Acetylcholinesterase inhibitors from plants and fungi

A new and rapid colorimetric determination of acetylcholinesterase activity

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Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

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Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

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Crystal Structure of Human Butyrylcholinesterase and of Its Complexes with Substrate and Products

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Galanthamine from snowdrop?the development of a modern drug against Alzheimer?s disease from local Caucasian knowledge

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Cholinesterase inhibitors: new roles and therapeutic alternatives

Giacobini, E. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2003.11.017 · Cited by 559 · see citing works

Acetylcholinesterase: ‘classical’ and ‘non-classical’ functions and pharmacology

Silman, I., & Sussman, J. L. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.01.014 · Cited by 525 · see citing works

Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining

Rhee, I. K., van de Meent, M. H. M., Ingkaninan, K., & Verpoorte, R. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)00624-0 · Cited by 465 · see citing works

In-vitro Inhibition of Human Erythrocyte Acetylcholinesterase by Salvia lavandulaefolia Essential Oil and Constituent Terpenes

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Synergistic and antagonistic interactions of anticholinesterase terpenoids in Salvia lavandulaefolia essential oil

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Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts

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Plant-insect coevolution and inhibition of acetylcholinesterase

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2-Pyrone natural products and mimetics: isolation, characterisation and biological activity

McGlacken, G. P., & Fairlamb, I. J. S. (2005) · Natural Product Reports · doi:10.1039/b416651p · Cited by 357 · see citing works

Acetylcholinesterase inhibition by fasciculin: Crystal structure of the complex

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A rapid TLC bioautographic method for the detection of acetylcholinesterase and butyrylcholinesterase inhibitors in plants

Marston, A., Kissling, J., & Hostettmann, K. (2002) · Phytochemical Analysis · doi:10.1002/pca.623 · Cited by 345 · see citing works

Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity

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Three‐dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors

Harel, M., Kryger, G., Rosenberry, T. L., Mallender, W. D., Lewis, T., Fletcher, R. J., Guss, J. M., Silman, I., & Sussman, J. L. (2000) · Protein Science · doi:10.1110/ps.9.6.1063 · Cited by 299 · see citing works

Five Unique Compounds: Xyloketals from Mangrove Fungus Xylaria sp . from the South China Sea Coast

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Open "Back Door" in a Molecular Dynamics Simulation of Acetylcholinesterase

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Role of the Catalytic Triad and Oxyanion Hole in Acetylcholinesterase Catalysis: An ab initio QM/MM Study

Zhang, Y., Kua, J., & McCammon, J. A. (2002) · Journal of the American Chemical Society · doi:10.1021/ja020243m · Cited by 257 · see citing works

Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase involved in insecticide resistance

WALSH, S. B., DOLDEN, T. A., Moores, G. D., Kristensen, M., Lewis, T., DEVONSHIRE, A. L., & Williamson, M. S. (2001) · Biochemical Journal · doi:10.1042/bj3590175 · Cited by 249 · see citing works

Crystal structure of an acetylcholinesterase–fasciculin complex: interaction of a three-fingered toxin from snake venom with its target

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Natural Products and Derivatives Affecting Neurotransmission Relevant to Alzheimer’s and Parkinson’s Disease

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High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products

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Coumarins Isolated from Angelica gigas Inhibit Acetylcholinesterase: Structure−Activity Relationships

Kang, S. Y., Lee, K. Y., Sung, S. H., Park, M. J., & Kim, Y. C. (2001) · Journal of Natural Products · doi:10.1021/np000441w · Cited by 217 · see citing works

Huperzine A, A Potential Therapeutic Agent for Treatment of Alzheimer's Disease

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Acetylcholinesterase Inhibitory Activity of Scopolin and Scopoletin Discovered by Virtual Screening of Natural Products

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Inhibition of Acetylcholinesterase Activity by Bicyclic Monoterpenoids

Miyazawa, M., & Yamafuji, C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf040019b · Cited by 204 · see citing works

Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster populations

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Galantamine: Effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning

Woodruff‐Pak, D. S., Vogel, R. W., & Wenk, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2089 · Cited by 189 · see citing works

Qualitative determination of false‐positive effects in the acetylcholinesterase assay using thin layer chromatography

Rhee, I. K., van Rijn, R. M., & Verpoorte, R. (2003) · Phytochemical Analysis · doi:10.1002/pca.675 · Cited by 186 · see citing works

Functional Characteristics of the Oxyanion Hole in Human Acetylcholinesterase

Ordentlich, A., Barak, D., Kronman, C., Ariel, N., Segall, Y., Velan, B., & Avigdor Shafferman, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.31.19509 · Cited by 161 · see citing works

