging inflammatory response
Hajishengallis, G., & Moutsopoulos, N. M. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.929944 · Cited by 38
Self-citation
The Immune Response in Periodontal Tissues
Nędzi-Góra, M., Kowalski, J., & Górska, R. (2017) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-017-0472-8 · Cited by 38
Anti-inflammatory effects of EMD in the presence of biomechanical loading and interleukin-1β in vitro
Nokhbehsaim, M., Rath-Deschner, B., Winter, J., Bourauel, C. P., Jäger, A., Jepsen, S. V., & Deschner, J. (2011) · Clinical Oral Investigations · doi:10.1007/s00784-010-0505-8 · Cited by 38
Immunology of Diseases of the Oral Cavity
Challacombe, S., Shirlaw, P., & Thornhill, M. H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-415847-4.00102-6 · Cited by 40
Cytokine Networks Regulating Inflammation and Immune Defense in the Oral Cavity
Cavalla, F., Araujo‐Pires, A. C., Biguetti, C. C., & Garlet, G. P. (2014) · Current Oral Health Reports · doi:10.1007/s40496-014-0016-9 · Cited by 37
Toll gates to periodontal host modulation and vaccine therapy
Hajishengallis, G. (2009) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00304.x · Cited by 38
Self-citation
Calcitriol suppresses lipopolysaccharide‐induced alveolar bone damage in rats by regulating T helper cell subset polarization
Bi, C., Wang, J., Qu, H., Li, X., Tian, B., Ge, S., & Chen, F. (2019) · Journal of Periodontal Research · doi:10.1111/jre.12661 · Cited by 37
Targeting epigenetic mechanisms in periodontal diseases
Barros, S. P., Hefni, E., Nepomuceno, R., Offenbacher, S., & North, K. E. (2018) · Periodontology 2000 · doi:10.1111/prd.12231 · Cited by 44
Effect of interleukin (IL)-35 on IL-17 expression and production by human CD4 + T cells
Okada, K., Fujimura, T., Kikuchi, T., Aino, M., Kamiya, Y., Izawa, A., Iwamura, Y., Goto, H., Okabe, I., Miyake, E., et al. (2017) · PeerJ · doi:10.7717/peerj.2999 · Cited by 36
Inactive Gingipains from P. gingivalis Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent Manner
Główczyk, I., Wong, A., Potempa, B. A., Babyak, O., Lech, M., Lamont, R. J., Potempa, J., & Kozieł, J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00140 · Cited by 37
Periodontal Disease-Associated Compensatory Expression of Osteoprotegerin Is Lost in Type 1 Diabetes Mellitus and Correlates with Alveolar Bone Destruction by Regulating Osteoclastogenesis
Silva, J. A. F., Ferrucci, D. L., Peroni, L. A., Ishi, E. D. P., Rossa, C., Carvalho, H. F., & Stach‐Machado, D. R. (2012) · Cells Tissues Organs · doi:10.1159/000330879 · Cited by 35
TREM-1 Is Upregulated in Experimental Periodontitis, and Its Blockade Inhibits IL-17A and RANKL Expression and Suppresses Bone loss
Bostancı, N., Abe, T., Belibasakis, G. N., & Hajishengallis, G. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101579 · Cited by 35
Self-citation
Regulation of osteoclastogenesis through Tim-3: possible involvement of the Tim-3/galectin-9 system in the modulation of inflammatory bone destruction
Moriyama, K., Kukita, A., Li, Y.-J., Uehara, N., Zhang, J.-Q., Takahashi, I., & Kukita, T. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.107 · Cited by 35
Inflammatory reaction – communication of cells
Terheyden, H., Stadlinger, B., Sanz, M., Garbe, A. I., & Meyle, J. (2013) · Clinical Oral Implants Research · doi:10.1111/clr.12176 · Cited by 36
Activity of inflammatory bowel disease influences the expression of cytokines in gingival tissue
Figueredo, C. M., Martins, A. P., Lira-Junior, R., Menegat, J. S. B., Carvalho, A. T. P., Fischer, R. G., & Gustafsson, A. K. (2017) · Cytokine · doi:10.1016/j.cyto.2017.01.016 · Cited by 34
Interleukin-17 and interleukin-23 levels in gingival crevicular fluid of patients with chronic and aggressive periodontitis
Sadeghi, R., Sattari, M., Dehghan, F., & Akbari, S. (2018) · Central European Journal of Immunology · doi:10.5114/ceji.2018.74876 · Cited by 34
Monodisperse and LPS-free Aggregatibacter actinomycetemcomitans leukotoxin: Interactions with human β2 integrins and erythrocytes
