Identification of Compounds for Butyrylcholinesterase Inhibition

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Chemical Composition, Biological Activities and In Silico Analysis of Essential Oils of Three Endemic Prangos Species from Turkey

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Djeblia, L., Boutaghane, N., Bendamene, S., Kenza, B., Voutquenne‐Nazabadioko, L., Boulebd, H., May, A., Kumar, S., Kumar, K. M., Yılmaz, M. A., et al. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.202503381 · Cited by 2 · see citing works

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Cachatra, V., Martins, A., Oliveira, M. C., Oliveira, M. C., Gano, L., Paulo, A., López, Ó., Fernández‐Bolaños, J. G., Contino, M., Colabufo, N. A., et al. (2024) · Organic & Biomolecular Chemistry · doi:10.1039/d4ob01657b · Cited by 2 · see citing works

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Nunes, B. B. D. S., Mendonça, J. D. S., de Matos, L. P., Guimarães, A. T. B., Soares, W. R., Rodrigues, A. S. D. L., Govindarajan, M., Gomes, A. R., da Luz, T. M., & Malafaia, G. (2025) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-35840-z · Cited by 2 · see citing works

First in class pyrrolo[2,3‐d]pyrimidine derivatives fused to fluorobenzylpiperidines as dual ligands of acetylcholinesterase and histamine H3 receptor

Añazco, T., Werner, T., Torres, M. J., Hornos‐Carneiro, M. F., Fernández, J., Živković, A., Salas, C. O., Castro‐Álvarez, A., Gutiérrez, M., Stark, H., et al. (2025) · Archiv der Pharmazie · doi:10.1002/ardp.202400387 · Cited by 2 · see citing works

In Silico Analysis of 9H-(Fluorenyl) Methyl Lysine Carbamate Derivatives as Butyrylcholinesterase Inhibitors

Parepalli, M. C. S., & Galla, R. (2025) · Oriental Journal Of Chemistry · doi:10.13005/ojc/400621 · Cited by 1 · see citing works

Novel Purine‐Based Natural Products as Inhibitors of Cholinesterases and Monoamine Oxidases Presenting Potential Multitarget Therapeutics Tackling Alzheimer's Disease

Shaaban, A. E., Ali, A. R., Ayyad, S.-E. N., & Badria, F. A.-E. (2025) · Archiv der Pharmazie · doi:10.1002/ardp.70035 · Cited by 1 · see citing works

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Kordinová, H., Mik, V., Hemelíková, N., González, G., Štěpánková, Š., Górová, V., Bazgier, V., & Kvasnica, M. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118217 · Cited by 1 · see citing works

Theranostic advances in Alzheimer's disease: structure-guided design of near-infrared fluorescent probes targeting amyloid-β and cholinergic dysfunction

Mandloi, U., Giri, N., Kumar, S., & Modi, G. P. (2026) · RSC Medicinal Chemistry · doi:10.1039/d5md00713e · Cited by 1 · see citing works

Synthesis and Pharmacological Evaluation of Novel 1,5-Disubstituted-3-amino-1,2,4-triazoles Designed as Multitarget Directed Ligands for Alzheimer’s Disease Targets

Franco, D. P., Caruso, L., Grillo, D. C. N., Nadur, N. F., de Azevedo, L. L., Pereira, T. M., da Silva, M. C., Lacerda, R. B., Pinheiro, P. D. S. M., Riger, C. J., et al. (2026) · ACS Omega · doi:10.1021/acsomega.5c09002 · Cited by 1 · see citing works

3-Phenethyl-2-phenylquinazolin-4(3H)-one isolated from marine-derived Acremonium sp. CNQ-049 as a dual- functional inhibitor of monoamine oxidases-B and butyrylcholinesterase

Oh, J., Hillman, P. F., Nam, S., & Kim, H. (2023) · Journal of Applied Biological Chemistry · doi:10.3839/jabc.2023.024 · Cited by 1 · see citing works

Synthesis, Characterization, and Biological Evaluation of N-Methyl Derivatives of Norbelladine

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Design, Synthesis and Biological Evaluation of New Thiosemicarbazone-Acridine Derivatives as Multi-Target-Directed Ligand (Mtdl) for Alzheimer's DiseasePreprint

Sousa, G. L. S., Nadur, N. F., Ferreira, L. A., Honório, T. D. S., Simon, A., Cabral, L. M., Santos, M. L. M., Andrade, B., de Lima, E. V., Clarke, J. R., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4889012 · Cited by 1 · see citing works

The in vitro and in silico Anticholinesterase Ac-tivities of Brittle Star (Ophiocoma erinaceus) crude venoms from the Persian Gulf-Bushehr

Dehghani, H., Rashedinia, M., Mohebbi, G. H., Vazirizadeh, A., Maryamabadi, A., & Barmak, A. R. (2022) · Iranian South Medical Journal · doi:10.52547/ismj.25.4.297

Cholinesterase inhibition

Szafran, B. N., Casillas, G. A., & Alman, B. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824315-2.00826-5

Indole Alkaloids from Ochreinauclea Maingayi (Rubiaceae) as Butyrylcholinesterase Inhibitors and Their Paralysis Effect in Transgenic Caenorhabditis ElegansPreprint

Osman, N., Awang, K., Hazni, H., Khaw, K. Y., Mak, W. Q., Tiamas, S. G., Maulana, S., Zubair, M., Pudjiastuti, P., Liew, S. Y., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4767405

