Nicotinamide: a vitamin able to shift macrophage differentiation toward macrophages with restricted inflammatory features
Open accessAbstract
The differentiation of human monocytes into macrophages is influenced by environmental signals. Here we asked in how far nicotinamide (NAM), a vitamin B 3 derivative known to play a major role in nicotinamide adenine dinucleotide (NAD)-mediated signaling events, is able to modulate monocyte differentiation into macrophages developed in the presence of granulocyte macrophage colony-stimulating factor (GM-MØ) or macrophage colony-stimulating factor (M-MØ). We found that GM-MØ undergo biochemical, morphological and functional modifications in response to NAM, whereas M-MØ were hardly affected. GM-MØ exposed to NAM acquired an M-MØ-like structure while the LPS-induced production of pro-inflammatory cytokines and COX-derived eicosanoids were down-regulated. In contrast, NAM had no effect on the production of IL-10 or the cytochrome P450-derived eicosanoids. Administration of NAM enhanced intracellular NAD concentrations; however, it did not prevent the LPS-mediated drain on NAD pools. In search of intracellular molecular targets of NAM known to be involved in LPS-induced cytokine and eicosanoid synthesis, we found NF-κB activity to be diminished. In conclusion, our data show that vitamin B 3 , when present during the differentiation of monocytes into GM-MØ, interferes with biochemical pathways resulting in strongly reduced pro-inflammatory features.
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NAM has immunomodulatory properties, and high NAM levels can reduce inflammatory cytokine production in macrophages.
“NAM has immunomodulatory properties, and high NAM levels can reduce inflammatory cytokine production in macrophages68”
From Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages (2020) · cites this paper as [68]
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Self-citationAdditional file 1 of Nicotinamide inhibits melanoma in vitro and in vivo
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Additional file 2 of Nicotinamide inhibits melanoma in vitro and in vivo
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- Authors
- Weiss, R., Schilling, E., Grahnert, A., Kölling, V., Dorow, J., Ceglarek, U., Sack, U., & Hauschildt, S.
- Affiliations
- University Hospital Leipzig (DE)
- Leipzig University (DE)
- Corresponding author
- Hauschildt, Sunna
- Venue
- Innate Immunity
- Publisher
- SAGE Publications
- Published
- 2015-09-18
- Volume
- 21
- Issue
- 8
- Pages
- 813-826
- ISSN
- 1753-4259 (ISSN-L)
- 1753-4267
- OpenAlex
- W2460643178
- Cited by
- 41
- References
- 50
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 7 · 2019: 8 · 2018: 2 · 2017: 1 · 2016: 3
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Innate Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung (BMBF 1315883, 1315883)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- nicotinamide, nicotinic acid, monocyte differentiation, macrophage polarization, M&Ms, macrophage colony-stimulating factor, granulocyte colony-stimulating factor, lipopolysaccharide, inflammatory cytokines, eicosanoids, IL-10, cytochrome P450, NAD+ signaling, NF-κB, anti-inflammatory macrophages
- MeSH terms
- Cell Differentiation, Cells, Cultured, Gene Expression Regulation, Humans, Inflammation, Macrophages, Monocytes, NAD, Niacinamide, Vitamin B Complex, Signal Transduction, Eicosanoids, Macrophage Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, NF-kappa B
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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