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Cited by 4Pregnancy and preeclampsia studiesBirth, Development, and HealthCardiovascular Conditions and Treatments

The Effect of Intermittent Umbilical Cord Occlusion on Elastin Composition in the Ovine Fetus

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Thompson, Jennifer A., Gimbel, Sarah A., Richardson, Bryan S., Gagnon, Robert, Regnault, Timothy R. H.·2011·Reproductive Sciences
DOI 10.1177/1933719111401655
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Abstract

This study aimed to determine the effect of varying degrees of intermittent umbilical cord occlusion (UCO) on arterial elastin composition. Over 4 days, chronically catheterized late gestation fetal sheep received 5 total UCO per day lasting 1 min/h (mild group: n = 6), 2 min/h (moderate group: n = 4), 3 min/h (severe group; n = 6); or no occlusion (control group: n = 7). Each group was evaluated for elastin content of the carotid and superior mesenteric artery (SMA), the arterial pressure response to UCO, and plasma cortisol concentration. Elastin content of the carotid artery was significantly increased by severe UCO (9.5 µg/mg versus 6.4 µg/mg; P < .05) and insignificantly increased in mild and moderate groups, whereas UCO had no effect on elastin content of the SMA. This dose- and site-dependent response of the vasculature appears attributable to the hemodynamic changes that accompany UCO.

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  • A growth-restricted fetus has smaller coronary arteries, fewer but more immature cardiomyocytes, less elastin in the arteries, and fewer nephrons in the kidney.

    “For example, a growth-restricted fetus has smaller coronary arteries (288), fewer but more immature cardiomyocytes (55,348,394), less elastin in the arteries (152, 362, 526), and fewer nephrons in the kidney (22,352).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [526]

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Research works printed but not linked: 1

  1. Leung DYM, Glagov S, Mathews MB. Elastin and collagen accumulation in rabbit ascending aorta and pulmonary trunk during postnatal growth. Circ Res. 1977;41(3):316-323.

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Authors
Thompson, J. A., Gimbel, S. A., Richardson, B. S., Gagnon, R., & Regnault, T. R. H.
Affiliations
  • Western University (CA)
  • McGill University (CA)
Corresponding author
Thompson, Jennifer A.
ORCID
Venue
Reproductive Sciences
Publisher
Springer Science and Business Media LLC
Published
2011-10
Volume
18
Issue
10
Pages
990-997
ISSN
  • 1933-7191 (ISSN-L)
  • 1933-7205
DOI
10.1177/1933719111401655
OpenAlex
W2085406005
Cited by
4
References
41
Citations by year
2016: 1
FWCI
1.24
Type
journal article
Language
en
Open access
Licence
Locations
  • Reproductive Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • Scholarship@Western (Western University) (submittedVersion)
Funders
  • Children's Health Research Institute
  • Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
Keywords
fetal hypoxia, carotid artery, superior mesenteric artery, fetal sheep, plasma cortisol, fetal hemodynamics
MeSH terms
Animals, Blood Pressure, Carotid Arteries, Constriction, Elastin, Female, Fetal Hypoxia, Fetal Heart, Fetus, Hydrocortisone, Mesenteric Arteries, Pregnancy, Sheep, Umbilical Cord

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