Reinholdt, J., Poulsen, K., Brinkmann, C. R., Hoffmann, S. V., Stapulionis, R., Enghild, J. J., Jensen, U. B., Boesen, T. P., & Vorup‐Jensen, T. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2012.12.004 · Cited by 34
Pathogenesis‐Guided Engineering of Multi‐Bioactive Hydrogel Co‐Delivering Inflammation‐Resolving Nanotherapy and Pro‐Osteogenic Protein for Bone Regeneration
Liu, S., Wang, W., Wu, P., Chen, Z., Pu, W., Li, L., Li, G., Zhang, J., & Song, J. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202301523 · Cited by 33
The positive effects of secreting cytokines IL-17 and IFN-γ on the early-stage differentiation and negative effects on the calcification of primary osteoblasts in vitro
Wang, Z., Tan, J., Lei, L., Sun, W., Wu, Y., Ding, P., & Chen, L. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.02.002 · Cited by 47
Sea Buckthorn Polysaccharide Ameliorates Colitis
Ouyang, Q., Li, X., Liang, Y., & Liu, R. (2024) · Nutrients · doi:10.3390/nu16091280 · Cited by 32
Mucosal Vaccination Against Periodontal Disease: Current Status and Opportunities
Vaernewyck, V., Arzi, B., Sanders, N. N., Cox, E., & Devriendt, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.768397 · Cited by 32
Fine-tuning of Th17 Cytokines in Periodontal Disease by IL-10
Moretti, S., Bartolommei, L., Galosi, C., Renga, G., Oikonomou, V., Zamparini, F., Ricci, G., Borghi, M., Puccetti, M., Piobbico, D., et al. (2015) · Journal of Dental Research · doi:10.1177/0022034515591790 · Cited by 31
Cell biology of osteoimmunology
Gruber, R. (2010) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-010-0809-y · Cited by 31
S‐Nitrosoglutathione Decreases Inflammation and Bone Resorption in Experimental Periodontitis in Rats
de Menezes, A. M. A., de Souza, G. F. P., Gomes, A. S., Leitão, R. F. D. C., Ribeiro, R. D. A., de Oliveira, M. G., & Brito, G. A. D. C. (2011) · Journal of Periodontology · doi:10.1902/jop.2011.110332 · Cited by 30
Two Cheers for Crohn's Disease and Periodontitis: Beta-Defensin-2 as an Actionable Target to Intervene on Two Clinically Distinct Diseases
Keskin, M., Zeidán‐Chuliá, F., Gürsoy, M., Könönen, E., Rautava, J., & Gürsoy, U. K. (2015) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2015.0077 · Cited by 29
Porphyromonas gingivalis oral infection promote T helper 17/Treg imbalance in the development of atherosclerosis
Yang, J., Wu, J., Zhang, R., Yao, M., Liu, Y., Miao, L., & Sun, W. (2016) · Journal of Dental Sciences · doi:10.1016/j.jds.2016.10.003 · Cited by 29
Gingival crevicular fluid and interleukin‐23 concentration in systemically healthy subjects: their relationship in periodontal health and disease
Himani, G. S., Prabhuji, M. L. V., & Karthikeyan, B. V. (2013) · Journal of Periodontal Research · doi:10.1111/jre.12100 · Cited by 29
Oral lichen planus may enhance the expression of Th17-associated cytokines in local lesions of chronic periodontitis
Wang, H., Han, Q., Luo, Z., Xu, C.-X., Liu, J., Dan, H., Xu, Y., Zeng, X. Y., & Chen, Q. (2013) · Clinical Oral Investigations · doi:10.1007/s00784-013-1131-z · Cited by 29
Distinct human T‐lymphocyte responses triggered by Porphyromonas gingivalis capsular serotypes
Vernal, R., Diaz‐Guerra, E., Silva, A., Sanz, M., & Garcia‐Sanz, J. A. (2014) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12176 · Cited by 29
Interleukin‐17A Stimulates Migration of Periodontal Ligament Fibroblasts Via p38 MAPK/NF‐κB ‐Dependent MMP‐1 Expression
Wu, Y. R., Zhu, L., Liu, L., Zhang, J., & Peng, B. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24444 · Cited by 29
mTOR Signaling in the Regulation of CD4+ T Cell Subsets in Periodontal Diseases
Jiang, Q., Huang, X., Yu, W., Huang, R., Zhao, X., & Chen, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.827461 · Cited by 28
Porphyromonas gingivalis Induces RANKL in T-cells
Belibasakis, G. N., Reddi, D., & Bostancı, N. (2010) · Inflammation · doi:10.1007/s10753-010-9216-1 · Cited by 28
T-helper cells in the etiopathogenesis of periodontal disease: A mini review
Talwar, A., Arun, K., & Kumar, T. S. S. (2011) · Journal of Indian Society of Periodontology · doi:10.4103/0972-124x.82255 · Cited by 27
