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Cited by 6Renal Diseases and GlomerulopathiesChronic Kidney Disease and DiabetesRenal and Vascular Pathologies

Lipoprotein Glomerulopathy in a Hispanic Female: A Case Report and Literature Review

Open access
Majeed, Nasma K., McLaughlin, Jeanette, Gonzalez, Miguel·2019·Canadian Journal of Kidney Health and Disease
DOI 10.1177/2054358119859576PMC PMC6600489
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Abstract

Rationale: Lipoprotein glomerulopathy (LPG) is a rare renal disorder that features glomerular capillary lipoprotein thrombi, proteinuria, and progressive renal failure. Although most reported cases describe involvement in Asian patients, occurrence in Caucasian and other ethnicities has also been reported. Presenting concern: A 28-year-old Hispanic female with a past medical history of hypertension, high cholesterol, gastritis, and a strong family history of renal disease presented with abdominal pain. On admission, her blood pressure was elevated. A computed tomography scan was unremarkable. Her laboratory studies showed proteinuria, high creatinine level, and an abnormal lipid profile. Diagnosis: The kidney biopsy showed glomerular capillary lipoprotein thrombi that stained positively for Oil-Red-O, confirming the lipid nature of the material consistent with LPG. Intervention: After stabilizing her blood pressure, the patient was started on fenofibrate to treat her high cholesterol and improve her renal function. Outcome: Her lipid profile and renal function were initially improved. However, after one year of treatment, her renal function started to decline and the patient was referred to a transplant center for further management. Novel finding: To the best of our knowledge, this the first reported incidence of LPG in a Hispanic female.

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Crossref · 10.1177/2054358119859576

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  • Only 10 cases of LPG (including this one) have been reported from North America, and previously only 5 included gene sequencing.

    “Only 10 cases of LPG (including this one) have been reported from North America,2,18,21–26 and previously only 5 of these included gene sequencing: 3 APOE Kyoto,18,23 1 APOE Chicago,22 1 APOE Las Vegas.25”

    From Lipoprotein Glomerulopathy, First Case Report from Canada (2022) · cites this paper as [2]

    Table 1 in the Discussion lists North American cases with APOE Kyoto, Chicago, and Las Vegas findings, supporting the claim’s general account of prior genetic testing. It lists two Kyoto cases, however, not three. The Discussion gives approximately 13 non-Asian cases worldwide, not a total of 10 North American cases or five previously sequenced North American cases. (LLM, conf=0.86)

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  • Approximately 200 cases of LPG have been reported, mostly from China and Japan, with only a handful outside Asia.

    “Since then, approximately 200 cases have been reported, mostly from China and Japan, with only a handful of cases reported outside of Asia.2”

    From Lipoprotein Glomerulopathy, First Case Report from Canada (2022) · cites this paper as [2]

    The Discussion reports more than 150 cases, not approximately 200, so it does not establish the claimed total. It supports that most cases were from Japan and China, but its figure of approximately 13 refers to non-Asian patients, not strictly to cases reported outside Asia. (LLM, conf=0.86)

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Cites

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Research works printed but not linked: 17