Acetylcholinesterase Enzyme Inhibitory Effects of Amaryllidaceae Alkaloids

Elgorashi, E. E., Stafford, G. I., & van Staden, J. (2004) · Planta Medica · doi:10.1055/s-2004-818919 · Cited by 160 · see citing works

Novel Diterpenoid Acetylcholinesterase Inhibitors fromSalvia miltiorhiza

Ren, Y., Houghton, P. J., Hider, R. C., & Howes, M. R. (2004) · Planta Medica · doi:10.1055/s-2004-815535 · Cited by 157 · see citing works

Novel Anticholinesterase and Antiamnesic Activities of Dehydroevodiamine, a Constituent ofEvodia rutaecarpa

Park, C., Kim, S., Choi, W., Lee, Y. J., Kim, J., Kang, S. S., & Sun, Y. (1996) · Planta Medica · doi:10.1055/s-2006-957926 · Cited by 143 · see citing works

Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants

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Naringenin from Citrus junos Has an Inhibitory Effect on Acetylcholinesterase and a Mitigating Effect on Amnesia

Heo, H. J., Kim, M., Lee, J., Choi, S. J., Cho, H., Hong, B.-S., Kim, H. K., Kim, E., & Shin, D.-H. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000076349 · Cited by 131 · see citing works

Cholinergic activity and amyloid precursor protein metabolism

Roberson, M. R. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00016-7 · Cited by 127 · see citing works

Inhibitory Effect of Ursolic Acid Purified from Origanum majorana L. on the Acetylcholinesterase

Chung, Y.-K., Heo, H. J., Kim, E.-K., Kim, H.-K., Huh, T., Lim, Y., Kim, S.-K., & Shin, D.-H. (2001) · Molecules and Cells · doi:10.1016/s1016-8478(23)17016-6 · Cited by 121 · see citing works

Indole alkaloids from Tabernaemontana australis (Müell. Arg) Miers that inhibit acetylcholinesterase enzyme

Andrade, M. T., Lima, J. A., Pinto, A. C., Rezende, C. M., Carvalho, M. P., & Epifanio, R. D. A. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.03.045 · Cited by 117 · see citing works

Medicinal Plants and Alzheimer's Disease: Integrating Ethnobotanical and Contemporary Scientific Evidence

Perry, E. K., Pickering, A. T., Wang, W. W., Houghton, P., & Perry, N. S. L. (1998) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.1998.4.419 · Cited by 113 · see citing works

Cholinesterase Inhibiting Withanolides from Withania somnifera

Choudhary, M. I., Sammer Yousuf, B., Nawaz, S. A., Ahmed, S., & Rahman, A. (2004) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.52.1358 · Cited by 113 · see citing works

Effects of glycowithanolides from <i>Withania somnifera</i> on an animal model of Alzheimer's disease and perturbed central cholinergic markers of cognition in rats

Bhattacharya, S. K., Kumar, A., & Ghosal, S. (1995) · Phytotherapy Research · doi:10.1002/ptr.2650090206 · Cited by 112 · see citing works

Acetylcholinesterase: A Multifaceted Target for Structure-Based Drug Design of Anticholinesterase Agents for the Treatment of Alzheimer's Disease

Greenblatt, H. M., Dvir, H., Silman, I., & Sussman, J. L. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:20:3:369 · Cited by 112 · see citing works

Inhibition of acetylcholinesterases by pulegone-1,2-epoxide

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Juliflorine: A potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential, a leading candidate for Alzheimer’s disease therapy

Choudhary, M. I., Nawaz, S. A., Ul‐Haq, Z., Azim, M. K., Ghayur, M. N., Lodhi, M. A., Jalil, S., Khalid, A., Ahmed, A., Rode, B. M., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.05.068 · Cited by 102 · see citing works

Activities of the enantiomers of cocaine and some related compounds as substrates and inhibitors of plasma butyrylcholinesterase

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Choline esterase inhibitory properties of alkaloids from two Nigerian Crinum species

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Arisugacin, a Novel and Selective Inhibitor of Acetylcholinesterase from Penicillium sp. FO-4259.

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Protopine from Corydalis ternata has Anticholinesterase and Antiamnesic Activities

Kim, S. R., Hwang, S. Y., Jang, Y. P., Park, M. J., Markelonis, G. J., Oh, T. H., & Kim, Y. C. (1999) · Planta Medica · doi:10.1055/s-1999-13983 · Cited by 96 · see citing works

Sieboldine A, a Novel Tetracyclic Alkaloid from Lycopodium sieboldii, Inhibiting Acetylcholinesterase

Hirasawa, Y., Morita, H., Shiro, M., & Kobayashi, J. (2003) · Organic Letters · doi:10.1021/ol035560s · Cited by 96 · see citing works

Neurotoxicity of acetylcholinesterase amyloid β‐peptide aggregates is dependent on the type of Aβ peptide and the AChE concentration present in the complexes

