The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Muscle Impairments in Patients With Knee Osteoarthritis
Open accessAbstract
CONTEXT: Muscle impairments associated with knee osteoarthritis (OA) are the primary underlying cause of functional limitations. Understanding the extent of muscle impairments, its relationship with physical function and disease progression, and the evidence behind exercise therapy that targets muscle impairments is crucial. EVIDENCE ACQUISITION: An electronic search for relevant articles using MEDLINE and CINHAL databases up to September 2011 was performed. In addition to the electronic search, retrieved articles were searched manually for relevant studies. RESULTS: Quadriceps, hamstrings, and hip muscles are significantly impaired in subjects with knee OA compared with age-matched controls. Muscle strength, especially quadriceps, is a major determinant of both performance-based and self-reported physical function. Whether stronger quadriceps is protective against knee OA onset and progression is not clear. Exercise therapy, including global and targeted resistance training, is effective in reducing pain and improving function in subjects with knee OA. CONCLUSIONS: Subjects with knee OA have significant muscle impairments. These muscle impairments affect physical function and should be targeted in therapy. Further research is needed to explore the relationship between quadriceps strength and knee OA initiation and progression and to determine the optimal exercise prescription that augments outcomes in this patient population.
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“Additionally, a wider stance during squatting reduces lumbar loading26 and permits a more upright lumbar (less kyphosis).60”
From A Biomechanical Review of the Squat Exercise: Implications for Clinical Practice. (2024) · cites this paper as [60]
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Zhang, W., Moskowitz, R. W., Nuki, G., Abramson, S., Altman, R. D., Arden, N., Bierma-Zeinstra, S., Brandt, K. D., Croft, P., Doherty, M., et al. (2008) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.12.013 · Cited by 2,796
Jordan, K. M., Arden, N. K., Doherty, M., Bannwarth, B., Bijlsma, J. W. J., Dieppe, P. A., Gunther, K., Häuselmann, H., Herrero‐Beaumont, G., Kaklamanis, P., et al. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.011742 · Cited by 2,036
OARSI recommendations for the management of hip and knee osteoarthritis
Zhang, W., Nuki, G., Moskowitz, R. W., Abramson, S. B., Altman, R. D., Arden, N., Bierma‐Zeinstra, S., Brandt, K. D., Croft, P. R., Doherty, M., et al. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.01.013 · Cited by 1,726
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Quadriceps Weakness and Osteoarthritis of the Knee
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Cited by
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Primorac, D., Molnar, V., Rod, E., Jeleč, Ž., Čukelj, F., Matišić, V., Vrdoljak, T., Hudetz, D., Hajsok, H., & Borić, I. (2020) · Genes · doi:10.3390/genes11080854 · Cited by 636
Grimmer, M., Riener, R., Walsh, C. J., & Seyfarth, A. (2019) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-018-0458-8 · Cited by 249
Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis
Kim, J., Yoo, J. J., & Kim, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030674 · Cited by 139
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Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems
Ma, L., Zheng, X., Lin, R., Sun, A. R., Song, J., Ye, Z., Liang, D., Zhang, M., Tian, J. H., Zhou, X., et al. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s357386 · Cited by 86
Metadata
- Authors
- Alnahdi, A. H., Zeni, J. A., & Snyder-Mackler, L.
- Affiliations
- King Saud University (SA)
- University of Delaware (US)
- Department of Physical Therapy, University of Delaware, Newark, Delaware
- Venue
- Sports Health A Multidisciplinary Approach
- Publisher
- SAGE Publications
- Published
- 2012-06-19
- Volume
- 4
- Issue
- 4
- Pages
- 284-292
- ISSN
- 1941-0921 (ISSN-L)
- 1941-7381
- PMC
- PMC3435919
- OpenAlex
- W2101943922
- Cited by
- 233
- References
- 75
- Citations by year
- 2026: 19 · 2025: 25 · 2024: 29 · 2023: 29 · 2022: 26 · 2021: 13 · 2020: 18 · 2019: 13 · 2018: 14 · 2017: 14 · 2016: 14 · 2015: 8 · 2014: 9 · 2013: 2
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Sports Health A Multidisciplinary Approach (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Physical Sciences › Engineering › Biomedical Engineering › Lower Extremity Biomechanics and Pathologies
- Keywords
- knee osteoarthritis, muscle impairment, quadriceps strength, hamstrings, hip muscle strength, physical function, resistance training, exercise therapy, disease progression, analgesia
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