Freshwater Pollution by Sars-Cov-2 Lysate Protein Induces Multiple Impacts on C57bl/6j Female MicePreprint

Nunes, B. B. D. S., Mendonça, J. D. S., de Matos, L. P., Guimarães, A. T. B., Matos, S. G. D. S., de Souza, S. S., Rodrigues, A. S. D. L., Islam, A. R. M. T., Govindarajan, M., Mujawar, M., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4789640

Ferrocene-containing cholinesterase inhibitors

Genčić, M. S., Zivanovic, J., Denic, J., Nikolić, D. N., & Radulović, N. S. (2024) · Facta universitatis - series Physics Chemistry and Technology · doi:10.2298/fupct2401037g

Characterizing DPPM inhibition of butyrylcholinesterase: integrated enzymatic kinetics and Raman spectroscopy with chemometric analysis

Barney, A., Newland, A. M., Olayeri, A., Halámek, J., & Halámková, L. (2025) · The Analyst · doi:10.1039/d5an01018g

Campanula cymbalaria var. papillosa: Phytochemical profile, antioxidant activities, enzyme inhibitory effects, antibacterial activity, cytotoxicity, and molecular docking analysis

Yıldız, M., Terzi, H., Aslanlı, R., Zengin, G., Yıldız, S. H., Karaosmanoğlu, C., Uba, A. İ., Bozkurt, N. B., & Serteser, A. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.108210

Grapeseed Extract and Orlistat Association Prevent Ischemia/Reperfusion-Induced Oxidative Stress, Lipid Disturbance, and Cholinergic Transmission Alteration in Rat Brain

Ghrir, S., Alaya, A. B., Jallouli, S., Limam, F., Aouani, E., & Charradi, K. (2025) · Pharmaceutical Chemistry Journal · doi:10.1007/s11094-026-03478-5

Clitoria ternatea as a potential candidate in treating Alzheimer’s disease

Chin, J. Y., Sucedaram, Y., Hassan, Z., & Kumaran, K. R. (2026) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2026.100602

Mechanistic Insights into Bergapten by Modulation of Filamin A and GSK3β in STZ Induced Alzheimer’s Disease: An Integrated In Silico, In Vitro and In Vivo Study

Riaz, M., Qadir, H., Noman, M., Ahmed, S., Shah, F. A., Malik, M. U., Bashir, K., Farooq, U., & Irshad, N. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04744-4

Integrative structural and kinetic analysis of the molecular basis for reduced carbamate inhibition in atypical butyrylcholinesterase

Matošević, A., Maraković, N., Barić, D., Igert, A., Brazzolotto, X., Kovarik, Z., & Bosak, A. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.112134

Benzylisoquinoline Alkaloids from Nelumbinis Plumula as Potential Butyrylcholinesterase Inhibitors: Isolation, Characterization and Bioactivity Evaluation

Wei, W., Wang, D., Yang, J., Yuan, J., Xu, L., & 冯素香 (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110451

Synthesis, Biological Evaluation, and In Silico Studies of Naphtalene‐Hydrazide Derivatives as Dual‐Action Agents for Alzheimer's Disease: Targeting BChE and Oxidative Stress

Konyar, D., Hayati, O. K. U. R., Muhammed, M. T., Kaplan, A., Boğa, M., & Kılıç-Kurt, Z. (2026) · ChemistrySelect · doi:10.1002/slct.74571

Determination of the Content of Isoquinoline Alkaloids in Selected Plant Extracts and Study of Their Cholinesterase-Inhibiting Activity and Cytotoxicity Against Human Melanoma Cells Using In Vitro and In Silico Methods

Tuzimski, T., Petruczynik, A., Sugajski, M., Plech, T., Kaproń-Plech, B., Wróblewski, K., & Buszewski, B. (2026) · Molecules · doi:10.3390/molecules31193544

BindingDB Entry 50017449: Selective butyrylcholinesterase inhibition by isatin dimers and 3-indolyl-3-hydroxy-2-oxindole dimers.

BindingDB (2023) · UC San Diego · doi:10.7270/q2w381dj

BindingDB Entry 50023018: Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies.

BindingDB (2026) · UC San Diego · doi:10.7270/q2w66rnn

Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations

Zhou, Y., Lü, X., Yang, H., Chen, Y., Wang, F., Li, J., Tang, Z., Cheng, X.-F., Yang, Y., Xu, L., et al. (2019) · Molecules · doi:10.3390/molecules24234217 · Cited by 27 · see citing works

Discovery of potent and selective butyrylcholinesterase inhibitors through the use of pharmacophore-based screening

Williams, A. H., Zhou, S., & Zhan, C. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.126754 · Cited by 30 · see citing works

Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation

Pidaný, F., Křoustková, J., Mamun, A. A., Suchánková, D., Brazzolotto, X., Nachon, F., Chantegreil, F., Doležal, R., Pulkrabkova, L., Múčková, Ľ., et al. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115301 · Cited by 21 · see citing works

Discovery and mechanistic exploration of natural butyrylcholinesterase inhibitors via integrated virtual screening and multidisciplinary approaches

Liu, Y., Liu, Y., Yu, D., Yang, C., Xu, H., wang, N., Du, J., Li, L., Chen, G., Liu, Z., et al. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.152221 · Cited by 1 · see citing works

Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-Aβ Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation

Jiang, C., Ge, Y.-X., Cheng, Z., Wang, Y., Tao, H., Zhu, K., & Zhang, H. (2019) · Molecules · doi:10.3390/molecules24142568 · Cited by 29 · see citing works