Cellular Mechanisms of Inflammaging and Periodontal Disease
Clark, D. L., Radaic, A., & Kapila, Y. L. (2022) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2022.844865 · Cited by 28
Porphyromonas gingivalis-derived RgpA-Kgp Complex Activates the Macrophage Urokinase Plasminogen Activator System
Fleetwood, A. J., O’brien-simpson, N. M., Veith, P. D., Lam, R. S., Achuthan, A. A., Cook, A. D., Singleton, W., Lund, I. K., Reynolds, E. C., & Hamilton, J. A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.645572 · Cited by 26
Fusobacterium nucleatum regulation of neutrophil transcription
Wright, H. J., Chapple, I., Matthews, J. B., & Cooper, P. R. (2010) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2010.01299.x · Cited by 26
Role of indoleamine 2,3‐dioxygenase in an inflammatory model of murine gingiva
Qin, X., Liu, J. Y., Wang, T., Pashley, D. H., Alhashim, A., Abdelsayed, R. A., Yu, J., Mozaffari, M. S., & Baban, B. (2016) · Journal of Periodontal Research · doi:10.1111/jre.12374 · Cited by 25
Shikonin Inhibits Inflammatory Cytokine Production in Human Periodontal Ligament Cells
Shindo, S., Hosokawa, Y., Hosokawa, I., Ozaki, K., & Matsuo, T. (2016) · Inflammation · doi:10.1007/s10753-016-0344-0 · Cited by 25
Calcitriol inhibits osteoclastogenesis in an inflammatory environment by changing the proportion and function of T helper cell subsets (Th2/Th17)
Bi, C., Li, X., Qu, H., Sun, L., An, Y., Hong, Y., Tian, B., & Chen, F. (2020) · Cell Proliferation · doi:10.1111/cpr.12827 · Cited by 25
Differential expression of pro-inflammatory and anti-inflammatory cytokines during experimental infection with low or high virulence bovine viral diarrhea virus in beef calves
Palomares, R. A., Brock, K. V., & Walz, P. H. (2013) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2013.12.002 · Cited by 25
Salivary citrullinated proteins in rheumatoid arthritis and associated periodontal disease
Tar, I., Csősz, É., Végh, E., Lundberg, K., Kharlamova, N., Soós, B., Szekanecz, Z., & Márton, I. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-93008-y · Cited by 24
Correlation of chronic periodontitis in tropical area and IFN-γ, IL-10, IL-17 levels
Fu, Q., Zhang, L., Duan, L., Qian, S., & Pang, H. (2013) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(13)60080-2 · Cited by 24
Correlation of salivary cytokine IL-17A and 1,25 dihydroxycholecalciferol in patients undergoing orthodontic treatment
Sagar, S., Ramani, P., Moses, S., Gheena, S., & Jayaraman, S. (2024) · Odontology · doi:10.1007/s10266-023-00890-1 · Cited by 25
Does oral lichen planus aggravate the state of periodontal disease? A systematic review and meta-analysis
Nunes, G. P., Pirovani, B. O., Nunes, L. P., Silva, A. N. A., Morábito, M. J. S. D., Nunes, N. A., Delbem, A. C. B., & Ferrisse, T. M. (2022) · Clinical Oral Investigations · doi:10.1007/s00784-022-04387-z · Cited by 23
Regulation of Matrix Metalloproteinases, Tissue Inhibitor of Matrix Metalloproteinase-1, and Extracellular Metalloproteinase Inducer by Interleukin-17 in Human Periodontal Ligament Fibroblasts
Wu, Y. R., Zhu, L., Wei, H., & Peng, B. (2012) · Journal of Endodontics · doi:10.1016/j.joen.2012.09.025 · Cited by 22
Clinical Significance of IL-23 Regulating IL-17A and/or IL-17F Positive Th17 Cells in Chronic Periodontitis
Luo, Z., Wang, H., Wu, Y., Sun, Z., & Wu, Y. (2014) · Mediators of Inflammation · doi:10.1155/2014/627959 · Cited by 23
Age‐related alterations in gene expression of gingival fibroblasts stimulated with P orphyromonas gingivalis
Domon, H., Tabeta, K., Nakajima, T. E., & Yamazaki, K. (2013) · Journal of Periodontal Research · doi:10.1111/jre.12134 · Cited by 22
A Systematic Review of Interleukin-17 in Oral Lichen Planus: From Etiopathogenesis to Treatment
Agha‐Hosseini, F., Moosavi, M., & Bahrami, H. (2023) · Clinical Medicine & Research · doi:10.3121/cmr.2023.1822 · Cited by 25
Comparative Evaluation of IFNγ, IL4 and IL17 Cytokines in Healthy Gingiva and Moderate to Advanced Chronic Periodontitis.
