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Cited by 32Osteoarthritis Treatment and MechanismsMesenchymal stem cell researchPeriodontal Regeneration and Treatments

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Efficacy and Safety of Intra-Articular Cell-Based Therapy for Osteoarthritis: Systematic Review and Network Meta-Analysis

Open access
Ding, Wei, Xu, Yong-qing, Zhang, Ying, Li, An-xu, Qiu, Xiong, Wen, Hong-jie, Tan, Hong-bo·2021·CARTILAGE
DOI 10.1177/1947603520942947PMC PMC8808819
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Abstract

Objective: Osteoarthritis (OA) is a chronic joint disease characterized by degeneration of articular cartilage and secondary osteogenesis. Cell-based agents, such as mesenchymal stem cells, have turned into the most extensively explored new therapeutic agents for OA. However, evidence-based research is still lacking. Methods: We searched public databases up to February 2020 and only included randomized controlled trials. The outcomes included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Knee Injury and Osteoarthritis Outcome Score (KOOS), the visual analogue scale (VAS) score, and serious adverse events (SAEs). A network meta-analysis was also performed in this work. Results: We included 13 studies in the meta-analysis. The effect size showed that cell-based therapy did not significantly reduce the WOMAC score at the 6-month follow-up (standard mean difference [SMD] −3.6; 95% confidence interval [CI] −0.90 to 0.18; P = 0.1928). However, cell-based therapy significantly improved the KOOS at the 12-month follow-up (SMD 0.68; 95% CI 0.07-1.30; P = 0.0288) and relieved pain (SMD −1.05; 95% CI −1.46 to −0.64; P < 0.0001). The findings also indicated that high-dosage adipose-derived mesenchymal stem cells (ADMSCs) may be more advantageous in terms of long-term effects. Conclusions: Cell-based therapy had a better effect on KOOS improvement and pain relief without safety concerns. However, cell-based therapy did not show a benefit in terms of the WOMAC. Allogeneic cells might have advantages compared to controls in the WOMAC and KOOS scores. The long-term effect of high-dose ADMSC treatment for OA is worthy of further study.

Overview

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Crossref · 10.1177/1947603520942947

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46 of 46 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Ding, W., Xu, Y.-Q., Zhang, Y., Li, A.-X., Qiu, X., Wen, H.-J., & Tan, H.-B.
Affiliations
  • Medical College, Yunnan University of Business Management, Kunming, Yunnan, People’s Repuplic of China
  • Department of Orthopaedic, The 920th Hospital of Joint Logistics Support Force, Kunming, Yunnan, People’s Republic of China
  • Department of Orthopedic Surgery, The Fourth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, Peoples’ Republic of China
ORCID
Venue
CARTILAGE
Publisher
SAGE Publications
Published
2020-07-22
Volume
13
Issue
1_suppl
Pages
104S-115S
ISSN
  • 1947-6035 (ISSN-L)
  • 1947-6043
DOI
10.1177/1947603520942947
PMC
PMC8808819
OpenAlex
W3045260871
Cited by
32
References
46
Citations by year
2026: 2 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 4
FWCI
0.70
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Cartilage (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
national basic research program of china (2017YFC1103904, 2018HB001)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Keywords
osteoarthritis, mesenchymal stem cells, adipose-derived stem cells, allogeneic cells, WOMAC, KOOS, analgesia, treatment efficacy, safety, dose comparison
MeSH terms
Network Meta-Analysis, Humans, Injections, Intra-Articular, Regeneration, Transplantation, Autologous, Treatment Outcome, Osteoarthritis, Knee, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.