The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Adipose-Derived Mesenchymal Stem Cell Therapy in the Treatment of Knee Osteoarthritis: A Randomized Controlled Trial
Open accessAbstract
Aim: To evaluate the efficacy of autologous adipose-derived mesenchymal stem cell (ADMSC) therapy on pain, function and disease modification in knee osteoarthritis. Methods: 30 participants with symptomatic knee osteoarthritis were randomized into three groups. Two treatment groups received intra-articular ADMSC therapy consisting of either a single injection (100 × 106 ADMSCs) or two injections (100 × 106 ADMSCs at baseline and 6 months). The third group served as control and continued conservative management. Results: No serious adverse events were observed. Both treatment groups receiving ADMSCs showed clinically significant pain and functional improvement at completion of follow-up at 12 months. Radiological analysis using the Magnetic Resonance Imaging Osteoarthritis Knee Score indicated modification of disease progression. Conclusion: Autologous ADMSC therapy appears to be a safe and effective therapy for knee osteoarthritis and may have the potential to prevent disease progression. Trial registration number: ACTRN12614000814673
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Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766
Core outcome measures for chronic pain clinical trials: IMMPACT recommendations
Dworkin, R. H., Turk, D. C., Farrar, J. T., Haythornthwaite, J. A., Jensen, M. P., Katz, N. P., Kerns, R. D., Stucki, G., Allen, R. R., Bellamy, N., et al. (2005) · Pain · doi:10.1016/j.pain.2004.09.012 · Cited by 3,732
Loeser, R. F. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.03.002 · Cited by 726
Recommendations for Planning Pilot Studies in Clinical and Translational Research
Moore, C. G., Carter, R. E., Nietert, P. J., & Stewart, P. W. (2011) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2011.00347.x · Cited by 661 · cited 1×
“This study represents a pilot RCT to assess treatment protocols for safety and efficacy prior to development of a larger RCT and is consistent with previously published study guidelines [50].”
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Cited by
Chen, X., Zheng, J., Yin, L., Li, Y., & Liu, H. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-04846-1 · Cited by 34
Ding, W., Xu, Y.-Q., Zhang, Y., Li, A.-X., Qiu, X., Wen, H.-J., & Tan, H.-B. (2021) · CARTILAGE · doi:10.1177/1947603520942947 · Cited by 32
Yan, L., Li, D., Li, S., Jiao Li, J., Du, G., Liu, H., Zhang, J., Li, X., Fan, Z., Jiu, J., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.154432 · Cited by 20
Metadata
- Authors
- Freitag, J., Bates, D., Wickham, J., Shah, K., Huguenin, L., Tenen, A., Paterson, K., & Boyd, R.
- Venue
- Regenerative Medicine
- Publisher
- Informa UK Limited
- Published
- 2019-02-14
- Volume
- 14
- Issue
- 3
- Pages
- 213-230
- ISSN
- 1746-0751 (ISSN-L)
- 1746-076X
- OpenAlex
- W2912040253
- Cited by
- 367
- References
- 4
- FWCI
- 29.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Adipose-Derived Mesenchymal Stem Cell Therapy in the Treatment of Knee Osteoarthritis: A Randomized Controlled Trial. https://app.cochat.ai/papers/10.2217/rme-2018-0161
- The paper
- Freitag, J., Bates, D., Wickham, J., Shah, K., Huguenin, L., Tenen, A., Paterson, K., & Boyd, R. (2019). Adipose-Derived Mesenchymal Stem Cell Therapy in the Treatment of Knee Osteoarthritis: A Randomized Controlled Trial. Regenerative Medicine. https://doi.org/10.2217/rme-2018-0161
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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