Behfarnia, P., Birang, R., Andalib, A. R., & Asadi, S. (2010) · Europe PMC (PubMed Central) · Cited by 21
Isolation of T cells from mouse oral tissues
Pandiyan, P., Bhaskaran, N., Zhang, Y., & Weinberg, A. (2014) · Biological Procedures Online · doi:10.1186/1480-9222-16-4 · Cited by 22
Analysis of Interleukin 17A in periapical abscess and granuloma lesions
Ferreira, L. G. V., Rosin, F. C. P., & Côrrea, L. (2016) · Brazilian Oral Research · doi:10.1590/1807-3107bor-2016.vol30.0034 · Cited by 21
Expression levels of th-2 and th-17 characteristic genes in healthy tissue versus periodontitis.
Behfarnia, P., Birang, R., Pishva, S. S., Ganjalıkhani-Hakemi, M., & Khorasani, M. M. (2013) · Europe PMC (PubMed Central) · Cited by 20
Complement-Targeted Therapeutics in Periodontitis
Hajishengallis, G., & Lambris, J. D. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4118-2_13 · Cited by 20
Self-citation
Natural T Regulatory Cells (n Treg) in the Peripheral Blood of Healthy Subjects and Subjects with Chronic Periodontitis – A Pilot Study
Sabarish, R. (2016) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2016/15449.7446 · Cited by 20
Inflammatory markers in saliva as indicators of gingival inflammation in cerebral palsy children with and without cervical motor control
Santos, M. T. B. R., Diniz, M. B., Guaré, R. D. O., Ferreira, M. C. D., de Gutierrez, G. M., & Gorjão, R. (2016) · International Journal of Paediatric Dentistry · doi:10.1111/ipd.12270 · Cited by 20
Differential human Th22-lymphocyte response triggered by Aggregatibacter actinomycetemcomitans serotypes
Díaz-Zúñiga, J. A., Melgar-Rodríguez, S. A., Monasterio, G., Pujol, M., Rojas, L., Álvarez, C., Carvajal, P., & Vernal, R. (2017) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2017.02.008 · Cited by 20
Soft tissue surrounding switched platform implants: an immunohistochemical evaluation
Dellavia, C. P. B., Canullo, L., Allievi, C., Lang, N. P., & Pellegrini, G. (2011) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2011.02301.x · Cited by 20
FOXP3+ and CD25+ cells are reduced in patients with stage IV, grade C periodontitis: A comparative clinical study
da Motta, R. J. G., Almeida, L. Y., Villafuerte, K. R. V., Ribeiro‐Silva, A., León, J. E., & Tirapelli, C. (2019) · Journal of Periodontal Research · doi:10.1111/jre.12721 · Cited by 20
Cell Type–Specific Decomposition of Gingival Tissue Transcriptomes
Momen‐Heravi, F., Friedman, R. A., Albeshri, S., Sawle, A., Kebschull, M., Kuhn, A., & Papapanou, P. N. (2021) · Journal of Dental Research · doi:10.1177/0022034520979614 · Cited by 19
Effect of NonSurgical Periodontal Therapy on Plasma Levels of IL-17 in Chronic Periodontitis Patients with Well Controlled Type-II Diabetes Mellitus—A Clinical Study
Sunandhakumari, V. J., Sadasivan, A., Koshi, E., Krishna, A., Alim, A., & Sebastian, A. (2018) · Dentistry Journal · doi:10.3390/dj6020019 · Cited by 18
Radon Therapy for Autoimmune Diseases Pemphigus and Diabetes: 2 Case Reports
Kojima, S., Cuttler, J. M., Shimura, N., Koga, H., Murata, A., & Kawashima, A. (2019) · Dose-Response · doi:10.1177/1559325819850984 · Cited by 18
Expression of IL-22, IL-22R and IL-23 in the peri-implant soft tissues of patients with peri-implantitis
Luo, Z., Wang, H., Sun, Z., Luo, W., & Wu, Y. (2012) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2012.08.006 · Cited by 19
