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PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY
Abstract
A new fixative which primarily stabilizes carbohydrate moieties was developed for immunoelectron microscopy. It contains periodate, lysine and paraformaldehyde. Theoretically, the carbohydrates are oxidized by periodate and cross-linked by lysine. The fixative can preserve antigenicity as well as paraformaldehyde and ultrastructure as well as glutaraldehyde. Using this fixative and the peroxidase-labeled antibody technique, basement membrane antigen was localized within the cisternae of endoplasmic reticulum of parietal yolk sac cells and in extracellular basement membranes with adequate tissue preservation, a task which has not been successfully accomplished by conventional fixatives.
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Cited by
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Metadata
- Authors
- MCLEAN, I. W., & NAKANE, P. K.
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 1974-12
- Volume
- 22
- Issue
- 12
- Pages
- 1077-1083
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W2164620775
- Cited by
- 3,798
- References
- 0
- FWCI
- 14.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY. https://app.cochat.ai/papers/10.1177/22.12.1077
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- MCLEAN, I. W., & NAKANE, P. K. (1974). PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY. Journal of Histochemistry & Cytochemistry. https://doi.org/10.1177/22.12.1077
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
