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Cited by 27Retinoids in leukemia and cellular processesAntioxidant Activity and Oxidative StressNutrition and Health Studies

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Vitamin A and Carotenoid Toxicity

Open access
Blomhoff, Rune·2001·Food and Nutrition Bulletin
DOI 10.1177/156482650102200309
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Abstract

Large differences in time and dose needed to induce hypervitaminosis A have been observed. High doses of vitamin A in food and oily solutions are well tolerated, whereas emulsified preparations have higher toxicity. Chronic hypervitaminosis seems to be induced following daily doses of 300,000 to 600,000 IU of vitamin A (90–180 mg of retinol) in oily preparations for many months or years, whereas teratogenicity may be induced by daily doses as low as 40,000 IU of vitamin A (12 mg of retinol) in oil during the first trimester. for the provitamin A, β-carotene, serious adverse effects have been reported in large-scale prospective randomized trials: four years of supplementation with 20 to 30 mg β-carotene per day was associated with increased risk of lung cancer and cardiovascular disease among smokers and workers exposed to asbestos. These results strongly suggest that high doses of β-carotene should not be recommended for any group until the safety of such doses can be established.

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  • High levels of vitamin A are teratogenic and can cause foetal defects in the developing foetus.

    “Pregnant women must be cautious when taking vitamin A supplements, as high levels of vitamin A are teratogenic and can cause foetal defects in the developing foetus [1,12,13].”

    From The Role of Vitamin A in Retinal Diseases (2022) · cites this paper as [13]

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Cited by

Sorted by citations

  • The Role of Vitamin A in Retinal Diseases

    Sajovic, J., Meglič, A., Glavač, D., Markelj, Š., Hawlina, M., & Fakin, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031014 · Cited by 109

    “In the acute form, the symptoms appear a few hours after the intake, and may include dizziness, disturbances of consciousness, irritability, nose bleeding, headache, nausea, vomiting, and abdominal pain [9,10,13].”
    Background

Metadata

Authors
Blomhoff, R.
Affiliations
University of Oslo (NO)
Corresponding author
Blomhoff, Rune
ORCID
Blomhoff, Rune
Venue
Food and Nutrition Bulletin
Publisher
SAGE Publications
Published
2001-01
Volume
22
Issue
3
Pages
320-334
ISSN
  • 0379-5721 (ISSN-L)
  • 1564-8265
DOI
10.1177/156482650102200309
OpenAlex
W2523069750
Cited by
27
References
1
Citations by year
2026: 2 · 2025: 1 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 1 · 2016: 1
FWCI
0.23
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
Food and Nutrition Bulletin (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Keywords
vitamin A toxicity, beta-carotene, teratogenicity, retinol, lung cancer risk, cardiovascular disease, smokers, asbestos exposure, provitamin A

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