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Cited by 323Health disparities and outcomesCardiac Health and Mental HealthCardiovascular Health and Risk Factors

The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.

Loneliness, social isolation and risk of cardiovascular disease in the English Longitudinal Study of Ageing

Open access
Valtorta, Nicole K, Kanaan, Mona, Gilbody, Simon, Hanratty, Barbara·2018·European Journal of Preventive Cardiology
DOI 10.1177/2047487318792696
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Abstract

Background: There is increasing evidence of an association between social relationships and morbidity in general, and cardiovascular disease in particular. However, recent syntheses of the evidence raise two important questions: is it the perceived quality or the more objective quantity of relationships that matters most; and what are the implications of changes in relationships over time? In this study, we investigate the cumulative effects of loneliness and social isolation on incident cardiovascular disease. Design: A secondary analysis of prospective follow-up data from the English Longitudinal Study of Ageing (ELSA). Methods: To assess the association between social isolation or loneliness and incident cardiovascular disease, lagged values of exposure to loneliness and isolation were treated as time-varying variables in discrete time survival models controlling for potential confounders and established cardiovascular disease risk factors. Results: A total of 5397 men and women aged over 50 years were followed up for new fatal and non-fatal diagnoses of heart disease and stroke between 2004 and 2010. Over a mean follow-up period of 5.4 years, 571 new cardiovascular events were recorded. We found that loneliness was associated with an increased risk of cardiovascular disease (odds ratio 1.27, 95% confidence interval 1.01–1.57). Social isolation, meanwhile, was not associated with disease incidence. There was no evidence of a cumulative effect over time of social relationships on cardiovascular disease risk. Conclusions: Loneliness is associated with an increased risk of developing coronary heart disease and stroke, independently of traditional cardiovascular disease risk factors. Our findings suggest that primary prevention strategies targeting loneliness could help to prevent cardiovascular disease.

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Crossref · 10.1177/2047487318792696

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Research works printed but not linked: 5

  1. Taylor R, 2007, Health, wealth and lifestyles of the older population in England: the 2002 English Longitudinal Study of Ageing – technical report, wave 1
  2. Pinquart M, 2003, Adv Psychol Res, 19, 111
  3. Phillips D, 2016, In: Program on Aging, Health and Policy
  4. StataCorp, 2011, Stata statistical software: release 14.2
  5. Beach B, 2016, Isolation: the emerging crisis for older men

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Metadata

Authors
Valtorta, N. K., Kanaan, M., Gilbody, S., & Hanratty, B.
Affiliations
  • Newcastle University (GB)
  • University of York (GB)
ORCID
Venue
European Journal of Preventive Cardiology
Publisher
Oxford University Press (OUP)
Published
2018-08-02
Volume
25
Issue
13
Pages
1387-1396
ISSN
  • 2047-4873 (ISSN-L)
  • 2047-4881
DOI
10.1177/2047487318792696
OpenAlex
W2887028845
Cited by
323
References
38
Citations by year
2026: 39 · 2025: 53 · 2024: 52 · 2023: 45 · 2022: 41 · 2021: 44 · 2020: 33 · 2019: 14 · 2018: 1
FWCI
3.81
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • European Journal of Preventive Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (submittedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Funders
National Institute for Health and Care Research (DRF-2013-06-074)
Topics
  • Social Sciences › Health › Health disparities and outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords
loneliness, social isolation, cardiovascular disease, stroke, coronary artery disease, interpersonal relationships, older adults, cardiovascular risk factors, primary prevention
MeSH terms
Aged, Aging, Cardiovascular Diseases, Humans, Loneliness, Risk Factors, Social Isolation, Global Health, Incidence

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