Cited by 9Fibromyalgia and Chronic Fatigue Syndrome ResearchChemokine receptors and signalingInflammasome and immune disorders

Altered release of chemokines by phagocytes from fibromyalgia patients: a pilot study

Open access
García, Juan José, Carvajal-Gil, Julián, Guerrero-Bonmatty, Rafael·2016·Innate Immunity

Abstract

Fibromyalgia (FM) is a syndrome characterized by widespread chronic pain and is associated with elevated systemic inflammatory biomarkers, and an elevated innate cellular response. The aim of this study was to determine if fibromyalgia patients have altered ability to release pro-inflammatory chemokines by isolated neutrophils and monocytes. The study participants were women diagnosed with FM ( n = 6) and a control group of healthy women (HW) ( n = 6). Supernatant concentrations of eotaxin (CCL11), human macrophage-derived chemokine (MDC) (CCL22) and growth regulated-oncogene (GRO-α) (CXCL1) released by both monocytes and neutrophils either resting or stimulated by LPS were determined by ELISA and compared between the FM and HW groups. Both resting and activated monocytes from FM patients released more eotaxin, MDC and GRO-α than those from HW. However, there were no significant differences in the release of chemokines from neutrophils of FM patients and the ones from healthy women. In conclusion, monocytes from women with FM are deregulated, releasing higher amounts of eotaxin, MDC and GRO-α than healthy individuals. This fact does not occur in neutrophils from women with FM.

Integrity signals

Registry

Crossref · 10.1177/1753425915602959

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Macrophages released higher serum concentrations of inflammatory chemokines, such as macrophage-derived chemokine/CCL22, promoting nociplastic pain by regulating immune cell migration and local infiltration.

    “Juan J García et al. found that the macrophages released higher serum concentrations of inflammatory chemokines, such as macrophage-derived chemokine (MDC)/CCL22, promoting NPP by regulating immune cell migration and local infiltration (60).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
García, J. J., Carvajal-Gil, J., & Guerrero-Bonmatty, R.
Affiliations
Universidad de Extremadura (ES)
Corresponding author
García, Juan José
Venue
Innate Immunity
Published
2015-09-03
Volume
22
Issue
1
Pages
3-8
ISSN
  • 1753-4259 (ISSN-L)
  • 1753-4267
OpenAlex
W1783256714
Cited by
9
References
35
Citations by year
2026: 3 · 2024: 2 · 2018: 2 · 2017: 1 · 2016: 1
FWCI
1.09
Type
journal article
Language
en
Open access
Locations
  • Innate Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repository University of Extremadura (University of Extremadura) (acceptedVersion, other-oa)
Funders
Junta de Extremadura
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords
fibromyalgia, chemokine secretion, monocytes, neutrophils, eotaxin, CCL22, CCL17, CXCL1, lipopolysaccharide stimulation, chronic pain, women
MeSH terms
Adult, Cells, Cultured, Female, Fibromyalgia, Humans, Immunity, Innate, Middle Aged, Monocytes, Neutrophils, Phagocytosis, Pilot Projects, Chemokine CXCL1, Chemokine CCL11, Chemokine CCL22, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review