Gaffen, Sarah L.

The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing

Gaffen, S. L., Jain, R., Garg, A. V., & Cua, D. J. (2014) · Nature reviews. Immunology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 1,585

Structure and signalling in the IL-17 receptor family

Gaffen, S. L. (2009) · Nature reviews. Immunology

Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

Cited by 1,475

The IL-17 Family of Cytokines in Health and Disease

McGeachy, M. J., Cua, D. J., & Gaffen, S. L. (2019) · Immunity

Psoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

Cited by 1,443

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

Conti, H. R., Shen, F., Nayyar, N., Stocum, E., Sun, J. N., Lindemann, M. J., Ho, A. W., Hai, J. H., Yu, J. J., Jung, J. W., et al. (2009) · Journal of Experimental Medicine

Antifungal resistance and susceptibilityPsoriasis: Treatment and Pathogenesis

Cited by 1,024

Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease

Onishi, R. M., & Gaffen, S. L. (2010) · Immunology

Psoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

Cited by 894

IL-17 Signaling: The Yin and the Yang

Amatya, N., Garg, A. V., & Gaffen, S. L. (2017) · Trends in Immunology

Psoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

Cited by 785

Functional Cooperation between Interleukin-17 and Tumor Necrosis Factor-α Is Mediated by CCAAT/Enhancer-binding Protein Family Members

Ruddy, M. J., Wong, G. C., Liu, X. K., Yamamoto, H., Kasayama, S., Kirkwood, K. L., & Gaffen, S. L. (2004) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 364

Th17 cells in immunity to Candida albicans

Hernández-Santos, N., & Gaffen, S. L. (2012) · Cell Host & Microbe

Antifungal resistance and susceptibilityPsoriasis: Treatment and Pathogenesis

Cited by 361

A New Inflammatory Cytokine on the Block: Re-thinking Periodontal Disease and the Th1/Th2 Paradigm in the Context of Th17 Cells and IL-17

Gaffen, S. L., & Hajishengallis, G. (2008) · Journal of Dental Research

Oral microbiology and periodontitis researchPsoriasis: Treatment and Pathogenesis

Cited by 334

IL-17–Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicans

Conti, H. R., & Gaffen, S. L. (2015) · The Journal of Immunology

Antifungal resistance and susceptibilityIL-33, ST2, and ILC Pathways

Cited by 301

Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-α-induced genes in bone cells

Shen, F., Ruddy, M. J., Plamondon, P., & Gaffen, S. L. (2004) · Journal of Leukocyte Biology

Bone Metabolism and DiseasesCytokine Signaling Pathways and Interactions

Cited by 268

Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections

Conti, H. R., Peterson, A. C., Brane, L., Huppler, A. R., Hernández-Santos, N., Whibley, N., Garg, A. V., Simpson-Abelson, M. R., Gibson, G. A., Mamo, A. J., et al. (2014) · Journal of Experimental Medicine

T-cell and B-cell ImmunologyAntifungal resistance and susceptibility

Cited by 254

IL-17 Receptor Signaling in Oral Epithelial Cells Is Critical for Protection against Oropharyngeal Candidiasis

Conti, H. R., Bruno, V. M., Childs, E. E., Daugherty, S., Hunter, J. P., Mengesha, B. G., Saevig, D. L., Hendricks, M. R., Coleman, B. M., Brane, L., et al. (2016) · Cell Host & Microbe

Antifungal resistance and susceptibilityAntimicrobial Peptides and Activities

Cited by 177

Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression

Maitra, A., Shen, F., Hanel, W., Mossman, K., Tocker, J., Swart, D., & Gaffen, S. L. (2007) · Proceedings of the National Academy of Sciences

Psoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

Cited by 165

MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation

Garg, A. V., Amatya, N., Chen, K., Cruz, J. A., Grover, P., Whibley, N., Conti, H. R., Hernandez Mir, G., Sirakova, T., Childs, E. C., et al. (2015) · Immunity

Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

Cited by 145

The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling

Garg, A. V., Ahmed, M., Vallejo, A. N., Ma, A., & Gaffen, S. L. (2013) · Science Signaling

NF-κB Signaling PathwaysPsoriasis: Treatment and Pathogenesis

Cited by 128

Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis

Aggor, F. E. Y., Break, T. J., Trevejo-Nuñez, G., Whibley, N., Coleman, B. M., Bailey, R. D., Kaplan, D. H., Naglik, J. R., Shan, W., Shetty, A. C., et al. (2020) · Science Immunology

Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

Cited by 119

IL-17RC: a partner in IL-17 signaling and beyond

Ho, A. W., & Gaffen, S. L. (2010) · Seminars in Immunopathology

Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

Cited by 104

The m 6 A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis

Bechara, R., Amatya, N., Bailey, R. D., Li, Y., Aggor, F. E. Y., Li, D.-D., Jawale, C. V., Coleman, B. M., Dai, N., Gokhale, N. S., et al. (2021) · Science Immunology

RNA modifications and cancerSystemic Lupus Erythematosus Research

Cited by 89

A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss

Goswami, J., Hernández‐Santos, N., Zuniga, L. A., & Gaffen, S. L. (2009) · European Journal of Immunology

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 87

MCPIP1/Regnase-1 Restricts IL-17A- and IL-17C-Dependent Skin Inflammation

Monin, L., Gudjonsson, J. E., Childs, E. E., Amatya, N., Xing, X., Verma, A. H., Coleman, B. M., Garg, A. V., Killeen, M., Mathers, A., et al. (2017) · The Journal of Immunology

Psoriasis: Treatment and PathogenesisDermatology and Skin Diseases

Cited by 82

IL-17 integrates multiple self-reinforcing, feed-forward mechanisms through the RNA-binding protein Arid5a

Amatya, N., Childs, E. E., Cruz, J. A., Aggor, F. E. Y., Garg, A. V., Berman, A. J., Gudjonsson, J. E., Atasoy, U., & Gaffen, S. L. (2018) · Science Signaling

Psoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

Cited by 75

Interleukin-17-induced protein lipocalin 2 is dispensable for immunity to oral candidiasis

Ferreira, M. C., Whibley, N., Mamo, A. J., Siebenlist, U., Chan, Y. R., & Gaffen, S. L. (2014) · Infection and Immunity

Antifungal resistance and susceptibilityImmunodeficiency and Autoimmune Disorders

Cited by 72

The Candida albicans toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways

Nikou, S.-A., Zhou, C., Griffiths, J. S., Kotowicz, N. K., Coleman, B. M., Green, M. J., Moyes, D. L., Gaffen, S. L., Naglik, J. R., & Parker, P. J. (2022) · Science Signaling

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 65