Proton-pump inhibitors for the treatment of functional dyspepsia

Suzuki, Hidekazu; Okada, Sawako; Hibi, Toshifumi

doi:10.1177/1756283x11398735

Cited by 22Gastrointestinal motility and disordersGastroesophageal reflux and treatmentsHelicobacter pylori-related gastroenterology studies

Proton-pump inhibitors for the treatment of functional dyspepsia

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Suzuki, Hidekazu, Okada, Sawako, Hibi, Toshifumi·2011·Therapeutic Advances in Gastroenterology

DOI 10.1177/1756283x11398735PMC PMC3131167

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Abstract

In the Rome III classification, functional dyspepsia (FD) has been further subcategorized into two different syndromes, namely, epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS). Acid-related pathophysiology seems to be mainly responsible for EPS, and antisecretory agents such as proton-pump inhibitors (PPIs) seem to be effective mainly against EPS. However, recent information as to the relationship between initial duodenal acid sensitization in the early postprandial phase and delayed gastric emptying in the later postprandial phase would suggest the amelioration of PDS by antisecretory agents. In the present review, we summarized the recent literature on the direct and indirect effect of PPIs in FD (including not only Rome III, but also Rome II criteria). The effects of PPIs against FD are heterogeneous, depending on the protocol of the clinical studies, and the inclusion criteria of each randomized controlled trial (primary care or tertiary care population). As the placebo effects cannot be ignored in this disease, a placebo-controlled study would be necessary, at least for the evaluation of the effect of each agent on symptom relief in patients with FD. Further studies directly comparing PPIs with suitable placebos in terms of their effects in reducing the symptoms of endoscopically confirmed, Rome III-based FD are awaited.

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PPIs are the first-choice treatment for acid-related disorders such as bleeding, peptic ulcers, gastroesophageal reflux, erosive esophagitis (ERD) and certain dyspepsia subtypes.
“PPIs are the first-choice treatment for acid-related disorders such as bleeding, peptic ulcers, gastroesophageal reflux, erosive esophagitis (ERD) and certain dyspepsia subtypes[2-5].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [5]

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Authors: Suzuki, H., Okada, S., & Hibi, T.
Affiliations: Keio University (JP)
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
Corresponding author: Suzuki, Hidekazu
ORCID: Suzuki, Hidekazu
Venue: Therapeutic Advances in Gastroenterology
Publisher: SAGE Publications
Published: 2011-03-02
Volume: 4
Issue: 4
Pages: 219-226
ISSN: 1756-283X (ISSN-L)
1756-2848
DOI: 10.1177/1756283x11398735
PMC: PMC3131167
OpenAlex: W2128987347
Cited by: 22
References: 23
Citations by year: 2024: 1 · 2022: 3 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 2
FWCI: 1.31
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Therapeutic Advances in Gastroenterology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Keio University
Smoking Research Foundation
Japan Society for the Promotion of Science (22300169)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
Keywords: proton pump inhibitors, functional dyspepsia, epigastric pain syndrome, postprandial distress syndrome, antisecretory therapy, duodenal acid secretion, delayed gastric emptying, placebo effect, symptom relief

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Proton-pump inhibitors for the treatment of functional dyspepsia

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