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Cited by 9

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Minocycline-loaded calcium polyphosphate glass microspheres as a potential drug-delivery agent for the treatment of periodontitis

Gibson, Iain, Momeni, Arash, Filiaggi, Mark·2019·Journal of Applied Biomaterials & Functional Materials
DOI 10.1177/2280800019863637
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Abstract

Background: Periodontitis is an inflammatory disease with a bacterial etiology that affects the supporting structures of the teeth and is a major cause of tooth loss. The objective of this study was to investigate the drug loading and in vitro release of minocycline from novel calcium polyphosphate microspheres intended for use in treating periodontitis. Methods: Calcium polyphosphate coacervate, produced by a precipitation reaction of calcium chloride and sodium polyphosphate solutions, was loaded with minocycline and subsequently used to produce microspheres by an emulsion/solvent extraction technique. Microspheres classified by size were subjected to a 7-day elution in a Tris-buffer solution under dynamic conditions. The physicochemical characteristics of the drug-loaded microspheres were investigated using scanning electron microscopy, particle size analysis, Phosphorus-31 Nuclear Magnetic Resonance spectroscopy, and Inductively Coupled Plasma Optical Emission Spectroscopy. Drug loading and release were determined using ultraviolet -visible (UV/VIS) spectrophotometry. Results: Minocycline-loaded calcium polyphosphate microspheres of varying size were successfully produced, with small and large microspheres having volume mean diameters of 22 ± 1 µm and 193 ± 5 µm, respectively. Polyphosphate chain length and calcium to phosphorus mole ratio remained stable throughout microsphere production. Drug loading was 1.64 ± 0.16, 1.35 ± 0.55, and 0.84 ± 0.14 weight% for the coacervate and large and small microspheres, respectively, corresponding to mean encapsulation efficiencies of 81.7 ± 12.2 % and 50.9 ± 3.9 % for the large and small microspheres. Sustained drug release was observed in vitro over a clinically relevant 7-day period, with small and large microspheres exhibiting similar elution profiles. Antibiotic release generally followed microsphere degradation as measured by Ca and P ion release. Conclusions: This study demonstrated successful drug loading of calcium polyphosphate microspheres with minocycline. Furthermore, in vitro sustained release of minocycline over a 7-day period was observed, suggesting potential utility of this approach for treating periodontitis.

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Metadata

Authors
Gibson, I., Momeni, A., & Filiaggi, M.
Affiliations
Faculty of Dentistry, Dalhousie University, Halifax, Canada
ORCID
Filiaggi, Mark
Venue
Journal of Applied Biomaterials & Functional Materials
Publisher
SAGE Publications
Published
2019-04
Volume
17
Issue
3
ISSN
2280-8000
DOI
10.1177/2280800019863637
Cited by
9
References
1
Language
en
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Funders
  • Natural Sciences and Engineering Research Council of Canada (Discovery Grant)
  • Faculty of Dentistry, Dalhousie University (Faculty Research Fund)
  • Springboard Atlantic (Innovation Mobilization Program)

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CoChat. (2026). Citation check: Minocycline-loaded calcium polyphosphate glass microspheres as a potential drug-delivery agent for the treatment of periodontitis. https://app.cochat.ai/papers/10.1177/2280800019863637
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Gibson, I., Momeni, A., & Filiaggi, M. (2019). Minocycline-loaded calcium polyphosphate glass microspheres as a potential drug-delivery agent for the treatment of periodontitis. Journal of Applied Biomaterials & Functional Materials. https://doi.org/10.1177/2280800019863637

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