  1. [1]Meyrier A Dairou F Callard P Mougenot B. Lipoprotein glomerulopathy: first case in a white European. Nephrol Dial Transplant. 1995; 10(4): 546- 549. 7624001
  2. [2]Saito T Ishigaki Y Oikawa S Yamamoto TT. Etiological significance of apolipoprotein E mutations in lipoprotein glomerulopathy. Trends Cardiovasc Med. 2002; 12(2): 67- 70. 11852253
  3. [3]Faraggiana T Churg J. Renal lipidoses: a review. Hum Pathol. 1987; 18(7): 661- 679. 3297993
  4. [5]Mourad G Djamali A Turc-Baron C Cristol JP. Lipoprotein glomerulopathy: a new cause of nephrotic syndrome after renal transplantation. Nephrol Dial Transplant. 1998; 13(5): 1292- 1294. 9623574
  5. [6]Rovin BH Roncone D McKinley A Nadasdy T Korbet SM Schwartz MM. APOE Kyoto mutation in European Americans with lipoprotein glomerulopathy. N Engl J Med. 2007; 357(24): 2522- 2524. 18077821
  6. [7]Bomback AS Song H D’Agati VD et al A new apolipoprotein E mutation, apoE Las Vegas, in a European-American with lipoprotein glomerulopathy. Nephrol Dial Transplant. 2010; 25(10): 3442- 3446. 20624773
  7. [8]Boumendjel R Papari M Gonzalez M. A rare case of lipoprotein glomerulopathy in a white man: an emerging entity in Asia, rare in the white population. Arch Pathol Lab Med. 2010; 134(2): 279- 282. 20121619
  8. [9]Pasquariello A Pasquariello G Innocenti M et al Lipoprotein glomerulopathy: first report of 2 not consanguineous Italian men from the same town. J Nephrol. 2011; 24(3): 381- 385. 21534236
  9. [10]Magistroni R Bertolotti M Furci L et al Lipoprotein glomerulopathy associated with a mutation in apolipoprotein E. Clin Med Insights Case Rep. 2013; 6: 189- 196. 24348079 PMC3859823
  10. [11]Sipovskii VG Klemina IK Zverkov RV Dobronravov VA Smirnov AV. A case of diagnosing lipoprotein glomerulopathy in Russia. Arkh Patol. 2016; 78(6): 52- 57. 28139603
  11. [12]Sethi S. The Case|Renal failure with intracapillary thrombi. Kidney Int. 2008; 73(9): 1097- 1098. 18414445
  12. [13]Pêgas KL Rohde R Garcia CD et al Lipoprotein glomerulopathy: a case report of a rare disease in a Brazilian child. J Bras Nefrol. 2014; 36(1): 93- 95. 24676620
  13. [14]Sam R Wu H Yue L et al Lipoprotein glomerulopathy: a new apolipoprotein E mutation with enhanced glomerular binding. Am J Kidney Dis. 2006; 47(3): 539- 548. 16490634
  14. [15]Saito T Matsunaga A. Lipoprotein glomerulopathy may provide a key to unlock the puzzles of renal lipidosis. Kidney Int. 2014; 85(2): 243- 245. 24487366
  15. [16]Chen S Liu ZH Zheng JM Zhang X Li LS. A complete genomic analysis of the apolipoprotein E gene in Chinese patients with lipoprotein glomerulopathy. J Nephrol. 2007; 20: 568- 575. 17918142
  16. [19]Matsunaga A Furuyama M Hashimoto T Toyoda K Ogino D Hayasaka K. Improvement of nephrotic syndrome by intensive lipid-lowering therapy in a patient with lipoprotein glomerulopathy. Clin Exp Nephrol. 2009; 13(6): 659- 662. 19603250
  17. [20]Cheung CY Chan AO Chan GP Iu HY Shek CC Chau KF. Long-term outcome of kidney transplantation in a patient with coexisting lipoprotein glomerulopathy and fibrillary glomerulonephritis. Clin Kidney J. 2014; 7(4): 396- 398. 25852917 PMC4377804

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Authors
Majeed, N. K., McLaughlin, J., & Gonzalez, M.
Affiliations
  • University of Illinois Chicago (US)
  • Advocate Christ Medical Center (US)
  • Advocate Lutheran General Hospital (US)
Corresponding author
Majeed, Nasma K.
ORCID
Majeed, Nasma K.
Venue
Canadian Journal of Kidney Health and Disease
Publisher
SAGE Publications
Published
2019-01
Volume
6
Pages
2054358119859576-2054358119859576
ISSN
2054-3581 (ISSN-L)
DOI
10.1177/2054358119859576
PMC
PMC6600489
OpenAlex
W2956056382
Cited by
6
References
3
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 1
FWCI
0.58
Type
journal article
Language
en
Open access
Licence
Locations
  • Canadian Journal of Kidney Health and Disease (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
Keywords
lipoprotein glomerulopathy, proteinuria, renal failure, Hispanic patients, renal biopsy, Oil Red O staining, fenofibrate, hypercholesterolemia, kidney transplantation

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