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Cited by 281Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Exploring the Role of Neuroplasticity in Development, Aging, and Neurodegeneration

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Marzola, Patrícia, Melzer, Thayza, Pavesi, Eloisa, Gil-Mohapel, Joana, Brocardo, Patricia S.·2023·Brain Sciences
DOI 10.3390/brainsci13121610PMC PMC10741468
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Abstract

Neuroplasticity refers to the ability of the brain to reorganize and modify its neural connections in response to environmental stimuli, experience, learning, injury, and disease processes. It encompasses a range of mechanisms, including changes in synaptic strength and connectivity, the formation of new synapses, alterations in the structure and function of neurons, and the generation of new neurons. Neuroplasticity plays a crucial role in developing and maintaining brain function, including learning and memory, as well as in recovery from brain injury and adaptation to environmental changes. In this review, we explore the vast potential of neuroplasticity in various aspects of brain function across the lifespan and in the context of disease. Changes in the aging brain and the significance of neuroplasticity in maintaining cognitive function later in life will also be reviewed. Finally, we will discuss common mechanisms associated with age-related neurodegenerative processes (including protein aggregation and accumulation, mitochondrial dysfunction, oxidative stress, and neuroinflammation) and how these processes can be mitigated, at least partially, by non-invasive and non-pharmacologic lifestyle interventions aimed at promoting and harnessing neuroplasticity.

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  • Brain regions critically involved in cognition, such as the hippocampus, amygdala, and prefrontal cortex, are especially vulnerable in AD.

    “Brain regions critically involved in cognition, such as the hippocampus, amygdala, and prefrontal cortex, are especially vulnerable [84].”

    From Toward a Unified Framework in Molecular Neurobiology of Alzheimer’s Disease: Revisiting the Pathophysiological Hypotheses (2026) · cites this paper as [84]

    Section 4.3 says the hippocampus is particularly affected by aging, and Section 4.1 says aging particularly affects the hippocampus and cerebral cortex while increasing the risk of AD. Neither passage establishes that the hippocampus, amygdala, and prefrontal cortex are all especially vulnerable in AD; the discussion of the amygdala and prefrontal cortex in Section 3.3 concerns adolescence. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

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Authors
Marzola, P., Melzer, T., Pavesi, E., Gil-Mohapel, J., & Brocardo, P. S.
Affiliations
  • Universidade Federal de Santa Catarina (BR)
  • Department of Morphological Sciences and Graduate Neuroscience Program, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis 88040-900, SC, Brazil
  • Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada
ORCID
Venue
Brain Sciences
Publisher
MDPI AG
Published
2023-11-21
Volume
13
Issue
12
Pages
1610
ISSN
2076-3425 (ISSN-L)
DOI
10.3390/brainsci13121610
PMC
PMC10741468
OpenAlex
W4388867239
Cited by
281
References
52
Citations by year
2026: 121 · 2025: 141 · 2024: 19
FWCI
10.72
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (2021TR1523, UVic-FAPESP SPRINT 1/2018)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; Brazil) Research Productivity Fellowship (2021TR1523, UVic-FAPESP SPRINT 1/2018)
  • University of Victoria (UVic, Victoria, BC, Canada) – São Paulo Research Foundation (FAPESP, São Paulo, SP, Brazil) SPRINT partnership (2021TR1523, UVic-FAPESP SPRINT 1/2018)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
neuroplasticity, brain development, brain aging, neurodegeneration, synaptic plasticity, neurogenesis, learning and memory, brain injury recovery, protein aggregation, mitochondrial dysfunction, oxidative stress, neuroinflammation, lifestyle intervention

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