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Cited by 48Cardiovascular Health and Risk FactorsGenetics, Aging, and Longevity in Model OrganismsHealth and Lifestyle Studies

Lessons Learned From Blue Zones, Lifestyle Medicine Pillars and Beyond: An Update on the Contributions of Behavior and Genetics to Wellbeing and Longevity

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Kreouzi, Magdalini, Theodorakis, Nikolaos, Constantinou, Constantina·2024·American Journal of Lifestyle Medicine
DOI 10.1177/15598276221118494PMC PMC11536469
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Abstract

Blue Zones are regions of the world that have a higher number of individuals who live longer than the expected average. The current paper revisits principles previously identified to be common in Blue Zones and to be contributing to longevity ( move naturally, eat wisely, improve resilience to stress, get adequate sleep, keep strong family ties, stimulate strong community support, respect for the planet and having a purpose in life’), compares these to the 6 pillars of Lifestyle Medicine ( healthy eating, exercising, avoidance of smoking and other risky substances, stress management, restorative sleep, and forming and maintaining relationships) and reviews new studies investigating the association between behavioral factors and longevity. In addition to the role of behavior, the review also discusses the important role of genetics and emphasizes the importance of conducting further research to understand how behavioral and genetic factors may affect molecular pathways with consequent effects on wellbeing and longevity.

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  • Blue Zones share common dietary, lifestyle, and social factors that contribute to the remarkable health and longevity of their residents.

    “Despite their diverse cultural and environmental contexts, Blue Zones share common dietary, lifestyle, and social factors that contribute to the remarkable health and longevity of their residents [7,148,149,150,151,152].”

    From The Power of Environment: A Comprehensive Review of the Exposome's Role in Healthy Aging, Longevity, and Preventive Medicine-Lessons from Blue Zones and Cilento (2025) · cites this paper as [148]

    The Introduction identifies common Blue Zone factors involving eating, activity, family ties, and community support that could contribute to longevity. The Conclusions associate these factors with wellbeing and longevity but say there is no specific scientific explanation for Blue Zone residents’ exceptional survival. The claim’s definite wording, “contribute,” is stronger than the paper’s qualified account. (LLM, conf=0.86)

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Authors
Kreouzi, M., Theodorakis, N., & Constantinou, C.
Affiliations
University of Nicosia (CY)
Corresponding author
Constantinou, Constantina
ORCID
Venue
American Journal of Lifestyle Medicine
Publisher
SAGE Publications
Published
2022-08-20
Volume
18
Issue
6
Pages
750-765
ISSN
  • 1559-8276 (ISSN-L)
  • 1559-8284
DOI
10.1177/15598276221118494
PMC
PMC11536469
OpenAlex
W4292430049
Cited by
48
References
100
Citations by year
2026: 13 · 2025: 21 · 2024: 7 · 2023: 7
FWCI
1.78
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Lifestyle Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Health Professions › General Health Professions › Health and Lifestyle Studies
Keywords
Blue Zones, longevity, lifestyle medicine, healthy eating, physical activity, stress management, sleep, interpersonal relationships, genetic factors, well-being, molecular pathways

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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