The DOI matches its Crossref record.
High concentrations of a novel peptide, neuropeptide Y, in the innervation of mouse and rat heart.
Abstract
A newly discovered bioactive peptide, neuropeptide Y (NPY), has been found in the innervation of the mouse and rat heart by immunocytochemistry, NPY-immuno-reactive nerves were very dense around the nodal tissues. They also surrounded the coronary arteries and arterioles and were found in close association with the cardiac muscle. The distribution of NPY-containing nerves paralleled that of noradrenergic fibers, demonstrated by the use of antibodies to the catecholamine-converting enzymes tyrosine hydroxylase and dopamine beta-hydroxylase. Furthermore, NPY was seen to be present in a proportion of intrinsic neurons mostly found in the atria and in close proximity to the nodal tissue. The concentrations of extractable NPY-immunoreactive material (about 150 pmol/g in whole mouse heart) by far surpasses those of the other peptides so far reported in the cardiac tissue. High performance liquid chromatography demonstrated the NPY immunoreactivity to elute in a single sharp peak, in an identical position to brain NPY.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Calcitonin gene-related peptide in cardiovascular tissues of the rat
Mulderry, P. K., Ghatei, M. A., Rodrigo, J., Allen, J. M., Rosenfeld, M. G., Polak, J. M., & Bloom, S. R. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90156-3 · Cited by 334
Self-citationNeuropeptide Y: Direct and indirect action on insulin secretion in the rat
Moltz, J. H., & McDonald, J. K. (1985) · Peptides · doi:10.1016/0196-9781(85)90443-7 · Cited by 213
Increases in plasma neuropeptide Y concentrations during sympathetic activation in man
Morris, M. J., Russell, A. E., Kapoor, V., Cain, M. D., Elliott, J. M., West, M. J., Wing, L. M. H., & Chalmers, J. P. (1986) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(86)90089-5 · Cited by 159
Metadata
- Authors
- Gu, J., Polak, J. M., Allen, J. M., Huang, W. M., Sheppard, M. N., Tatemoto, K., & Bloom, S. R.
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 1984-05
- Volume
- 32
- Issue
- 5
- Pages
- 467-472
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W2100209054
- Cited by
- 163
- References
- 0
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: High concentrations of a novel peptide, neuropeptide Y, in the innervation of mouse and rat heart. https://app.cochat.ai/papers/10.1177/32.5.6546942
- The paper
- Gu, J., Polak, J. M., Allen, J. M., Huang, W. M., Sheppard, M. N., Tatemoto, K., & Bloom, S. R. (1984). High concentrations of a novel peptide, neuropeptide Y, in the innervation of mouse and rat heart. Journal of Histochemistry & Cytochemistry. https://doi.org/10.1177/32.5.6546942
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
