Altered release of chemokines by phagocytes from fibromyalgia patients: a pilot study
Open accessAbstract
Fibromyalgia (FM) is a syndrome characterized by widespread chronic pain and is associated with elevated systemic inflammatory biomarkers, and an elevated innate cellular response. The aim of this study was to determine if fibromyalgia patients have altered ability to release pro-inflammatory chemokines by isolated neutrophils and monocytes. The study participants were women diagnosed with FM ( n = 6) and a control group of healthy women (HW) ( n = 6). Supernatant concentrations of eotaxin (CCL11), human macrophage-derived chemokine (MDC) (CCL22) and growth regulated-oncogene (GRO-α) (CXCL1) released by both monocytes and neutrophils either resting or stimulated by LPS were determined by ELISA and compared between the FM and HW groups. Both resting and activated monocytes from FM patients released more eotaxin, MDC and GRO-α than those from HW. However, there were no significant differences in the release of chemokines from neutrophils of FM patients and the ones from healthy women. In conclusion, monocytes from women with FM are deregulated, releasing higher amounts of eotaxin, MDC and GRO-α than healthy individuals. This fact does not occur in neutrophils from women with FM.
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Macrophages released higher serum concentrations of inflammatory chemokines, such as macrophage-derived chemokine/CCL22, promoting nociplastic pain by regulating immune cell migration and local infiltration.
“Juan J García et al. found that the macrophages released higher serum concentrations of inflammatory chemokines, such as macrophage-derived chemokine (MDC)/CCL22, promoting NPP by regulating immune cell migration and local infiltration (60).”
From Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization (2026) · cites this paper as [60]
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“Juan J Garc ı ́ a et al. found that the macrophages released higher serum concentrations of in fl ammatory chemokines, such as macrophage-derived chemokine (MDC)/CCL22, promoting NPP by regulating immune cell migration and local in fi ltration (60).”
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- Authors
- García, J. J., Carvajal-Gil, J., & Guerrero-Bonmatty, R.
- Affiliations
- Universidad de Extremadura (ES)
- Corresponding author
- García, Juan José
- ORCID
- García, Juan José
- Venue
- Innate Immunity
- Publisher
- SAGE Publications
- Published
- 2015-09-03
- Volume
- 22
- Issue
- 1
- Pages
- 3-8
- ISSN
- 1753-4259 (ISSN-L)
- 1753-4267
- OpenAlex
- W1783256714
- Cited by
- 9
- References
- 35
- Citations by year
- 2026: 3 · 2024: 2 · 2018: 2 · 2017: 1 · 2016: 1
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Update notices
- correction (2016-03-11)
- Open access
- bronze
- doi.org
- Locations
- Innate Immunity (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository University of Extremadura (University of Extremadura) (acceptedVersion, other-oa)
- Funders
- Junta de Extremadura
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- fibromyalgia, chemokine secretion, monocytes, neutrophils, eotaxin, CCL22, CCL17, CXCL1, lipopolysaccharide stimulation, chronic pain, women
- MeSH terms
- Adult, Cells, Cultured, Female, Fibromyalgia, Humans, Immunity, Innate, Middle Aged, Monocytes, Neutrophils, Phagocytosis, Pilot Projects, Chemokine CXCL1, Chemokine CCL11, Chemokine CCL22, Young Adult
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