The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
The Developmental Origins of Health and Disease (DOHaD)
Open accessAbstract
For years many have believed that genetic heritage defined one’s destiny, if an individual would grow to be healthy, or if he or she would suffer from chronic illness or cancer. Recent scientific evidence and the field of epigenetics has proven this to be untrue. Certainly, the DNA sequence and the genetic code are fixed; but the field of epigenetics has shown how methylation and other chemical modifications of the genome directly influence the production of proteins that can alter the phenotype of an organism. This article will lay out the supporting research, the details on how the internal and external environments influence genetic function, and will allow the reader to develop an action plan necessary to influence the genetic code, with the goal of then moving the individual toward optimal health. These research details will enable health care professionals in every field of medicine to work with patients on positively influencing the genetic output in order to improve the quality of life and longevity.
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“At its locus, it leads to a change in chromatin structure (from heterochromatin to euchromatin), and methylation marks have also been replenished at this level mediated by the mixed lineage leukemia (MLL) enzyme.”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [87]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
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“The overexpression of TNF-α has been observed in a wide variety of inflammatory diseases, such as rheumatoid arthritis, Crohn’s disease, ulcerative colitis, and asthma [86,87].”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [87]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“To cite an example, during tumorigenic progression, the loss of the expression of tumor suppressors—such as RB1; breast cancer type 1, BRCA1; anaphase promoting complex, APC; DNA mismatch repair protein MLH1; and Von Hippel–Lindau tumor suppressor VHL—has been observed due to hypermethylation at the promoter level.”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [87]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Likewise, it has been reported that there are miRNAs that target the BACE1 protein that regulates the production of amyloid beta platelets, Aβ, which, when accumulated, contribute to the neuroinflammation and progression of this disease [86,87,88].”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [87]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“On the other hand, in Alzheimer’s disease, for example, changes have been identified in the methylation status of proteins such as human clusterin CLU; ATP binding cassette subfamily A member 7 ABCA7; MS4A6A; and CD2AP, which have been reported to contribute to the development of the disease.”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [87]
Experimental — accuracy not yet measured
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“As an example of the above, it has been described that TNF-α undergoes epigenetic modifications at the level of DNA methylation in its promoter (hypermethylation and hypomethylation) to regulate its expression or at the level of histone modifications due to acetylation orchestrated by the enzymes activating transcription factor 2, ATF2, and the CREB binding protein (CBP).”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [87]
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Citations
Cites
Persistent epigenetic differences associated with prenatal exposure to famine in humans
Heijmans, B. T., Tobi, E. W., Stein, A. D., Putter, H., Blauw, G. J., Susser, E. S., Slagboom, P. E., & Lumey, L. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806560105 · Cited by 3,082
The Dutch Famine and Its Long-Term Consequences for Adult Health
Roseboom, T., de Rooij, S., & Painter, R. (2006) · Early Human Development · doi:10.1016/j.earlhumdev.2006.07.001 · Cited by 1,137
Catalano, P., & Ehrenberg, H. M. (2006) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.00989.x · Cited by 828
Predicting Preschooler Obesity at Birth: The Role of Maternal Obesity in Early Pregnancy
Whitaker, R. C. (2004) · PEDIATRICS · doi:10.1542/peds.114.1.e29 · Cited by 817
In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism
Radford, E. J., Ito, M., Shi, H., Corish, J. A., Yamazawa, K., ISGANAITIS, E. M., Seisenberger, S., Hore, T. A., Reik, W., Erkek, S., et al. (2014) · Science · doi:10.1126/science.1255903 · Cited by 627
The developmental origins of well–being
Barker, D. J. P. (2004) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2004.1518 · Cited by 378
Ornish, D. M., Magbanua, M. J. M., Weidner, G., WEINBERG, V. K., Kemp, C., Green, C., Mattie, M. D., Marlin, R. O., Simko, J. P., Shinohara, K., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803080105 · Cited by 300
Transgenerational developmental programming
Aiken, C., & Ozanne, S. E. (2013) · Human Reproduction Update · doi:10.1093/humupd/dmt043 · Cited by 295
Developmental Origins of Adult Disease
Langley‐Evans, S. C., & McMullen, S. (2010) · Medical Principles and Practice · doi:10.1159/000273066 · Cited by 273
Prenatal Multivitamin Supplementation and Rates of Congenital Anomalies: A Meta-Analysis
Goh, Y. I., Bollano, E., Einarson, T. R., & Koren, G. (2006) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)32227-7 · Cited by 269
Research works printed but not linked: 1
- Wallach JD, 2014, Epigenetics: The Death of the Genetic Theory of Disease Transmission
Cited by
Sorted by citations
Exploring the Role of Neuroplasticity in Development, Aging, and Neurodegeneration
Marzola, P., Melzer, T., Pavesi, E., Gil-Mohapel, J., & Brocardo, P. S. (2023) · Brain Sciences · doi:10.3390/brainsci13121610 · Cited by 281
Zhan, Y., Liu, J., Lu, Z., Yue, H., Zhang, J., & Jiang, Y. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137420 · Cited by 120
Endocrine disrupting chemicals and male fertility: from physiological to molecular effects
Lahimer, M., Diwan, M. A., Montjean, D., Cabry, R., Bach, V., Ajina, M., Ali, H. B., Benkhalifa, M., & Khorsi‐Cauet, H. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1232646 · Cited by 95
Marumure, J., Simbanegavi, T. T., Makuvara, Z., Karidzagundi, R., Alufasi, R., Goredema, M., Gufe, C., Chaukura, N., Halabowski, D., & Gwenzi, W. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.141699 · Cited by 58
Xiao, X., Gao, M. C., Zhou, Y., Xu, S.-L., Knibbs, L. D., Heinrich, J., Dharmage, S. C., Morawska, L., Lin, S., Jalaludin, B. B., et al. (2021) · International Journal of Epidemiology · doi:10.1093/ije/dyab164 · Cited by 47
Metadata
- Authors
- Lacagnina, S.
- Affiliations
- Lee Memorial Hospital (US)
- Corresponding author
- Lacagnina, Salvatore
- Venue
- American Journal of Lifestyle Medicine
- Publisher
- SAGE Publications
- Published
- 2019-10-11
- Volume
- 14
- Issue
- 1
- Pages
- 47-50
- ISSN
- 1559-8276 (ISSN-L)
- 1559-8284
- PMC
- PMC6933571
- OpenAlex
- W2979300097
- Cited by
- 244
- References
- 23
- Citations by year
- 2026: 96 · 2025: 71 · 2024: 42 · 2023: 19 · 2022: 4 · 2021: 8 · 2020: 2
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Lifestyle Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- developmental origins of health and disease, epigenetics, DNA methylation, gene-environment interaction, phenotypic expression, lifestyle intervention, health promotion, longevity, chronic disease prevention
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