The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.
Naloxone dosage for opioid reversal: current evidence and clinical implications
Open accessAbstract
Opioid-related mortality is a growing problem in the United States, and in 2015 there were over 33,000 opioid-related deaths. To combat this mortality trend, naloxone is increasingly being utilized in a pre-hospital setting by emergency personnel and prescribed to laypersons for out-of-hospital administration. With increased utilization of naloxone there has been a subsequent reduction in mortality following an opioid overdose. Reversal of opioid toxicity may precipitate an opioid-withdrawal syndrome. At the same time, there is a risk of inadequate response or re-narcotization after the administration of a single dose of naloxone in patients who have taken large doses or long-acting opioid formulations, as the duration of effect of naloxone is shorter than that of many opioid agonists. As out-of-hospital use of this medication is growing, so too is concern about effective but safe dosing.
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Cites
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Cited by
Treatment of opioid overdose: current approaches and recent advances
Britch, S. C., & Walsh, S. L. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06125-5 · Cited by 96
Pharmacologic Treatment of Opioid Use Disorder: a Review of Pharmacotherapy, Adjuncts, and Toxicity
Toce, M. S., Chai, P. R., Burns, M. M., & Boyer, E. W. (2018) · Journal of Medical Toxicology · doi:10.1007/s13181-018-0685-1 · Cited by 90
Clinical Pharmacokinetics and Pharmacodynamics of Naloxone
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Self-citationVandeputte, M. M., Tsai, M.-H. M., Chen, L., Glatfelter, G. C., Walther, D., Stove, C. P., Shi, L., & Baumann, M. H. (2023) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2023.109939 · Cited by 39
Metadata
- Authors
- Rzasa Lynn, R., & Galinkin, J.
- Venue
- Therapeutic Advances in Drug Safety
- Publisher
- SAGE Publications
- Published
- 2017-12-13
- Volume
- 9
- Issue
- 1
- Pages
- 63-88
- ISSN
- 2042-0986 (ISSN-L)
- 2042-0994
- OpenAlex
- W2771307521
- Cited by
- 346
- References
- 152
- FWCI
- 21.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
