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Cited by 30Parasitic Diseases Research and TreatmentParasites and Host InteractionsResearch on Leishmaniasis Studies

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Mansonella perstans: safety and efficacy of ivermectin alone, albendazole alone and the two drugs in combination

Asio, S. M., Simonsen, P. E., Onapa, A. W.·2009·Annals of Tropical Medicine & Parasitology
DOI 10.1179/136485909x384929
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Abstract

The safety and efficacy of a single dose of ivermectin alone (150-200 microg/kg bodyweight), albendazole alone (400 mg) or the combination of these two drugs was assessed, in Uganda, in three groups of individuals infected with Mansonella perstans (with 15, 13 and 15 subjects in each group, respectively). No side-effects were observed or reported during the first 7 days post-treatment and every subject remained microfilaraemic during the 12 months of follow-up. In the subjects given ivermectin alone or albendazole alone, the microfilarial intensities consistently remained close to their pre-treatment levels. In the subjects given both drugs, however, the microfilarial intensities decreased slightly after treatment and at 1 and 3 months post-treatment (but not at 6, 9 or 12 months) they were significantly lower than in the two other groups combined. The three single-dose drug regimens investigated were thus well tolerated but had disappointingly low efficacies in the treatment of M. perstans microfilaraemias.

Overview

Integrity signals

Registry

Crossref · 10.1179/136485909x384929

Cites

21 of 21 references verified0 citation errors · 0 not checkable

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Verification

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Citations

Cites

Research works printed but not linked: 3

  1. Simonsen, P. E. (2003). Filariases. In Manson's Tropical Diseases, 21st Edn, eds Cook, G. & Zumla, A. pp. 1487-1526. London: Saunders.
  2. Southgate B. A, 1973, Southeast Asian Journal of Tropical Medicine and Public Health, 4, 172
  3. Van den Enden E., 1992, Annales de la Société Belge de Médecine Tropicale, 72, 215

Cited by

See all 30

Metadata

Authors
Asio, S. M., Simonsen, P. E., & Onapa, A. W.
Affiliations
  • Kyambogo University (UG)
  • University of Copenhagen (DK)
  • Ministry of Health (UG)
Venue
Annals of Tropical Medicine & Parasitology
Publisher
Informa UK Limited
Published
2009-01
Volume
103
Issue
1
Pages
31-37
ISSN
  • 0003-4983 (ISSN-L)
  • 1364-8594
DOI
10.1179/136485909x384929
OpenAlex
W2004772056
Cited by
30
References
21
Citations by year
2026: 1 · 2023: 5 · 2022: 2 · 2021: 4 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
1.83
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Tropical Medicine and Parasitology (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
Keywords
Mansonella perstans, ivermectin, albendazole, combination therapy, microfilaremia, antiparasitic drug efficacy, drug safety, single-dose therapy, onchocerciasis
MeSH terms
Adolescent, Adult, Aged, Animals, Antiparasitic Agents, Child, Drug Combinations, Female, Humans, Ivermectin, Male, Mansonella, Mansonelliasis, Middle Aged, Uganda, Albendazole, Treatment Outcome, Young Adult

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.