Cited by 233Osteoarthritis Treatment and MechanismsMusculoskeletal pain and rehabilitationLower Extremity Biomechanics and Pathologies

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Muscle Impairments in Patients With Knee Osteoarthritis

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Alnahdi, Ali H., Zeni, Joseph A., Snyder-Mackler, Lynn·2012·Sports Health A Multidisciplinary Approach

DOI 10.1177/1941738112445726PMC PMC3435919

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Abstract

CONTEXT: Muscle impairments associated with knee osteoarthritis (OA) are the primary underlying cause of functional limitations. Understanding the extent of muscle impairments, its relationship with physical function and disease progression, and the evidence behind exercise therapy that targets muscle impairments is crucial. EVIDENCE ACQUISITION: An electronic search for relevant articles using MEDLINE and CINHAL databases up to September 2011 was performed. In addition to the electronic search, retrieved articles were searched manually for relevant studies. RESULTS: Quadriceps, hamstrings, and hip muscles are significantly impaired in subjects with knee OA compared with age-matched controls. Muscle strength, especially quadriceps, is a major determinant of both performance-based and self-reported physical function. Whether stronger quadriceps is protective against knee OA onset and progression is not clear. Exercise therapy, including global and targeted resistance training, is effective in reducing pain and improving function in subjects with knee OA. CONCLUSIONS: Subjects with knee OA have significant muscle impairments. These muscle impairments affect physical function and should be targeted in therapy. Further research is needed to explore the relationship between quadriceps strength and knee OA initiation and progression and to determine the optimal exercise prescription that augments outcomes in this patient population.

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Authors: Alnahdi, A. H., Zeni, J. A., & Snyder-Mackler, L.
Affiliations: King Saud University (SA)
University of Delaware (US)
Department of Physical Therapy, University of Delaware, Newark, Delaware
ORCID: Alnahdi, Ali H.
Zeni, Joseph A.
Venue: Sports Health A Multidisciplinary Approach
Publisher: SAGE Publications
Published: 2012-06-19
Volume: 4
Issue: 4
Pages: 284-292
ISSN: 1941-0921 (ISSN-L)
1941-7381
DOI: 10.1177/1941738112445726
PMC: PMC3435919
OpenAlex: W2101943922
Cited by: 233
References: 75
Citations by year: 2026: 19 · 2025: 25 · 2024: 29 · 2023: 29 · 2022: 26 · 2021: 13 · 2020: 18 · 2019: 13 · 2018: 14 · 2017: 14 · 2016: 14 · 2015: 8 · 2014: 9 · 2013: 2
FWCI: 4.67
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Sports Health A Multidisciplinary Approach (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Physical Sciences › Engineering › Biomedical Engineering › Lower Extremity Biomechanics and Pathologies
Keywords: knee osteoarthritis, muscle impairment, quadriceps strength, hamstrings, hip muscle strength, physical function, resistance training, exercise therapy, disease progression, analgesia

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Muscle Impairments in Patients With Knee Osteoarthritis

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