Antioxidant and Anti-cholinesterase Activity of Globularia meridionalis Extracts and Isolated Constituents
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The antioxidant and anti-cholinesterase properties of Globularia meridional (Podp.) O. Schwarz (Globulariaceae) were investigated. G. meridionalis aerial parts and roots were extracted with methanol, and the total extract successively partitioned with n-hexane. The methanol fraction of the roots showed the highest antioxidant activity with IC 50 values of 8.0 and 2.1 μg/mL in the DPPH and β-carotene bleaching tests, respectively. From this fraction, three flavonoids, namely pectolinarigenin 7- O-β-glucoside, apigenin 7- O-β-glucoside and luteolin, and two phenylethanoids, namely acteoside and isoacteoside, were isolated. Potential anti-cholinesterase effects were assessed through the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibition assay. The n-hexane fraction of the roots exhibited the highest activity against both AChE and BChE with IC 50 values of 65.5 and 70.4 μg/mL, respectively.
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Tundis et al. and Zengin et al. showed that flavonoids, especially apigenin 7-glucoside, have a potential anti-cholinesterase effect, and that total methanolic extracts of SCGs and coffee silverskin have an enzyme-inhibitory effect.
“The above results follow those of Tundis et al. [35] and Zengin et al. [36], where flavonoids, according to the former, and especially apigenin 7-glucoside, showed a potential anti-cholinesterase effect, while the latter showed an enzyme-inhibitory effect for the total methanolic extracts of both SCGs and coffee silverskin.”
From The Valorization of Spent Coffee Ground Extract as a Prospective Insecticidal Agent against Some Main Key Pests of Phaseolus vulgaris in the Laboratory and Field (2022) · cites this paper as Tundis et al. [35]
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Acetylcholinesterase inhibitors from plants and fungi
Houghton, P. J., Ren, Y., & Howes, M.-J. (2006) · Natural Product Reports · doi:10.1039/b508966m · Cited by 584 · see citing works
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Hussein, H., Abouamer, W., Ali, H., Elkhadragy, M., Yehia, H., & Farouk, A. (2022) · Plants · doi:10.3390/plants11091124 · Cited by 20 · see citing works
- Authors
- Tundis, R., Bonesi, M., Menichini, F., Loizzo, M. R., Conforti, F., Statti, G., Pirisi, F. M., & Menichini, F.
- Affiliations
- University of Calabria (IT)
- University of Cagliari (IT)
- Corresponding author
- Tundis, Rosa
- ORCID
- Venue
- Natural Product Communications
- Publisher
- SAGE Publications
- Published
- 2012-08
- Volume
- 7
- Issue
- 8
- Pages
- 1015-20
- ISSN
- 1555-9475 (ISSN-L)
- 1934-578X
- OpenAlex
- W205569198
- Cited by
- 25
- References
- 1
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 2
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Natural Product Communications (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Funders
- Università di Pisa
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Keywords
- antioxidant activity, anticholinesterase activity, acetylcholinesterase inhibition, butyrylcholinesterase inhibition, flavonoids, luteolin, verbascoside, isoacteoside, phenylethanoids, plant extracts, roots, aerial parts
- MeSH terms
- Antioxidants, Butyrylcholinesterase, Cholinesterase Inhibitors, Plant Extracts, Plant Roots, Scrophulariaceae, Plant Components, Aerial
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