Brain-Derived Neurotrophic Factor in Chronic Periodontitis
Corrêa, J. D., Pereira, D. S., Madeira, M. F. M., Queiroz‐Junior, C. M., Souza, D. G., Teixeira, M. M., Costa, J. E., Teixeira, A. L., & Silva, T. A. (2014) · Mediators of Inflammation · doi:10.1155/2014/373765 · Cited by 18
Studies on the aetiopathogenesis of feline chronic gingivostomatitis
Dolieslager, S. M. J. (2013) · Enlighten: Theses (The University of Glasgow) · Cited by 18
Oral neutrophils are an independent marker of the systemic inflammatory response after cardiac bypass
Wilcox, M. E., Charbonney, E., d’Empaire, P. P., Duggal, A., Pinto, R., Javid, A., Dos Santos, C., Rubenfeld, G. D., Sutherland, S., Liles, W. C., et al. (2014) · Journal of Inflammation · doi:10.1186/s12950-014-0032-5 · Cited by 17
Advances of functional nanomaterials as either therapeutic agents or delivery systems in the treatment of periodontitis
Xu, Z., Wang, Y., Li, S., Li, Y., Chang, L., Yao, Y., & Peng, Q. (2025) · Biomaterials Advances · doi:10.1016/j.bioadv.2025.214326 · Cited by 18
Serum cytokines in periodontal diseases
Ahmad, P., Slots, J., & Siqueira, W. L. (2025) · Periodontology 2000 · doi:10.1111/prd.12629 · Cited by 17
Spontaneous destructive periodontitis and skeletal bone damage in transgenic mice carrying a human shared epitope-coding HLA-DRB1 allele
Gehlot, P., Volk, S. L., Rios, H. F., Jepsen, K. J., & Holoshitz, J. (2016) · RMD Open · doi:10.1136/rmdopen-2016-000349 · Cited by 16
Autotransplantation with Simultaneous Sinus Floor Elevation
Park, Y.-S., Baek, S., Lee, W., Kum, K., & Shon, W. (2011) · Journal of Endodontics · doi:10.1016/j.joen.2011.10.009 · Cited by 16

Authors: Gaffen, S. L., & Hajishengallis, G.
Affiliations: University of Louisville (US)
Corresponding author: Gaffen, S.L.
ORCID: Gaffen, S.L.
Hajishengallis, G.
Venue: Journal of Dental Research
Publisher: SAGE Publications
Published: 2008-09
Volume: 87
Issue: 9
Pages: 817-828
ISSN: 0022-0345 (ISSN-L)
1544-0591
DOI: 10.1177/154405910808700908
PMC: PMC2692983
OpenAlex: W2036608242
Cited by: 334
References: 171
Citations by year: 2026: 12 · 2025: 13 · 2024: 14 · 2023: 11 · 2022: 8 · 2021: 17 · 2020: 18 · 2019: 22 · 2018: 14 · 2017: 24 · 2016: 19 · 2015: 20 · 2014: 27 · 2013: 29 · 2012: 25
FWCI: 2.89
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Dental Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (R21AI049329, AI49329, R01AI049329)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR054389, R01AR054389)
National Institute of Dental and Craniofacial Research (R01DE018292, DE-015254, DE017138, R01DE015254, DE018292, R01DE017138)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Keywords: periodontitis, Th1/Th2 paradigm, Th17 cells, IL-17, CD4+ T cells, periodontal disease pathogenesis, T cell immunity, host-pathogen interaction, periodontal pathogens, immunomodulatory therapy, periodontal disease susceptibility
MeSH terms: Animals, Humans, Immunity, Cellular, Interleukins, Periodontitis, T-Lymphocyte Subsets, Th1 Cells, Th2 Cells, Models, Immunological, Interleukin-17

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A New Inflammatory Cytokine on the Block: Re-thinking Periodontal Disease and the Th1/Th2 Paradigm in the Context of Th17 Cells and IL-17

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks