Cited by 317Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeuroscience and Neuropharmacology Research

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Projections from vasopressin, oxytocin, and neurophysin neurons to neural targets in the rat and human

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Sofroniew, M V·1980·Journal of Histochemistry & Cytochemistry

DOI 10.1177/28.5.7381192

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Abstract

Projections from vasopressin, oxytocin, and neurophysin neurons to neural targets were examined using the immunoperoxidase method. In the rat, neural target areas were found in portions of the limbic system, diencephalon, mesencephalon, brain stem, and spinal cord. In the human, only target areas in the brain stem and spinal cord were investigated. The projections to these targets derive from hypothalamic magnocellular vasopressin or oxytocin neurons, as well as from parvocellular vasopressin neurons of the suprachiasmatic nucleus. In neural target areas, axo somatic, as well as axodendritic, contacts are made. The findings suggest that these projections interact with other neurons, rather than release hormone into the bloodstream.

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Gumusoglu, S. B., Blaine, B., Bertolli, A. X., Weber, M. A., Kamal, M., Hazzard, H., Schickling, B., Lauffer, M., Zhang, Y., Taylor, R., et al. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.05.301 · Cited by 1
Experimental Usage of Oxytocin to Combat Deficits in Social Cognition in Schizophrenia
Taş, C., Brown, E. C., Gonzalez, C., & Brüne, M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405172-0.00018-1 · Cited by 1
“…evidence suggests that oxytocin acts as a neuromodulator that primarily targets subcortical structures, which in turn may affect the high cortical areas that are responsible for social decision-making, empathy, theory of mind, and metacognition (MeyerLindenberg et al., 2011; Sofroniew, 1980).”
Background
The Use of Genetic Modification Techniques in the Fluorescent Visualization of Oxytocin Neurons
Katoh, A., Ueta, Y., & Suzuki, H. (2013) · Journal of UOEH · doi:10.7888/juoeh.35.165 · Cited by 1
The Hypothalamus, the Preoptic Area, and Hypothalamohypophysial Systems
ten Donkelaar, H. J., & Hori, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-41878-6_13 · Cited by 3
Use of perfluorated carboxylic acids in the separation of metabolites of vasopressin prior to radioimmunoassay
Höglund, U. (1988) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)83142-4 · Cited by 1
Effects of vasopressin on the somatic membrane of spinal ganglia neurons
Molokanova, E., & Tamarova, Z. A. (1988) · Neurophysiology · doi:10.1007/bf02150263 · Cited by 1
Facilitatory effects of monoamine synthesis inhibitors on lysine-vasopressin induced changes in the exploratory behaviour pattern of male rats
Höglund, A. U., & Meyerson, B. J. (1984) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(84)80065-9 · Cited by 1
IMPORTANCE OF ENDOGENOUS VASOPRESSIN IN THE HYPERTENSIVE AND BRADYCARDIC RESPONSE TO CENTRAL α1‐ADRENERGIC STIMULATION
Hiwatari, M., & Johnston, C. I. (1985) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1985.tb02635.x · Cited by 1
“(NTS) and the dorsal motor nucleus of the vagus (DVN) (Buijs et al. 1978; Saper et al. 1976; Sofroniew 1980).”
Background
Specificity of Agonistic and Antagonistic Analogues of Vasopressin
Sawyer, W. H., & Manning, M. (1984) · Springer eBooks · doi:10.1007/978-1-4612-5284-9_40 · Cited by 1
Epidural and intrathecal analgesia and neurosurgical techniques in the palliative setting
Phan, P., Are, M., Hassenbusch, S. J., et al. (2009) · CRC Press eBooks · doi:10.1201/b13272-58 · Cited by 1
Unilateral hypothalamic lesion results in compensatory sprouting of contralateral magnocellular neurosecretory axons in the rat neural lobe
Watt, J. A. (1989) · Montana State University ScholarWorks (Montana State University)
Distribution of oxytocin in the spinal cord and its presence in the peripheral nervous system
Jójárt, J. (2012) · doi:10.14232/phd.1478
Spinal Regulation of Sympathetic Nerve Activity and Arterial Pressure Under Conditions of Increased Plasma Osmolality
Rupp, V., & Britta, J. (2012) · University of Minnesota Digital Conservancy (University of Minnesota)
Modulação autônoma da resposta taquicárdica do exercício pela ocitocina endógena no complexo solitário vagal em ratos sedentários e treinados, normotensos e hipertensos.
Taniguchi, K. T. H. (2008) · doi:10.11606/t.42.2008.tde-15092008-115546
Effects of vasopressin and oxytocin on evoked dorsal horn cell activity in an isolated segment of spinal cord
Tamarova, Z. A. (1986) · Neurophysiology · doi:10.1007/bf01052181

Authors: Sofroniew, M. V.
Corresponding author: Sofroniew, M V
ORCID: Sofroniew, M V
Venue: Journal of Histochemistry & Cytochemistry
Publisher: SAGE Publications
Published: 1980-05
Volume: 28
Issue: 5
Pages: 475-478
ISSN: 0022-1554 (ISSN-L)
1551-5044
DOI: 10.1177/28.5.7381192
OpenAlex: W1991485877
Cited by: 317
References: 0
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 11 · 2017: 7 · 2016: 9 · 2015: 12 · 2014: 4 · 2013: 7 · 2012: 7
FWCI: 37.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Histochemistry & Cytochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: vasopressin neurons, oxytocin neurons, hypothalamic magnocellular neurons, suprachiasmatic nucleus, parvocellular neurons, neuronal projections, limbic system, diencephalon, midbrain, brainstem, spinal cord, axosomatic synapses, axodendritic synapses, neuropeptide release, rats, human
MeSH terms: Animals, Axons, Brain Chemistry, Dendrites, Humans, Hypothalamus, Neurons, Neurophysins, Oxytocin, Paraventricular Hypothalamic Nucleus, Vasopressins, Rats

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Projections from vasopressin, oxytocin, and neurophysin neurons to neural targets in the rat and human

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