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Arisugacins, selective acetylcholinesterase inhibitors of microbial origin

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Effects of Green Tea Polyphenol on Cognitive and Acetylcholinesterase Activities

Kim, H. K., Kim, M., Kim, S., Kim, M., & Chung, J. H. (2004) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.68.1977 · Cited by 87 · see citing works

Studies in the Indole Series. V. The Complete Synthesis of Physostigmine (Eserine)

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Acetyl and butyrylcholinesterase-inhibiting triterpenoid alkaloids from Buxus papillosa

Rahman, A., Parveen, S., Khalid, A., Farooq, A., & Choudhary, M. I. (2001) · Phytochemistry · doi:10.1016/s0031-9422(01)00332-6 · Cited by 86 · see citing works

Cloning and Expression of Acetylcholinesterase from Venom

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Old Chinese Herbal Medicine Used for Fever Yields Possible New Alzheimer Disease Therapy

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Insecticidal Effect of Phthalides and Furanocoumarins from Angelica acutiloba against Drosophila melanogaster

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Immunopathogenesis of Psoriasis

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Screening of Non‐Alkaloidal Natural Compounds as Acetylcholinesterase Inhibitors

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Arisugacins A and B, Novel and Selective Acetylcholinesterase Inhibitors from Penicillium sp. FO-4259. I. Screening, Taxonomy, Fermentation, Isolation and Biological Activity.

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Acetylcholinesterase inhibitors from the aerial parts ofCorydalis speciosa

Kim, D. K., Lee, K. T., Baek, N., Kim, S., Park, H. W., Lim, J., Shin, T. Y., Eom, D. O., Yang, J. H., & Eun, J. S. (2004) · Archives of Pharmacal Research · doi:10.1007/bf02975117 · Cited by 75 · see citing works

Xanthones fromGentiana campestrisas New Acetylcholinesterase Inhibitors

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Acetylcholinesterase inhibitors from the twigs ofvaccinium oldhami miquel

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(+)-.ALPHA.-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase.

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Kinetics of human acetylcholinesterase inhibition by the novel experimental alzheimer therapeutic agent, tolserine

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Presence of Antispasmodic, Antidiarrheal, Antisecretory, Calcium Antagonist and Acetylcholinesterase Inhibitory Steroidal Alkaloids inSarcococca saligna

Gilani, A. H., Ghayur, M. N., Khalid, A., Ul‐Haq, Z., Choudhary, M. I., & Rahman, A. (2005) · Planta Medica · doi:10.1055/s-2005-837777 · Cited by 69 · see citing works

Effect of Long-Term Administration of Berberine on Scopolamine Induced Amnesia in Rats.

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Quinolactacins A1 and A2, New Acetylcholinesterase Inhibitors from Penicillium citrinum.

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Bioactive Metabolites from the Fungus Nectria galligena , the Main Apple Canker Agent in Chile

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Differential effects of "peripheral" site ligands on Torpedo and chicken acetylcholinesterase.

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RUPTURE OF INTERSTITIAL TUBAL PREGNANCY: HYSTERECTOMY

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Cyclophostin, acetylocholinesterase inhibitor from Streptomyces lavendulae.

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Kinetics and structure–activity relationship studies on pregnane-type steroidal alkaloids that inhibit cholinesterases

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Cholinesterase inhibitory and spasmolytic potential of steroidal alkaloids

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Acetylcholinesterase inhibitors from the roots ofangelica dahurica

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The Application of HPLC with On-Line Coupled UV/MS−Biochemical Detection for Isolation of an Acetylcholinesterase Inhibitor from Narcissus ‘Sir Winston Churchill'

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Insecticidal organophosphates: Nature made them first

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Studying the roles of W86, E202, and Y337 in binding of acetylcholine to acetylcholinesterase using a combined molecular dynamics and multiple docking approach

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Inhibition of insect acetylcholinesterase by the potato glycoalkaloid α‐chaconine

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The TREATMENT of DIPHTHERIA

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Acetylcholinesterase and Insect Growth Inhibitory Activities of Gutierrezia microcephala on Fall Army worm Spodoptera frugiperda J. E. Smith

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Cholinesterase Inhibitory Constituents from Onosma hispida

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New Cholinesterase Inhibiting Steroidal Alkaloids from the Leaves of Sarcococca coriacea of Nepalese Origin.

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Inhibitory effect ofTrans-N-p-coumaroyl tryamine from the twigs ofCeltis chinensis on the acetylcholinesterase

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New Triterpenoid Alkaloid Cholinesterase Inhibitors from Buxus hyrcana

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Honokiol and Magnolol Increased Hippocampal Acetylcholine Release in Freely-Moving Rats

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