Cited by 91Malaria Research and ControlHemoglobinopathies and Related DisordersErythrocyte Function and Pathophysiology

Malaria: a haematological disease

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Akinosoglou, Karolina S., Solomou, Elena E., Gogos, Charalambos A.·2012·Hematology

Abstract

Plasmodium falciparum malaria remains a major cause of mortality throughout the tropical world. Haematological abnormalities are considered a hallmark of malaria, bearing an impact on final outcome and representing indices of prognostic and follow-up value. These include severe anaemia, coagulation disturbances, leukocyte numerical or functional changes and spleen involvement. Anaemia involves red blood cell lysis due to parasite invasion, as well as mechanisms of intravascular haemolysis and decreased erythropoiesis. Exchange or blood transfusion is mainly recommended in the management of these patients. Haemorrhagic complications in severe malaria are relatively rare despite prominent thrombocytopenia and dysfunction in the coagulation pathway. Numerical, as well as functional changes in the white blood cell are less dramatic than other blood cell series, but still, remain a significant index of disease progression and ultimate prognosis. Finally, the role of the spleen in severe malaria is multifactorial. Care and vigilance should be taken against splenic rupture which is fatal and can occur despite appropriate antimalarial prophylaxis and treatment.

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Authors
Akinosoglou, K. S., Solomou, E. E., & Gogos, C. A.
Affiliations
General University Hospital of Patras (GR)
Corresponding author
Akinosoglou, Karolina S.
Venue
Hematology
Published
2012-03
Volume
17
Issue
2
Pages
106-114
ISSN
  • 1024-5332 (ISSN-L)
  • 1607-8454
OpenAlex
W2077580107
Cited by
91
References
152
Citations by year
2026: 5 · 2025: 4 · 2024: 10 · 2023: 9 · 2022: 10 · 2021: 8 · 2020: 13 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 6 · 2013: 4 · 2012: 1
FWCI
4.01
Type
journal article
Language
en
Open access
Locations
  • Hematology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
  • Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
Keywords
falciparum malaria, severe malaria, hematological abnormalities, anemia, coagulopathy, thrombocytopenia, leukocyte dysfunction, splenic involvement, splenic rupture, intravascular hemolysis, blood transfusion, prognosis
MeSH terms
Anemia, Antimalarials, Blood Coagulation, Blood Transfusion, Erythropoiesis, Hemolysis, Humans, Leukocytes, Plasmodium falciparum, Splenomegaly, Thrombocytopenia, Malaria, Falciparum

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