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THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT
Abstract
A group of apparently unrelated endocrine cells, some in endocrine glands, others in nonendocrine tissues, share a number of cytochemical and ultrastructural characteristics. These characteristics, from the initial letters of four of which the term APUD is derived, indicate the possession of a common metabolic pattern and common synthetic, storage and secretion mechanisms. It is postulated that the various characteristics reflect the production and storage of hormone precursor protein which has a predominantly random coil conformation. Several explanations are possible to account for the APUD characteristics but if the cells, in fact, share a common ancestor the only possible candidate is the neural crest cell.
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Citations
Cited by
Coexistence of peptides and classical neurotransmitters
Lundberg, J. M., & Hökfelt, T. (1983) · Trends in Neurosciences · doi:10.1016/0166-2236(83)90149-2 · Cited by 561
Enkephalin-like immunoreactivity in gland cells and nerve terminals of the adrenal medulla
Schultzberg, M., Lundberg, J. M., Ho¨kfelt, T., Terenius, L., Brandt, J., Elde, R. P., & Goldstein, M. (1978) · Neuroscience · doi:10.1016/0306-4522(78)90137-9 · Cited by 555
Neuropeptides and the Microbiota-Gut-Brain Axis
Holzer, P., & Farzi, A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_9 · Cited by 451
Review lecture. Neurotransmitters and trophic factors in the autonomic nervous system.
Burnstock, G. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013648 · Cited by 373
Coexistence of peptides with classical neurotransmitters
Hökfelt, T., Millhorn, D., Seroogy, K., Tsuruo, Y., Ceccatelli, S., Lindh, B., Meister, B., Melander, T., Schalling, M., Bartfai, T., et al. (1987) · Experientia · doi:10.1007/bf01945354 · Cited by 332
Metadata
- Authors
- PEARSE, A. G. E.
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 1969-05
- Volume
- 17
- Issue
- 5
- Pages
- 303-313
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W2124663059
- Cited by
- 1,673
- References
- 0
- FWCI
- 16.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT. https://app.cochat.ai/papers/10.1177/17.5.303
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- PEARSE, A. G. E. (1969). THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT. Journal of Histochemistry & Cytochemistry. https://doi.org/10.1177/17.5.303
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