The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
V irulence F actors ofE nterococcus faecalis: R elationship to E ndodontic D isease
Abstract
Enterococcus faecalis is a micro-organism that can survive extreme challenges. Its pathogenicity ranges from life-threatening diseases in compromised individuals to less severe conditions, such as infection of obturated root canals with chronic apical periodontitis. In the latter situation, the infecting organisms are partly shielded from the defense mechanisms of the body. In this article, we review the virulence factors of E. faecalis that may be related to endodontic infection and the periradicular inflammatory response. The most-cited virulence factors are aggregation substance, surface adhesins, sex pheromones, lipoteichoic acid, extracellular superoxide production, the lytic enzymes gelatinase and hyaluronidase, and the toxin cytolysin. Each of them may be associated with various stages of an endodontic infection as well as with periapical inflammation. While some products of the bacterium may be directly linked to damage of the periradicular tissues, a large part of the tissue damage is probably mediated by the host response to the bacterium and its products.
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Cited by
The ecology, epidemiology and virulence of Enterococcus
Fisher, K., & Phillips, C. (2009) · Microbiology · doi:10.1099/mic.0.026385-0 · Cited by 1,227
Present status and future directions: Microbiology of endodontic infections
Siqueira, J. F., & Rôças, I. N. (2022) · International Endodontic Journal · doi:10.1111/iej.13677 · Cited by 437
van Reenen, C. A., & Dicks, L. M. T. (2011) · Archives of Microbiology · doi:10.1007/s00203-010-0668-3 · Cited by 167
Identification of surface proteins in Enterococcus faecalis V583
Bøhle, L. A., Riaz, T., Egge-Jacobsen, W., Skaugen, M., Busk, Ø. L., Eijsink, V. G., & Mathiesen, G. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-135 · Cited by 67
Lennard, K. S., Goosen, R. W., & Blackburn, J. M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0166282 · Cited by 45
Metadata
- Authors
- Kayaoglu, G., & Ørstavik, D.
- Venue
- Critical Reviews in Oral Biology & Medicine
- Publisher
- SAGE Publications
- Published
- 2004-09
- Volume
- 15
- Issue
- 5
- Pages
- 308-320
- ISSN
- 1045-4411 (ISSN-L)
- 1544-1113
- OpenAlex
- W2116907180
- Cited by
- 488
- References
- 137
- FWCI
- 9.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kayaoglu, G., & Ørstavik, D. (2004). V irulence F actors ofE nterococcus faecalis: R elationship to E ndodontic D isease. Critical Reviews in Oral Biology & Medicine. https://doi.org/10.1177/154411130401500506
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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