The DOI matches its Crossref record, with a small difference in title or year; 24 of the 24 references it cites were found in a registry or an index.
Cognitive enhancing effect of the fermented Gumiganghwal-tang on scopolamine-induced memory impairment in mice
Abstract
Gumiganghwal-tang (GT) is a traditional herbal medicine that is widely used for its anti-inflammatory, analgesic, and antipyretic actions. Fermented GT has been reported to inhibit acetylcholinesterase (AChE) activity and to exert a neuroprotective effect. In this study, we investigated the effect of fermented GT against scopolamine-induced memory impairment in mice using the Morris water maze and passive avoidance tests. The results of the Morris water maze test indicated that fermented GT significantly decreased escape latency, as compared with that observed in the scopolamine-treated group. In the prove test, fermented GT attenuated the decreased time spent in the target quadrant observed after scopolamine treatment. The results of the passive avoidance test indicated that the treatment with fermented GT increased latency time when compared with the scopolamine-treated group. Moreover, fermented GT inhibited AChE activity in the hippocampi of the treated mice. These results suggest that fermented GT reduced scopolamine-induced amnesia in mice through AChE inhibition. Therefore, we hypothesize that fermented GT may be a useful therapeutic agent for the prevention or treatment of neurodegenerative diseases.
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“Nine-Herb Decoction, containing various plant extracts, and Prunella vulgaris aqueous extract have also exhibited protective effects against SCO-induced memory impairments by inhibiting AChE activity [62,63].”
From Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review (2025) · cites this paper as [62]
Citations
Cites
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A Review of Fermented Foods with Beneficial Effects on Brain and Cognitive Function
Kim, B., Hong, V. M., Yang, J., Hyun, H., Im, J. J., Hwang, J., Yoon, S. J., & Kim, J. E. (2016) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2016.21.4.297 · Cited by 136
“Fermented Bozhougyiqi-tang (78), Gumiganghwal-tang (79,80), and Hwangryunhaedok-tang (81) showed more potent protective activities against glutamate-stimulated cell death in HT22 cells than the unfermented prescription.”
BackgroundYang, M., Xuan, Z., Wang, Q., Yan, S., Zhou, D., Naman, C. B., Zhang, J., He, S., Yan, X., & Cui, W. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2021.1926140 · Cited by 46
ALNasser, M. N., Alboraiy, G. M., Alsowig, E. M., & Alqattan, F. M. (2025) · Brain Sciences · doi:10.3390/brainsci15020215 · Cited by 35
“Finally, Nine-Herb Decoction, containing various plant extracts, and Prunella vulgaris aqueous extract have also exhibited protective effects against SCO-induced memory impairments by inhibiting AChE activity [62,63].”
Ko, Y., Kwon, S., Lee, S., & Jang, C. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01172-7 · Cited by 31
Xie, M., Zhang, G., Yin, W., Hei, X.-X., & Liu, T. (2017) · Journal of Integrative Neuroscience · doi:10.3233/jin-170059 · Cited by 16
“time taken to enter the dark compartment [12].”
Background
Metadata
- Authors
- Weon, J. B., Lee, J., Eom, M. R., Jung, Y. S., & Ma, C. J.
- Affiliations
- Kangwon National University (KR)
- Corresponding author
- Ma, Choong Je
- Venue
- Nutritional Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2014-09-12
- Volume
- 19
- Issue
- 3
- Pages
- 125-130
- ISSN
- 1028-415X (ISSN-L)
- 1476-8305
- OpenAlex
- W2041580338
- Cited by
- 12
- References
- 24
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutritional Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korea Institute of Oriental Medicine
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- fermented herbal medicine, scopolamine-induced amnesia, memory impairment, acetylcholinesterase inhibition, cognitive enhancement, hippocampus, neurodegenerative diseases, traditional Korean medicine, Morris water maze, passive avoidance
- MeSH terms
- Donepezil, Acetylcholinesterase, Animals, Avoidance Learning, Behavior, Animal, Cholinesterase Inhibitors, Disease Models, Animal, Fermentation, Hippocampus, Indans, Male, Memory Disorders, Mice, Inbred ICR, Nerve Tissue Proteins, Neurons, Piperidines, Plant Extracts, Scopolamine, Cholinergic Antagonists, Nootropic Agents, Muscarinic Antagonists, Maze Learning, Dietary Supplements, Republic of Korea, GPI-Linked Proteins
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- CoChat. (2026). Citation check: Cognitive enhancing effect of the fermented Gumiganghwal-tang on scopolamine-induced memory impairment in mice. https://app.cochat.ai/papers/10.1179/1476830514y.0000000152
- The paper
- Weon, J. B., Lee, J., Eom, M. R., Jung, Y. S., & Ma, C. J. (2016). Cognitive enhancing effect of the fermented Gumiganghwal-tang on scopolamine-induced memory impairment in mice. Nutritional Neuroscience. https://doi.org/10.1179/1476830514y.0000000152
