The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Efficacy and Safety of a Colic Relief Remedy in Infantile Colic
Abstract
Infantile colic is the most frequent reason of infant and parental distress. An open-label single-group clinical study was conducted primarily to evaluate the effect of 14-day colic relief remedy administration (1.25 ml orally during colic episode) on average daily crying time in infants compared to baseline. In addition, the percentage of responders, sleep pattern, frequency and severity of gastrointestinal symptoms, tolerability of the product and percentage population with relapse of symptoms post product discontinuation were evaluated. Thirty infants aged 3 to 16 weeks with no significant clinical illness were enrolled in the study with their caregivers. Daily inconsolable crying time and flatulence were significantly reduced ( P < .05) within a week of intervention and a sustained effect was observed after discontinuation of the product. The findings of the present study indicate that this product effectively reduced abdominal distension and pain, resulting in a significant decrease in the daily crying of the infants. Trial registration: The study was registered with the Clinical Trials Registry India (CTRI) ( http://ctri.nic.in/Clinicaltrials/login.php ) bearing Reg. No: CTRI/2021/03/031762, Date: March 8, 2021.
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“Fennel oil is widely recognized for its relieving effects on infantile colic and digestive problems [82], but it could also be effective for the treatment of IBS symptoms, frequently in combination with medicinal plant ingredients [105].”
From Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies (2025) · cites this paper as [82]
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Indrio, F., Di Mauro, A., Riezzo, G., Civardi, E., Intini, C., Corvaglia, L., Ballardini, E., Bisceglia, M., Cinquetti, M., Brazzoduro, E., et al. (2014) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2013.4367 · Cited by 228
Ginger in gastrointestinal disorders: A systematic review of clinical trials
Nikkhah Bodagh, M., Maleki, I., & Hekmatdoost, A. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.807 · Cited by 221
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Cited by
Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies
Abalo, R., Gallego-Barceló, P., & Gabbia, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199345 · Cited by 5
Metadata
- Authors
- Evans, C., & Lorentz, W. P.
- Affiliations
- New Beginnings Pediatrics, Phillipsburg, NJ, USA
- Day and Night Pediatrics, Aventura, FL, USA
- ORCID
- Evans, Charles
- Venue
- Global Pediatric Health
- Publisher
- SAGE Publications
- Published
- 2022-01
- Volume
- 9
- ISSN
- 2333-794X
- Cited by
- 3
- References
- 2
- Language
- en
- Funders
- CalmCo., Sarasota, Florida, USA
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.